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How the world got lost on
the road to an anti-aging pill
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February 1, 2017: by Bill Sardi
The newly published study is compelling — especially given the fact one medication is not likely to result in control of blood pressure. Just 50 milligrams of resveratrol used as a companion with lisinopril (ACE inhibitor) meaningfully increases the effectiveness of anti-hypertensive therapy. [Experimental & Therapeutic Medicine 2017]
The medical control of blood pressure is low, between 30-50% with an additional 20-30% resistant to treatment. The frequency with which the target control blood pressure level can be achieved with use of a single drug is also low. It usually takes two drugs to meaningfully control blood pressure with fewer than half of the patients achieving control. [American Journal Hypertension 2001; Centers for Disease Control]
January 30, 2017: by Bill Sardi
Although a thrombus (blood clot) in a coronary artery that supplies the heart with oxygenated blood is the most frequent cause of death among men, “its immediate cause has always been wrapped up in mystery.” — Pathologist Paris Constantinides, Journal American Medical Assn.,1964.
In 1990 an article published in The New York Times stated that cardiologists “had a nagging sense that a big piece of the puzzle of why people have heart attacks was missing…. although doctors conventionally attributed heart attacks to severe narrowing of the heart’s arteries from fatty deposits, they found in studying the coronaries of heart attack victims that the vessels were often relatively clean. And some cardiac patients had none of the known risks, like smoking, diabetes, high blood pressure and high cholesterol.”
January 24, 2017: by Bill Sardi
Another regime change – Americans have endured a few of them. But has any new administration in Washington DC made even a dent in the relentless increase in the cost of medical care?
January 18, 2017: by Bill Sardi
With recognition human studies of aging and longevity would take many decades to produce conclusive evidence, researchers who study aging must resort to studying animals with shorter lifespans in an attempt to discover strategies for humans to live longer and healthier.
One such strategy is calorie restriction that doubles healthspan and lifespan of lower life forms and small animals. For larger-bodied longer-living animal studies, the primate monkeys, researchers had to wait more than two decades when animals began to die off to determine differences in survivability.
January 9, 2017: by Bill Sardi
Why are researchers at an obscure university in India lecturing western doctors over the misdirection of modern medicine in the prevention and treatment of Alzheimer’s disease?
Investigators at little-known Bharathidasan University in Tiruchirappalli, Tamilnadu State, India, who labor under the motto “we will create a brave new world,” (no, not Johns Hopkins Medical School or Harvard Medical School or the Mayo Clinic in the USA) boldly cite how the red wine molecule resveratrol is superior to statin drugs in addressing the buildup of beta amyloid (cholesterol-like) plaque in the aging brain that is associated with Alzheimer’s disease.
January 7, 2017: by Bill Sardi
There have been many efforts to produce an advanced resveratrol pill that stabilizes this wonder molecule, enhances its oral absorption, maximizes its immediate bioavailability (get as much unbound resveratrol past the liver’s detoxification system), enhances its biological activity, delivers it in modest doses to produce a hormetic effect (hormesis = provision of a biological stressor in a mild dose to activate the body’s internal antioxidant system) and deliver it safely without potential toxicity when administered intended or unintended mega-doses. [Current Drug Delivery Nov 9, 2016; Journal Controlled Release March 10, 2012]
January 3, 2017: by Bill Sardi
The problem is quite apparent – women over age 65 proportionally account for 63% of dementia sufferers worldwide and health authorities anticipate this difference will become more pronounced as more women live into their tenth decade of life. This problem is believed to emanate from a reduced ability of arteries in the brain to dilate (widen) under conditions of mental demand or emotional or physical stress.
The age-related decline in estrogen production from the ovaries is identified as a chief reason for these aging changes in mental function in women.
January 1, 2017: by Bill Sardi
Ignoring prior science that shows the red wine molecule resveratrol blocks oxidative stress and convincingly prevents cell senescence, a researcher at Erasmus University Medical Center in the Netherlands says elimination of senescent cells from an aging body is now plausible.
As cells age they lose their ability to divide and replicate. This so-called cellular senescence is an obvious hindrance to the growth of cancerous cells but removal of senescent cells from animals resulted in animals hair regrowth, improved organ function and faster-paced running. [Science Daily Dec 29, 2016] So reversal of cell senescence (not just slowing senescence) appears to be a bona fide anti-aging strategy.
December 27, 2016: by Bill Sardi
December 16, 2016: by Bill Sardi
The first images of laboratory mice reprogrammed to reverse aging are presented above. [Cell Dec 15, 2016] Laboratory mice genetically altered to age prematurely show signs of age reversal upon epigenetic reprogramming. The mouse on the right (-Dox) exhibits a curved spine characteristic of a premature aging syndrome called progeria in humans. The reprogrammed mouse on the left (+Dox) exhibits a more youthful thicker coat and absence of the abnormal spine curvature. Internal organs were also more youthful in reprogrammed mice. Animals were genetically altered to produce a premature aging syndrome akin to progeria, which results in shortened lifespan (~13 years in humans) with premature baldness, cataracts and skin wrinkling in youth. While progeria is caused by a mutation in a single gene (LMNA, pronounced lamin-A) researchers were able to reverse aging changes in these animals by alteration of protein-making (i.e. epigenetics) in just four genes (known as Yamanaka factors). Mice and humans house a similar library of genes (~25,000) in the nucleus of their cells. The age-reversal effects were accomplished by returning cells back to their original embryonic state in order to remove certain epigenetic marks that occur in aging without altering the abnormal sequence of DNA (gene mutations) responsible for premature aging itself. This suggests biological fate can be changed.