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May 20, 2020: by Bill Sardi
MIT researchers made news headlines over a discovery that could help people not only live longer but retain their memory and other mental capacities throughout life.
There are three ways to control genes: 1) by activation or inactivation of proteins, called gene expression or silencing; 2) alteration of microRNA; or 3) by tightening or loosening DNA strands around spools called histone bodies. Histone bodies are comprised of lysine and arginine. Think of a DNA strand like a cord wrapped around a tennis ball (histone body). When strands of DNA are bound loosely around histone bodies, the DNA sequences can be “read” and activated. When DNA strands are tightened around histone bodies, the genes are shut off.
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May 9, 2020: by Bill Sardi
Resveratrol elevates NAD + (Nicotinamide adenine dinucleotide), a molecule that is considered to have anti-aging properties via its elevation of cell energy. IT has been said that “all roads to longevity lead to NAD+.” NAD+ that is naturally derived from niacin. Resveratrol elevated NAD+ by a more powerful mechanism than niacin (vitamin B3). Niacin precursors nicotinamide riboside (Niagen) and Nicotinamide Mononucleotide (NMN) are widely touted as dietary supplements as precursors of NAD+. Sixty years of science points to a derivative of niacin, nicotinamide, that stimulates NAD+. But the question remains: does plain niacin or niacinamide elevate NAD+ in a far more economical way? We now have a definitive answer to that question.
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March 22, 2020: by Bill Sardi
A newly published report indicates beta cyclodextrin, a solubilizing and anti-cholesterol agent in Longevinex®, inhibits attachment of coronaviruses to infect cells. According to a report published in the March 2020 issue of Acta Biomedica, cyclodextrin also inhibits the molecular doorway (ACE2) for coronaviruses to enter cells. Cyclodextrin essentially competes with viral targets for entry into healthy cells. Cyclodextrins are sugar-like molecules that serve as stabilizers and as a molecular delivery system.
Longevinex® Provides Five Molecules That Either Inhibit Coronavirus Infection Or Support Overall Immunity
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February 27, 2020: by Bill Sardi
A predicament of old age is that vitamin C blood levels which once were maintained in youth cannot be easily maintained in the senior years of life. Some of this inability to maintain healthy vitamin C levels emanates from the loss of recycling of vitamin C in red blood cells.
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February 23, 2020: by Bill Sardi
Take a gander at the chart below. Data shows when intake of all alcoholic beverages is combined (wine, beer, spirits), only wine at modest intake levels (3-5 drinks/week to 1-2 drinks a day) markedly lowers the risk for death compared to other alcoholic beverages (purple).
When broken down by type of alcoholic beverage, data shows only modest wine consumption results in a striking decline in mortality
(-27%) compared to beer (increased risk for death: +37%-153% and alcohol spirits (increased risk +9-73%). [Alcohol spirits are defined as 20+% beverage alcohol content: whiskey, vodka, rum, tequila, sake, brandy.]
At high intake of ANY alcoholic beverage including wine, mortality risk increased. But at modest intake levels only wine (-27% relative risk) reduced mortality rates compared to modest intake of beer (-2%) and alcohol spirits (-3%).
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February 17, 2020: by Bill Sardi
There are vast differences in biological aging in Americans due to dietary and environmental “epigenetic” factors that switch genes on or off. Of the estimated 25,000 genes in every cell in the human body, these genes vary widely in their protein-making (epigenetics).
Researchers now report <https://www.dailymail.co.uk/news/article-8010985/DNA-analysis-shows-60-year-old-person-genetic-age-100.html> they found a 66-year old had the biological age of 114 while a 59-year old was biologically 23. Differences in smoking rates, obesity and stress were identified as drivers of aging.
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February 15, 2020: by Bill Sardi
The reviewers analyzed 88 published human studies involving a class of molecules called polyphenols like those used in Longevinex. Molecules like resveratrol, quercetin, fisetin, IP6 rice bran, and report these molecules exert profound control over blood sugar, particularly among diabetics.
Blood sugar was only modestly reduced (-3.32 milligrams/deciliter of blood) in healthy adults (as it should be) but had a more demonstrative effect among diabetics (-5.86 mg/dL) and diabetics on anti-diabetic medication (-10.17 mg/dL).
The report was issued by European researchers in the European Journal of Nutrition. It can no longer be said that polyphenols like resveratrol are unproven. ####
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February 6, 2020: by Bill Sardi
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January 14, 2020: by Bill Sardi
Heart Researchers Are Confounded by a long-term (12.3 year) study where red wine drinkers who exhibited higher circulating cholesterol numbers and more severe calcification of coronary arteries, both known risk factors for mortality, paradoxically had a much lower risk for a major heart attack or cardiac death. (Has the so-called French Paradox been uncovered –the reason why the French who consume fattier foods and drink alcohol, have far lower cardiac death rates than North Americans?)
In recent decades cardiologists have used cholesterol and calcification of coronary arteries as markers of risk for cardiac death. Historically, when it was reported as many patients with high total cholesterol die of a heart attack as those with low cholesterol, cardiologists pointed to elevated LDL (low density lipoproteins) as the chief culprit. Though there is scientific question as to whether LDL cholesterol is really linked to death from any cause.
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January 9, 2020: by Bill Sardi
Hitting futurist news wires today is the unprecedented report (journal Cell Reports) that claims modest de-activation of two gene pathways increases the lifespan of microscopic-sized roundworms by an unprecedented 400-500%. Taking into account roundworms have a genetic makeup similar to humans — 20,470 protein-making genes compared to ~25,000 in humans — genes that are arranged in a similar (homologous) fashion (position, structure, function) as humans, the application to human longevity is obvious. Now to wait four or five hundred years to find out if this is true.
Given that biologists don’t have four or five centuries to conduct a live study in humans, short-lived animals like roundworms are used in laboratory experiments. This report will likely create a stir in scientific circles as well as public disbelief. Under controlled laboratory conditions, the lifespan of roundworms was extended from ~20 to ~100 days! (400-500 years in human terms)
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