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  • Marching Towards Superlongevity

    January 5, 2022: by Bill Sardi

    At Some Point Modern Medicine Is Just Going To Let You Die

    Choosing to live super-long doesn’t sound plausible.  Many people believe longevity is governed by their forefathers who passed on good genes.  But every human has the same set of genes.

    For the most part, genes aren’t fixed.  Only ~2% of disease is inherited.  Genes respond and adapt to the environment, temperature, radiation, food supply, by making proteins, what is called gene expression; or by not making proteins, which is called gene silencing.  So how do we influence our genes so we can live indefinitely long?  The answer to that question is presented below.

    Certainly no one who smokes tobacco, uses illicit drugs, eats volumes of processed sugarized food with abandon, should expect to live much longer than their parents.  While those members of the Calorie Restriction Society DO attempt to live longer and healthier than their ancestors, given studies reveal limited (-40%) calorie diets double lifespan and healthspan in laboratory animals.

    However, this idea is not linear.  If we add 500 calories to our diet every day we will shorten our lives by how much?  That isn’t what calorie restriction is about.  It is about sending a signal to the body that something is stressing the body (near starvation), and therefore the human body responds by activating internal antioxidants (glutathione, catalase, superoxide dismutase -SOD) via a genetic switch called Nrf2.  That stressor needs to be mild, not acute.

    A little bit of a toxin is called a hormesis effect. Other pungent hormetic agents are allicin from garlic or ellagic acid from cloves, qualify as hormesis molecules, but only if given in modest doses.  It needs to be a little bit of a toxin that triggers the body to activate Nrf2.  Too much resveratrol, the effect is negated. Those 1000 milligram resveratrol pills sold as “more for your money” have no reason for being.

    Also, via a governor enzyme called AMPK which is activated by a limited calorie diet, people will either burn or store calories and produce more energy in the form of ATP in the mitochondria of their cells.  A limited calorie diet puts the body in a fat burning rather than sugar burning mode, like we were when we were young.  The anti-diabetic drug metformin activates AMPK.  Resveratrol does it 50-200 times better.

    We can also use small molecules that mimic a calorie restricted diet and “have our cake and eat it too.”  Such molecules are polyphenols like resveratrol (grapes), quercetin (apple peel), fisetin (strawberries), catechin (tea), cinnamaldehyde (cinnamon) and others.

    These small molecules work synergistically rather than just additively when combined. Again, the combined dosage of these molecules needs to be modest to activate Nrf2.  Then should you experience a heart attack or a stroke, damage will be limited, if at all.

    But we are headed to nowhere says a biology professor

    With all of this said, a noted biology professor now says, as a human society, we are not going to break the record for the longest individual lifespan (122 years) because we treat the very old as if they are going to die anyway and are too old and frail to survive a surgical operation, or whatever treatment modern medicine offers.

    Mikhail V Blagosklonny, PhD, claims, without a scientific breakthrough, the maximum lifespan could be prolonged considerably if oldsters were treated like younger adults.  Doctors are just letting people die.  If 110 years old, what’s the use of doing a heart bypass operation?  That is the thinking, says Blagosklonny.  As evidence, he cites a study that shows 62.7% of patients older than 80 years were not offered cancer care.  “Humans can be sacrificed unintentionally by avoidance of aggressive treatment,” he says.

    Focused on youthfulness, not healthy longevity

    Many senior adults are focused on the cosmetic aspects of aging, grey hair, facial wrinkles, which do not predict mortality, he goes on to say. But humans are governed by the mirror.  To the individual, looking old is just as bad a curse as aging itself.

    What drives aging?

    But what drives aging?  That hasn’t been clearly addressed in biology.  Yes, certain longevity genes need to be activated, like the Sirtuin1 survival gene.  Now if we just pump Sirtuin1 gene protein in people, will they live longer?  Answer: no.  Because more is not better.  Remember, hormesis.

    That would be like moving the clock hands backward and saying we are living longer.  Actually, if we sped up time by getting the earth to spin faster, we would just be counting more years in the same amount of time and fooling ourselves.  So instead of living to 100 we might live 120 shortened years.  Net sum game = zero.

    Mineral overload is what drives aging

    The driver of aging is minerals.  This has been proven time and again.  When we are growing are invincible, immune to most diseases, with stamina beyond comprehension.  What causes us to slow down, think slower, have trouble recalling names and faces, grow feeble and frail?  It is the accumulation of minerals after full childhood growth is achieved, around age 18.

    Up to that point we have needed all the iron we can get to make new red blood cells.  About 200 million red blood cells die off every day and need replacement.  We need 24 milligrams of daily iron to make hemoglobin, the iron-carrying part of red blood cells.  Fortunately, the body recycles some iron.  We need calcium to make new bone.  We need copper to make connective tissue.  Then growth ceases and the demand for minerals plateaus.

    Full-grown men begin to accumulate iron.  Full-grown women, being the baby carriers, must be protected from disease, and dump iron once a month in menstrual blood losses, and donate calcium to build a new skeleton in their offspring.  Fertile childr-bearing women don’t overload with iron or calcium.

    By age 40 males have accumulated 4 times as much calcium and twice as much iron in their bodies as equally-aged males, and they experience double the rate of diabetes, heart disease and cancer.  If a female undergoes an early hysterectomy and therefore no longer controls her iron, she will incur the same rate of disease as males.  (Source: The Iron Time Bomb, B Sardi)

    Therefore, metal chelators (key-lay-tors) or binders would control the rate of aging and would be appropriate for full-grown males and post-menopausal females.

    Trimming calcium-rich dairy and iron-rich meat from the diet would be beneficial after full childhood growth in males and baby-making in females.  Blood-letting as an exercise in iron removal can also be practiced given that 90% of iron in the body is housed in red blood cells.

    Essentially, via removal of excessive minerals would reverse aging, not just slow it.  It is with this understanding that we realize via mineral control we can achieve an indefinitely long and healthy lifespan.

    It is no wonder that the superiority of the strawberry molecule fisetin to inhibit cell senescence effectively results in less frail older adults.  Fisetin chelates excess iron.  Live long with these lessons learned here today my friends.

    As Dr. Blagosklonny warns, at some point modern medicine is just going to let you die.

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