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How the world got lost on
the road to an anti-aging pill
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October 5, 2014: by Bill Sardi
Researchers now recognize that autism involves modifiable genetic factors in the brain. In the proposed therapy genes are not structurally altered but their ability to make proteins (called gene expression) is modified by use of vitamins and other small molecules. It may be possible to molecularly reverse autism. [Epigenomics June 2011]
Only a small fraction of autistic children exhibit gene mutations (structural problems in the DNA ladder). Early environmental exposure to chemicals is strongly suspected as causal. Children today are surrounded by thousands of synthetic chemicals. Two hundred of them are neurotoxic in adult humans, and 1000 more in laboratory models. [Current Opinion Pediatrics April 2010]
Researchers even postulate that seemingly innocuous chemicals in perfumes need to be investigated to see if there is any association with autism since chemicals in perfumes are expected to reach the developing fetal brain. [Medical Hypotheses June 2013]
September 30, 2014: by Bill Sardi
Oh no, not another cure for cancer. It’s not another laetrile is it?
It was April Fools’ Day 2007 and an op-ed article published by The New York Times entitled “Patents Over Patients” by Ralph Moss, noted critic of the cancer industry. But there was no fooling about what Mr. Moss wrote about. He chastised the cancer industry for ignoring an off-the-shelf molecule initially produced in the 1940s called 3-bromopyruvate (3-BP) that had been found to dramatically reduce the growth of human tumors implanted in animals and has produced remarkable cures in a small number of human cases but had yet to be tested in a human trial. That was seven years ago. The initial animal lab discovery was published in 2004. That was 10 years ago.
September 24, 2014: by Bill Sardi
Set your sights on living 75 productive years and then lay down your baton, refuse any further medical interventions and await the day they are going to etch on you tombstone. That is what one of the advisors to Obamacare now suggests.
His name is Dr. Ezekiel Emanuel who says he doesn’t force his opinion on others who want to live longer than that. He just says he thinks life is definitely on a downhill slope after 75 years and there isn’t much left to accomplish except to witness your own mental and physical decline.
Dr. Emanuel’s position statement can be found at The Atlantic online. [The Atlantic Sept 17, 2014] Dr. Emanuel is 57, his parents are in their 80s.
September 23, 2014: by ResveratrolNews
European Journal Nutrition 2014 Sep 11. [Epub ahead of print]
The increased consumption of high-fructose corn syrup (HFCS) may contribute to the worldwide epidemic of fatty liver. In this study, we have investigated whether HFCS intake (20 % beverages) influences lipid synthesis and accumulation in conjunction with insulin receptor substrate-1/2 (IRS-1; IRS-2), endothelial nitric oxide synthase (eNOS), sirtuin 1 (SIRT1) and inducible NOS (iNOS) gene expressions in liver of rats. Resveratrol was tested for its potential efficacy on changes induced by HFCS.
September 17, 2014: by Bill Sardi
A disturbing study in the journal Ophthalmology, a publication of the American Academy of Ophthalmology, is likely to turn attempts to prevent and treat macular degeneration with dietary supplements upside down. The report is likely to cause dismay and confusion among patients with the disease who have been faithfully taking mineral or antioxidant formulas to delay visual decline. [Ophthalmology Sept 4, 2014]
September 12, 2014: by Bill Sardi
Hold your breath one more time before we put any new discovery into practice that could dramatically increase the human healthspan and lifespan. The latest study shows that activation of a gene that controls cell energy in key organs slows aging throughout the body and increases the lifespan of fruit flies by 30%. [UCLA Newsroom Sept 8, 2014] That is equivalent to adding another 20 healthy years to the human lifespan if this science is applicable to humans (and it is!).
The medical and biological research community is piling up libraries of breakthrough basic research but putting the brakes on applied science. Almost every research paper involving longevity ends with the demand that more research needs to be done before proceeding ahead. Why not activate the same gene in humans that was activated in fruit flies and figure out all the biological mechanisms later? You can enter the heavenly state of enduring health and longevity but not before the high priests of biology say so. The latest breakthrough in biology is an example.
September 5, 2014: by Bill Sardi
The editor of the journal Pharmacological Research is calling it the “resveratrol fiasco.” [Pharmacological Research Aug 30, 2014] Researchers in Hong Kong are calling resveratrol “a hopeless illusion.” [Pharmacological Research Aug 22, 2013]
Decrying the lack of human research studies, claiming the promised hope of resveratrol has been hiding behind “non-human research as a cover” for back-door marketing of resveratrol dietary supplements, these investigators say resveratrol, the much heralded red wine molecule that is believed to be partly responsible for the French Paradox, “may indeed turn out to be nothing more than a sleight of hand.”
September 4, 2014: by Bill Sardi
I’ve written twice at ResveratrolNews.com about the idea of taking telomere-lengthening pills in hopes of achieving biological immortality, or at least living far longer. Telomeres are caps at the end of bundles of chromosomes. Telomeres shorten with advancing age which leads to instability of the entire genome (library of genes).
My first report in 2010 presented some pros and cons but summarily concluded that telomere-lengthening pills were not ready for prime time. [ResveratrolNews.com Oct 28, 2010]
Questions about taking telomere-lengthening pills continue to be received by this journalist. Regardless of the unconvincing science, telomere modification continues to fascinate longevity seekers.
September 2, 2014: by Bill Sardi
Arsenic is ubiquitous in groundwater supplies throughout the U.S. The Environmental Protection Agency permits 10 micrograms of arsenic per liter of drinking water. [US Geological Survey] The health risks posed by small amounts of arsenic have been described. [YouTube.com] ancer from pooling of arsenic in the bladder has been reported. [Journal Epidemiology Community Health 2006] The Environmental Protection Agency habitually over-warns about even the lowest exposure to potentially toxic molecules like arsenic. Arsenic exposure needs to be reviewed in light of experimental evidence showing low-dose arsenic may activate internal antioxidant defenses in the human body (what is called hormesis). [Human Experimental Toxicology Nov 2007] However, health risks associated with accumulated lifetime exposure are unknown. In regard to arsenic antidotes, resveratrol has recently undergone testing in an animal model of arsenic poisoning and was found to reverse liver damage and elevate antioxidant defenses such as glutathione. [Biomedical Research International July 2, 2014]
August 29, 2014: by Bill Sardi
There is a clear dichotomy in the treatment of patients who battle the loss of their vision due to wet (neovascular) macular degeneration while simultaneously attempting to mend scarred muscle tissue after a heart attack.
This may be a greater problem than realized as ophthalmologists who commonly instill anti-growth factor drugs (anti vascular endothelial growth factor or anti-VEGF drugs) directly into the eye to induce abnormal blood vessels to recede may be completely unaware how many of their retinal degeneration patients have had a heart attack that requires the formation of new blood vessels to heal scarred muscle tissue.