Comprehensive Library Of Resveratrol News

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  • Oral Resveratrol Supplement Raises Blood Levels Of Sirtuin1 Survival Gene Protein As Well As A Calorie-Restricted Diet

    July 25, 2018: by Bill Sardi


    Well, it took 14 years for the research community to conduct a simple human study to determine if resveratrol raises Sirtuin1 gene protein blood levels as well as a calorie restricted diet.  The study was conducted among healthy or slightly overweight subjects.  Since blood measures of cholesterol, insulin and blood sugar were already within the healthy range in these subjects, neither a limited calorie diet nor resveratrol had any significant effects upon these measures, nor upon heart rate, weight, waist circumference or blood pressure.
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  • News Headline: Methylated Resveratrol (Pterostilbene) Trumps Plain Resveratrol. But Is All As It Seems?

    July 11, 2018: by Bill Sardi


    A news report is making resveratrol pill users wonder whether they are using the best form of this molecule for their health.  Scientific debate continues over whether a form of resveratrol that is advertised to be more bioavailable (pterostilbene) is superior to plain resveratrol.

    As background information, resveratrol is a molecule that human body perceives as a toxin and seeks to detoxify it as it passes through the liver.   Resveratrol is an antioxidant when given in modest doses (100-350 mg) but promotes oxidation when given in mega-doses (2800 mg).

    For example, a human equivalent dose of 2800 mg was shown to increase the size of a heart attack (area of damaged heart muscle) whereas a modest dose decreases the area of damage.  In fact, 2800 mg resveratrol actually “kills” a pumping rodent heart.   However, when resveratrol is complexed with quercetin and rice bran IP6 (Longevinex®) there is no cardiac toxicity whatsoever (see chart below), making Longevinex® the safest resveratrol pill available should mega-doses be mistakenly consumed.

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  • Longevity, Imagined Overpopulation, Immigration, How To Avoid The Soylent Green Processing Truck & How To Edit Your Genes & Get Back In The Saddle Again With Resveratrol Pills

    June 29, 2018: by Bill Sardi


    As I write on this 4th of July 2018 so many questions flood my mind regarding human longevity.  Where is humanity headed?  One unquestionable direction is, despite the vast majority of humans on the planet live in poverty and suffer from malnutrition, is that people are reported to be living far longer in developed countries.  How much longer?  Well, maybe just ten years.

    Life expectancy is not an accurate measure of longevity because it is skewed downward by infant mortality.  What is instructive is global life expectancy at age 60, which is tabulated at Global Watch Index.

    Data tabulated for 2015 shows in a number of advanced countries, people at age 60 are likely to live another 25 years or so (tops is Japan at 26 years; US 23 years) whereas in undeveloped lands, people reaching age 60 are likely to live another 15 years.  So the net lifespan gain accomplished by access and delivery of modern medicines, antibiotics, etc. is about 10 years when population groups are compared.

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  • When “Finally Put To The Test” NutritionFacts.Org Says Resveratrol Pills Fail. We know better.

    May 24, 2018: by Bill Sardi


    If a newly published report is correct, that resveratrol (rez-vair-a-trol) dietary supplements are based upon on thread-thin if not altogether bogus science, I ought to be confessing I’m a charlatan and snake oil salesman and resign from my self-appointed position as defender of res-pills and editor at ResveratrolNews.com

    The latest knife that has been thrown at resveratrol comes from a doctor-run website that claims it is an authoritative non-commercial source of information on topics like resveratrol.   The NutritionFacts.org website accepts no advertising and has no hidden sponsors.  There is no product line of dietary supplements that are being sold covertly at “SnakeOilWondersupplements.com.”  We are all pleased to hear that.

    Anyone who has commercial interest in resveratrol pills, like myself, is biased I guess.  Yes, after living 73 years without any evident disease or need for medication, without a hint of a cloudy cataract or cholesterol (drusen) deposits at the back of my eyes that are apparent in 91% of adults my age, I guess I am biased.

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  • Resveratrol Improves All Measures Of Cardiovascular Health Even When Instituted Months After A Stroke

    May 11, 2018: by Bill Sardi


    The use of 100 milligrams of supplemental resveratrol (rez-vair-a-trol) among post-stroke patients (average age 65) improves all measures of health compared to standard medical treatment including body mass index, blood pressure, cholesterol, blood glucose and hemoglobin A1c, a measure of long-term blood sugar control.

    In some patients resveratrol was instituted months after the occurrence of a stroke but still produced a positive result.  No strokes reoccurred during the study period in any group (control group/standard medical treatment or resveratrol group).

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  • Telomerase: Research To Nowhere?

    May 2, 2018: by Bill Sardi


    It is true that laboratory mice engineered to lack telomerase, an enzyme that facilitates lengthening of end-caps (telomeres) on chromosomes (bundles of DNA), became prematurely decrepit.   But can human aging be slowed by elevation of telomerase activity?  Probably not, because the decrepit mice were not normal mice.  These animals were “grossly abnormal” and genetically engineered to age prematurely.  What has been demonstrated in the laboratory may not apply to humans.

    But research that is headed nowhere continues.  No telomere anti-aging drugs have been developed.  But researchers will do anything to get another research grant.  So yet another report that speculates telomerase is the fountain of youth was recently published and made headlines news.
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  • Moonshot Medicine: Who Can Afford It?

    April 19, 2018: by Bill Sardi


    The medical research community now talks of moonshots (big leap-forward cures), regenerative medicine, precision individualized medicine, even one-time complete treatment cures. It is all part of the 21st Century Cures Act, which spreads $4.8 billion of research funding in an attempt to accelerate the development and approval of real cures. But will this Herculean effort bankrupt insurance pools?

    The money is being directed toward expensive pharmacological cures that will further burst the Medicare Trust fund. Gobs of federal money are going towards innovations, like CRISPR gene therapy, that intends to completely remedy single-gene mutation diseases like cystic fibrosis, sickle cell, Huntington’s disease, and muscular dystrophy, all cured in a single treatment. But at what cost?

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  • First Genetically Modified Humans; But Maybe Try Resveratrol First

    : by Bill Sardi


    Modern medicine likes to pull off hoaxes, like the great cholesterol hoax that is still in play after four decades. It likes to produce expensive cures on deliver them on its own terms. Inexpensive remedies are shunned, go untested, are said to be unproven (but not disproven), and are peddled by hucksters.

    Now that you have that straightened out in your mind, you will love/loathe to hear that humans are about to be genetically edited. No, this is not an attempt to build a super-race of humans. But it is, well, a bit of an expensive scientific high-wire act that will be used to “cure” a blood disorder.

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  • Resveratrol: The Biological Rhythm Reset Button

    April 16, 2018: by Bill Sardi


    Day / Night Cycle

    The human body and all living creatures for that matter have a biological clock entranced and synchronized by day and night (light and dark) cycles, what is called the 24-hour circadian rhythm.  As humans age their inability to maintain synchronous sleep/wake cycles shortens lifespan.  It is no surprise then to learn that with advancing age those individuals who retain uninterrupted nighttime sleep cycles tend to live longer.

    Likewise, exposure of animals to artificially short or long light/dark cycles shortens their lifespan.

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  • All Roads To Longevity Linked To NAD

    April 13, 2018: by Bill Sardi


    Over a decade ago genetic researchers claimed niacin (vitamin B3), being ubiquitously found in food, serves as a “found-food signal” while resveratrol, a red wine molecule, serves to produce a “food deprivation” signal that mimics a calorie restricted diet.  We were told resveratrol activates the Sirtuin1 survival gene whereas niacin shuts it off.  However, we are now told the niacin derivative NAD boosts Sirtuin1 gene protein levels.

    Fast forward to today.  The target of life-prolonging calorie-restricted diets is NAD –nicotinamide adenine dinucleotide.   Resveratrol is now considered passé.  Niacin derivatives are posed as “beyond resveratrol” pills.   This is despite the fact resveratrol is probably a more powerful NAD booster.

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