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How the world got lost on
the road to an anti-aging pill
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February 27, 2020: by Bill Sardi
A predicament of old age is that vitamin C blood levels which once were maintained in youth cannot be easily maintained in the senior years of life. Some of this inability to maintain healthy vitamin C levels emanates from the loss of recycling of vitamin C in red blood cells.
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February 23, 2020: by Bill Sardi
Take a gander at the chart below. Data shows when intake of all alcoholic beverages is combined (wine, beer, spirits), only wine at modest intake levels (3-5 drinks/week to 1-2 drinks a day) markedly lowers the risk for death compared to other alcoholic beverages (purple).
When broken down by type of alcoholic beverage, data shows only modest wine consumption results in a striking decline in mortality
(-27%) compared to beer (increased risk for death: +37%-153% and alcohol spirits (increased risk +9-73%). [Alcohol spirits are defined as 20+% beverage alcohol content: whiskey, vodka, rum, tequila, sake, brandy.]
At high intake of ANY alcoholic beverage including wine, mortality risk increased. But at modest intake levels only wine (-27% relative risk) reduced mortality rates compared to modest intake of beer (-2%) and alcohol spirits (-3%).
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February 17, 2020: by Bill Sardi
There are vast differences in biological aging in Americans due to dietary and environmental “epigenetic” factors that switch genes on or off. Of the estimated 25,000 genes in every cell in the human body, these genes vary widely in their protein-making (epigenetics).
Researchers now report <https://www.dailymail.co.uk/news/article-8010985/DNA-analysis-shows-60-year-old-person-genetic-age-100.html> they found a 66-year old had the biological age of 114 while a 59-year old was biologically 23. Differences in smoking rates, obesity and stress were identified as drivers of aging.
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February 15, 2020: by Bill Sardi
The reviewers analyzed 88 published human studies involving a class of molecules called polyphenols like those used in Longevinex. Molecules like resveratrol, quercetin, fisetin, IP6 rice bran, and report these molecules exert profound control over blood sugar, particularly among diabetics.
Blood sugar was only modestly reduced (-3.32 milligrams/deciliter of blood) in healthy adults (as it should be) but had a more demonstrative effect among diabetics (-5.86 mg/dL) and diabetics on anti-diabetic medication (-10.17 mg/dL).
The report was issued by European researchers in the European Journal of Nutrition. It can no longer be said that polyphenols like resveratrol are unproven. ####
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February 6, 2020: by Bill Sardi
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January 14, 2020: by Bill Sardi
Heart Researchers Are Confounded by a long-term (12.3 year) study where red wine drinkers who exhibited higher circulating cholesterol numbers and more severe calcification of coronary arteries, both known risk factors for mortality, paradoxically had a much lower risk for a major heart attack or cardiac death. (Has the so-called French Paradox been uncovered –the reason why the French who consume fattier foods and drink alcohol, have far lower cardiac death rates than North Americans?)
In recent decades cardiologists have used cholesterol and calcification of coronary arteries as markers of risk for cardiac death. Historically, when it was reported as many patients with high total cholesterol die of a heart attack as those with low cholesterol, cardiologists pointed to elevated LDL (low density lipoproteins) as the chief culprit. Though there is scientific question as to whether LDL cholesterol is really linked to death from any cause.
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January 9, 2020: by Bill Sardi
Hitting futurist news wires today is the unprecedented report (journal Cell Reports) that claims modest de-activation of two gene pathways increases the lifespan of microscopic-sized roundworms by an unprecedented 400-500%. Taking into account roundworms have a genetic makeup similar to humans — 20,470 protein-making genes compared to ~25,000 in humans — genes that are arranged in a similar (homologous) fashion (position, structure, function) as humans, the application to human longevity is obvious. Now to wait four or five hundred years to find out if this is true.
Given that biologists don’t have four or five centuries to conduct a live study in humans, short-lived animals like roundworms are used in laboratory experiments. This report will likely create a stir in scientific circles as well as public disbelief. Under controlled laboratory conditions, the lifespan of roundworms was extended from ~20 to ~100 days! (400-500 years in human terms)
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January 6, 2020: by Bill Sardi
Though it is said the human body renews itself every ten years, that is not true for every tissue and organ in the body. It may never dawn on most people that while humans have a self-renewing/regenerating body, most cells in the heart, eyes and brain never renew themselves and must last for a lifetime. Once damaged or deadened, cells in these critical organs may never regain full function because of a slow rate of cell regeneration.
The cell turnover (renewal) rate varies throughout the body. If cells in the brain and heart replaced themselves as rapidly as skin cells do (a new layer of skin about every 4-6 weeks) our memories would be lost, our vision would be cloudy and our heart muscle cells would be weakened and couldn’t adequately pump blood. Cells in brain, eye and heart are designed to be replace themselves slowly, if ever at all. The brain, eye and heart cells we were born with must last a lifetime.
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January 1, 2020: by Bill Sardi
It has often been said there is magic in wine. Biologists confirmed that in recent times with the discovery resveratrol, a miracle molecule in wine, which has been called the “elixir of eternal youth.” Is resveratrol wine’s revealed secret? Only in part.
It is said that resveratrol is theoretically a molecular mimic of a calorie restricted or fasting diet, a practice known to double the lifespan and health span of animals in experimental studies. But a recent human study failed to show that resveratrol fully mirrored the beneficial effects of food deprivation. Calorie restriction (30-50% fewer calories) was found to be superior to resveratrol in another earlier study. Resveratrol does activate a key survival gene, Sirtuin1, that is also activated by limited calorie diets. But resveratrol doesn’t fully do what a limited calorie diet accomplishes.
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December 26, 2019: by Bill Sardi
Fisetin, naturally abundant in strawberries, is a newly recognized entry in a field of anti-aging molecules that are widely studied but underutilized in modern medicine. A recent study shows consumers with the highest dietary consumption of strawberries have a much lower risk for brain aging. Researchers show that strawberry supplementation reduces risk factors for heart disease, including blood pressure, inflammation, and total cholesterol.
Once single-gene targeted synthetic drugs failed to become the “holy grail” for youth-promising drugs, natural molecules like resveratrol, quercetin, catechin, have been difficult to improve upon. These small molecules are advantageous because they can pass through cell walls to influence genetic machinery. They pass through blood/brain and blood/ocular barriers. And they target many, many genes, more when combined to achieve synergistic effects.
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