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How the world got lost on
the road to an anti-aging pill
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November 7, 2019: by Bill Sardi
Resveratrol, the much dismissed but underused red wine molecule, purported to produce near-miracle cures, yet written off as being non-bioavailable and largely shunned in medical practice, exhibits an unparalleled range of biological activities, such as:
… that also induces a transient gas (nitric oxide) that in turn dilates (widens) constricted blood vessels.
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October 15, 2019: by Bill Sardi
It’s a bit gnawing to watch the vision of America’s senior adults fade as they age due to an incurable and insidiously progressive disease called macular degeneration.
Since macular degeneration is regarded as irreversible, what is needed is a way to maintain eye health rather than treat existing disease, given that it won’t go away once diagnosed.
And it is that objective, to maintain eye health rather than detect, prevent or treat disease that is the exclusive purpose of dietary supplements, a.k.a. nutraceuticals.
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September 16, 2019: by Bill Sardi
A few months ago I penned a report asking Why Isn’t Resveratrol Being Used After Every Heart Attack?” The report revealed stent-happy cardiologists only presume they are saving lives with stents AFTER damage to the heart has already been done.
Resveratrol has been documented to reduce the size of a heart attack (area of scarring, or fibrosis, as cardiologists call it). One lone non-invasive cardiologist even reported a live case where the protective effect could be observed by doctors who for reasons of patient age and fragility could not safely advance a wire into a blocked coronary artery (called balloon angioplasty) and noticed the 90-year old patient who had been taking a resveratrol pill (Longevinex®) experienced no damage to his heart.
For ethical reasons, such an experiment in the animal lab can’t be duplicated in humans.
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September 8, 2019: by Bill Sardi
There is a new leader in anti-aging science and his schooling is not in genetics or biology but rather statistics and mathematics.
Step aside David Sinclair PhD, Harvard Medical School geneticist who in 2004 announced the discovery of the Sirtuin1 gene, which is activated by a lifespan prolong calorie-restricted diet and by resveratrol, a molecule found in red wine, a discovery that explained the French Paradox – why the wine-drinking French have higher cholesterol numbers but far fewer heart attacks than North Americans.
Take a backseat in the lecture hall Leonard Guarente, PhD at MIT who in 2014 introduced a designer niacin-like molecule that also activates the Sirtuin1 survival gene and serves as an anti-aging pill.
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September 5, 2019: by Bill Sardi
It was May of 2017. I was on the telephone explaining to a Washington Post medical reporter that a major scientific breakthrough was about to be announced at an international scientific meeting of eye researchers (ARVO) in nearby Baltimore. The Washington Post had been purchased by Jeff Bezos, Amazon.com chief executive four years earlier in 2013.
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August 16, 2019: by Bill Sardi
In this “aging is optional” era, with many middle-age longevity seekers eyeing the prospect of living 120 healthy years, a newly published study says the possibility of living that long is remote. So, shall longevity seekers throw away their anti-aging pills and save their money?
In a world of “fake news” it is not surprising to learn that the reported number of super-centenarians (110+ years of age) around the world, concentrated in so-called “blue zones” around the globe (Okinawa, Japan; Ikaria in Greece; the isle of Sardinia near Italy), are largely comprised of oldsters with no birth certificates to prove they have lived eleven decades and/or whose families have not reported their deaths in order to maintain delivery of government retirement checks.
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August 5, 2019: by Bill Sardi
Longevity seekers have heard all this before, but we hear more today:
“Anti-Ageing drugs are coming” – New Scientist April 2019; Medical Xpress Sept. 2018
“Longevity and anti-aging research: prime time for an impact on the globe” – Harvard Gazette March 2019
“Healthy To 100?” — San Diego Union Tribune July 2019
You may be alive when the first anti-aging pill is granted approval by health authorities. Or hve one or two already materialized but just dismissed by those who seek to control the anti-aging marketplace? Or will public health authorities ever let an anti-aging pill gain traction?
Anti-aging investigator Josh Mitteldorf says “it may soon be possible to measure changes in the rate of human aging over periods as short as a year or two” instead of the impractical challenge of a lifetime study in humans to produce conclusive evidence.
Don’t hold your breath for the first human trial of an purported anti-aging pill (anti-diabetic drug metformin/Glucophage) is about to begin, and will take 5-7 years to complete. But metformin only increased lifespan in lab animals by 4-6%.
Is the public being set up for disappointment that will dash or delay the approval of more promising anti-aging agents? And given that metformin may induce vitamin deficiencies and other side effects such as chronic diarrhea, I wouldn’t be surprised if the study were sponsored by the makers of Depend® adult diapers.
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July 30, 2019: by Bill Sardi
Researchers now say the red wine molecule resveratrol “opens a new door for depression and anxiety” treatment because it has been found, for the first time, to shut off an enzyme in the brain thought to excite these adverse mental states. Resveratrol is non-prescription and non-addictive and according to data accumulated by the Poison Control Centers of America over the past decade, very safe. A just-published laboratory study in the journal Neuropharmacology confirms resveratrol convincingly inhibits anxiety/depression-like behavior in mice. Animals could handle stress better.
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July 23, 2019: by Bill Sardi
Health authorities now warn 29 million American adults they should cease taking aspirin tablets for heart health, given there are no benefits and only serious side effects such as bleeding gastric ulcers and brain hemorrhages, not to mention anemia, heartburn, vitamin C depletion and death. Resveratrol, the red wine molecule, is suggested as a replacement as it:
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July 18, 2019: by Bill Sardi
Oh, that’s just a headline to gain your attention. However, it is based upon recently published science (Frontiers in Physiology July 18, 2019) showing the red wine molecule RESVERATROL “mitigated” partial (0.38 g) gravity conditions as found on the planet Mars in laboratory animals.
Resveratrol was shown to preserve muscle function and mitigate muscle atrophy (shrinkage) in partial gravity conditions among laboratory mice. Scientifically resveratrol is already known as a physical exercise mimetic.
While there are zero space travelers to Mars at the present time, this research has application to humans living into their eighth and ninth decades who experience bone and muscle loss, a condition called sarcopenia.
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