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How the world got lost on
the road to an anti-aging pill
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January 14, 2020: by Bill Sardi
Heart Researchers Are Confounded by a long-term (12.3 year) study where red wine drinkers who exhibited higher circulating cholesterol numbers and more severe calcification of coronary arteries, both known risk factors for mortality, paradoxically had a much lower risk for a major heart attack or cardiac death. (Has the so-called French Paradox been uncovered –the reason why the French who consume fattier foods and drink alcohol, have far lower cardiac death rates than North Americans?)
In recent decades cardiologists have used cholesterol and calcification of coronary arteries as markers of risk for cardiac death. Historically, when it was reported as many patients with high total cholesterol die of a heart attack as those with low cholesterol, cardiologists pointed to elevated LDL (low density lipoproteins) as the chief culprit. Though there is scientific question as to whether LDL cholesterol is really linked to death from any cause.
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January 9, 2020: by Bill Sardi
Hitting futurist news wires today is the unprecedented report (journal Cell Reports) that claims modest de-activation of two gene pathways increases the lifespan of microscopic-sized roundworms by an unprecedented 400-500%. Taking into account roundworms have a genetic makeup similar to humans — 20,470 protein-making genes compared to ~25,000 in humans — genes that are arranged in a similar (homologous) fashion (position, structure, function) as humans, the application to human longevity is obvious. Now to wait four or five hundred years to find out if this is true.
Given that biologists don’t have four or five centuries to conduct a live study in humans, short-lived animals like roundworms are used in laboratory experiments. This report will likely create a stir in scientific circles as well as public disbelief. Under controlled laboratory conditions, the lifespan of roundworms was extended from ~20 to ~100 days! (400-500 years in human terms)
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January 6, 2020: by Bill Sardi
Though it is said the human body renews itself every ten years, that is not true for every tissue and organ in the body. It may never dawn on most people that while humans have a self-renewing/regenerating body, most cells in the heart, eyes and brain never renew themselves and must last for a lifetime. Once damaged or deadened, cells in these critical organs may never regain full function because of a slow rate of cell regeneration.
The cell turnover (renewal) rate varies throughout the body. If cells in the brain and heart replaced themselves as rapidly as skin cells do (a new layer of skin about every 4-6 weeks) our memories would be lost, our vision would be cloudy and our heart muscle cells would be weakened and couldn’t adequately pump blood. Cells in brain, eye and heart are designed to be replace themselves slowly, if ever at all. The brain, eye and heart cells we were born with must last a lifetime.
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January 1, 2020: by Bill Sardi
It has often been said there is magic in wine. Biologists confirmed that in recent times with the discovery resveratrol, a miracle molecule in wine, which has been called the “elixir of eternal youth.” Is resveratrol wine’s revealed secret? Only in part.
It is said that resveratrol is theoretically a molecular mimic of a calorie restricted or fasting diet, a practice known to double the lifespan and health span of animals in experimental studies. But a recent human study failed to show that resveratrol fully mirrored the beneficial effects of food deprivation. Calorie restriction (30-50% fewer calories) was found to be superior to resveratrol in another earlier study. Resveratrol does activate a key survival gene, Sirtuin1, that is also activated by limited calorie diets. But resveratrol doesn’t fully do what a limited calorie diet accomplishes.
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December 26, 2019: by Bill Sardi
Fisetin, naturally abundant in strawberries, is a newly recognized entry in a field of anti-aging molecules that are widely studied but underutilized in modern medicine. A recent study shows consumers with the highest dietary consumption of strawberries have a much lower risk for brain aging. Researchers show that strawberry supplementation reduces risk factors for heart disease, including blood pressure, inflammation, and total cholesterol.
Once single-gene targeted synthetic drugs failed to become the “holy grail” for youth-promising drugs, natural molecules like resveratrol, quercetin, catechin, have been difficult to improve upon. These small molecules are advantageous because they can pass through cell walls to influence genetic machinery. They pass through blood/brain and blood/ocular barriers. And they target many, many genes, more when combined to achieve synergistic effects.
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December 23, 2019: by Bill Sardi
Scientific evidence
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December 18, 2019: by Bill Sardi
Would you know a miracle if you saw one?
At the time of the writing of this report, of the 12,383 published science journal reports involving red wine molecule resveratrol (rez-vair-a-trol) listed at the National Library of Medicine, only one report used the word “miraculous” to describe its health properties.
What unequivocal evidence can be provided to classify this red wine molecule as a miracle?
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December 12, 2019: by Bill Sardi
There is no practical way that the toxicity of all of the environmental pollutants that people are exposed to in this modern world can be assessed as a whole. Exposure limits to toxins are established for individual toxins and don’t account for all of the complexities of occupational and non-occupational hazards.
As a troubling report in TOXICOLOGY REPORTS states: “There is no reason today to believe that the single exposure limits on potentially toxic agents that have been established by regulatory agencies are fully protective against serious adverse health effects in all real life exposure scenarios.”
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December 7, 2019: by Bill Sardi
Modern medicine is at it again, attempting to develop an expensive synthetic molecule that will reap billions of dollars of sales when there is a more economical natural molecule that may even work in a superior fashion to a heralded new drug.
Here’s the new option now that researchers believe a recent breakthrough can avert age-related mental decline: (1) wait ten years for completed trials of a synthetic drug that abolishes memory loss which commonly occurs with advancing age; or (2) take resveratrol pills that work by a similar if not stronger mechanism than the aforementioned drug.
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November 21, 2019: by Bill Sardi
With clot-busting aspirin tablets having fallen from grace, heart researchers are now having second thoughts about stents that prop open narrowed or blocked coronary arteries.
For inexplicable reasons, the FDA approves medical devices like stents before they are fully vetted.
With the coronary artery stent business predicted to reach the $8 billion/year mark by 2025, Wall Street maybe ought not to count future profits too fast as a newly published study may have just foiled the marketing plans for these wire props that are placed within coronary arteries where blockages, narrowing or clots occur.
A landmark study conducted by New York University researchers found coronary artery stents may reduce angina chest pain but does not do so any better than blood thinners nor do stents reduce the risk for heart attack or premature death.
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