test your knowledge
How the world got lost on
the road to an anti-aging pill
Subscribe to our newsletter to receive email notifications when new articles are posted.
February 8, 2014: by Bill Sardi
Back in July of 2013 this writer rebutted a published report in The Journal of Physiology that resveratrol reversed the beneficial effects of exercise among healthy aged males. I wasn’t the only party who objected to the false conclusions made by researchers at the University of Copenhagen.
I noted that at no time did any of the measured numbers, cholesterol, blood pressure or blood sugar, fall outside the optimal range in the group that took resveratrol, though they were marginally different from males given a placebo pill. The conclusions drawn from this study, and the widespread news headlines that followed, were are giant misdirection.
January 5, 2014: by Bill Sardi
“Old age is the harbor
of all ills.” -Bion
January 3, 2014: by Bill Sardi
Recently researchers said they were able to reverse biological aging for the first time using a derivative of vitamin B3 niacin.
A report in the journal CELL noted that the use of a derivative of vitamin B3/niacin called nicotinamide stimulates the production of nicotinamide adenine dinucleotide (NAD), a key protein in cellular metabolism (use of sugar for cellular energy) and cellular respiration (use of oxygen for cellular energy) in the mitochondria of cells.
There are a few hundred mitochondria in living cells. Mitochondria are atomic power plants that produce cell energy in the form of adenotriphosphate (ATP). By molecularly promoting more NAD/ATP in the mitochondria researchers were able to demonstrate that aging largely occurs in the mitochondria rather than the nucleus of cells and that production of NAD was able to reverse aging in muscle tissue of a laboratory mouse equivalent to making a 60-year old human 20-years old again!
December 24, 2013: by Bill Sardi
When a Harvard biologist announced biological aging had been reversed in just one week by the use of a compound that invigorates energy-producing compartments called mitochondria inside living cells, the news was spread worldwide. But the bottom line lesson from this landmark study was to wait a few years for Big Pharma to develop an expensive prescription drug to duplicate this unprecedented experiment.
And indeed, the results of the experiment were extraordinary – the muscle tissue in an aged (22-month old) laboratory mouse reverted back to a more youthful state in just one week, equivalent to turning a 60-year old human back to being 20 again! (A technical abstract of the report is published at the journal CELL.) Now if we could only erase those wrinkles!
December 20, 2013: by Bill Sardi
November 8, 2013: by Bill Sardi
In 2003 when a Harvard professor first heralded resveratrol (rezvair-ah-trol) as the key molecule in red wine that was both responsible for the French Paradox (the fact the wine-drinking French experienced a far lower rate of mortality from coronary artery disease than North Americans) and it also molecularly mimics a calorie-restricted diet, one would have bet it would be an up and coming dietary supplement or maybe even an FDA-approved drug. It had been touted as the only molecule found to block the development of all three stages of cancer (initiation, growth and spread) in 1997.
But ten years later, after researchers repeatedly (and falsely) claimed resveratrol is not biologically available, and after it was intentionally overdosed animals and even humans to produce negative studies, and a leading researcher was falsely accused of scientific fraud, sales of this promising natural molecule are in steep decline. Three years ago sales of resveratrol supplements were estimated at $30,000,000 and have now dropped below $18,000,000.
October 24, 2013: by Bill Sardi
Virologists, reporting in Nature Medicine, are searching for a way to make a universal flu vaccine that would address fast-mutating flu viruses that vaccines cannot possibly develop antibodies towards. Surface proteins on flu viruses mutate so rapidly that block flu vaccines from addressing the exact flu strain in circulation.
Researchers have discovered that volunteers who develop flu symptoms and experience only mild symptoms have more of a particular type of white blood cell – identified as CD8-T cells. (T-cells are generated from the thymus gland.) CD8-T cells target the core of the flu virus rather than the surface proteins the conventional vaccines address. A CD8-T cell activating vaccine is in the making, say researchers.
October 11, 2013: by Bill Sardi
It’s being called a “turning point in the history of Alzheimer’s disease” as scientists report they have halted the death of brain cells in laboratory mice.
Investigators say this discovery may “raise the possibility of new drugs to treat brain conditions like Parkinson’s disease as well as Alzheimer’s.”
These researchers describe their work “as the first real evidence it is possible to use a drug to stop diseased brain cells from dying.”
October 4, 2013: by Bill Sardi
After a decade of scientific doubt that resveratrol is biologically available in the human body following liver metabolism, cancer researchers in Great Britain demonstrate that not only does the red wine molecule resveratrol exert biological action but liver metabolism potentiates it.
Mistakenly believing resveratrol is not biologically available once it attaches to detoxification molecules (sulfate, glucuronate) as it passes through the liver, in 2010 mega-dose (5000 mg) resveratrol was employed in a human study of bone marrow (multiple myeloma) patients which resulted in immediate kidney failure that put a halt to the trial.
Also a human clinical trial has been launched employing mega-dose resveratrol among Alzheimer’s subjects, with dosing being established by the assumption resveratrol is not bioavailable.
September 25, 2013: by Bill Sardi
The poverty in India has led to the common practice that Hippocrates embraced: “Let food be thy medicine and medicine thy food.” Many East Indian medical researchers fondly embrace this idea as it is a customary part of the gastronomy of this still impoverished country.
Having visited there twice to attend recent scientific research symposiums, first in Chennai (the old Madras) and then Kolkata (the old Calcutta), it is clearly evident that spices added to many East Indian dishes serve as medicine. Many households there cannot afford western medicines. Aspirin, as cheap as it may seem, is not popular there. The herb holy basil serves as the aspirin of India.