test your knowledge
How the world got lost on
the road to an anti-aging pill
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September 7, 2015: by Bill Sardi
On the heels of submission for an FDA-approved trial of what may become the first FDA-approved anti-aging pill [ResveratrolNews June 22, 2015] comes word that scientists have developed gene chip technology that can rapidly analyze a blood sample to distinguish biological age from chronological (calendar) age in humans. [Daily Mail UK Sept 6, 2015]
The technology was not confined to lab animals but rather was proven in humans, which suggests it could become available as early as next year and have immediate application to help identify healthy organ donors and to establish life and health insurance rates. [Genome Biology Volume 16, Sept 2015]
September 2, 2015: by Bill Sardi
To: Jessica Aschemann-Witzel,
MAPP Centre—Research on Value Creation in the Food Sector,
Aarhus University, Aarhus, Denmark. firstname.lastname@example.org
From: Bill Sardi, Resveratrol Partners LLC, Las Vegas, NV (www.Longevinex.com)
After reading the report entitled “Resveratrol and health from a consumer perspective” as published in the August 2015 issue of the Annals of the New York Academy of Sciences (abstract at bottom), I offer the following comments:
August 27, 2015: by Bill Sardi
Today’s news headlines once again attribute recent declines in coronary heart disease mortality to statin drugs and modern treatments like arterial stents.
Citing a report in the European Heart Journal, The Daily Mail, a British publication, mistakenly claims Great Britain has “one of the best records in Europe” with 184 deaths per 100,000 people for coronary heart disease — a dramatic 46.9% decline over the past 10 years. [European Heart Journal Aug 25, 2015; Daily Mail UK Aug 26, 2015] Yet the chart below reveals Great Britain (United Kingdom) isn’t even in the top 10 countries with the lowest death rate for coronary artery disease.
August 16, 2015: by Bill Sardi
No, one doesn’t have to be courageous to take resveratrol supplements but researchers report, for the first time, that resveratrol may embolden those who fortify their diet with it.
Researchers have created a fearless super-intelligent mouse in the laboratory by alteration of a single gene. This was accomplished, not by alteration of the structure of a gene or repair of a gene mutation but by epigenetic inhibition of a protein (an enzyme) that is produced by this gene.
August 7, 2015: by Bill Sardi
In recent years longevity seekers have become enthralled with the idea of maintaining the end caps of their chromosomes, called telomeres) to live successfully past the age of 100. Now researchers say control of chronic low-grade inflammation is predictive of healthy aging and telomere length is not. [Ebiomedicine Aug 5, 2015]
When super-longevity is passed on to children of super-centenarians they do so via control over low-grade inflammation that results in telomere maintenance – at age 80 their telomeres are like 60-year olds. [Medicalxpress Aug 5, 2015]
Chronic low-grade inflammation is associated with risk of death, loss of mental capacity and loss of independent living.
July 24, 2015: by Bill Sardi
The answer to the above question is “we may never know.” Big Pharma’s and Modern Medicine’s mantra is that the use of herbal supplements is unproven. Yes, but will they ever put resveratrol to the test in human studies? Resveratrol has not been disproven as a GLP-1 activator in humans. It was shown to activate glucagon-like peptide-1 in an animal study. [PLoS One June 6, 2011]
The publicity machines behind the drug companies herald the “discovery” of a stop-eating hormone, glucagon-like peptide-1.
[Daily Mail UK July 23, 2015] But GLP-1 was first described in the 1980s. So GLP-1 is not new. In fact, there are already three GLP-1 drugs on the market.
July 15, 2015: by Bill Sardi
Researchers are astounded once again by resveratrol’s ability to protect living cells from damage due to heart attacks and strokes. In the most recently published experiment, a single dose of resveratrol given to laboratory mice 14 days prior to an intentionally induced stroke reduced brain damage caused by an intentionally induced stroke by 33%. Every other day dosing of resveratrol reduced area of brain damage to a similar degree (27%). In other animal studies resveratrol has also been shown to protect against stroke when administered after a stroke.
July 7, 2015: by Bill Sardi
A recent study published in the Annals of Internal Medicine notes the accumulation of calcium in arteries predicts mortality. An adult with a calcium arterial score 1000 as determined by a CT scan will face a 626% increased risk of premature death compared to an adult with a calcium arterial score of 0-10. Overall 15-year mortality rates ranged from 3% to 28% for calcium arterial scores from 0 to 1000 or greater. [Annals Internal Medicine July 7, 2015]
July 5, 2015: by Bill Sardi
This writer has already reported that the prospect of an anti-aging pill gaining official approval by the Food & Drug Administration has inched closer to reality with the submission of a proposal for a 5-7-year study involving 3000 subjects 70-80 years of age. The study would cost $50 million but funding has not yet been approved. [Nature June 17, 2015]
If the study is approved by the FDA and funded by the National Institutes of Health somewhere around the year 2020-2022 the world would hear whether Metformin, already an FDA-approved anti-diabetic drug, serves to slow or even reverse aging and the become the world’s first approved anti-aging pill. From existing published literature it can be said with a some degree of certainty the answer will be yes.
June 27, 2015: by Bill Sardi
American consumers are reticent to begin using resveratrol dietary supplements because they are unfamiliar with it. Sales of other herbal products such as garlic and curcumin from turmeric spice used for a variety of ailments, milk thistle for liver disease, Echinacea for the common cold and saw palmetto for prostate enlargement soar over resveratrol, which isn’t even in the top 100 selling herbal products.
Many consumers feel they need permission from their doctor to use resveratrol while they have no hesitation to use the above-mentioned herbs even though resveratrol has not been reported to produce serious side effects since it was widely publicized over a decade ago.
The shame is that modern medicine will not put resveratrol to the test in controlled human studies. The very scientific impetus behind resveratrol was as a red wine molecule that may be responsible for the French paradox as described by French physician Serge Renaud in the early 1990s. The French paradox is the fact the wine-drinking French eat fatty foods and have higher blood cholesterol levels but far lower mortality rates for coronary artery disease. [Novartis Foundation Symposium 1998]