test your knowledge
How the world got lost on
the road to an anti-aging pill
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November 8, 2013: by Bill Sardi
In 2003 when a Harvard professor first heralded resveratrol (rezvair-ah-trol) as the key molecule in red wine that was both responsible for the French Paradox (the fact the wine-drinking French experienced a far lower rate of mortality from coronary artery disease than North Americans) and it also molecularly mimics a calorie-restricted diet, one would have bet it would be an up and coming dietary supplement or maybe even an FDA-approved drug. It had been touted as the only molecule found to block the development of all three stages of cancer (initiation, growth and spread) in 1997.
But ten years later, after researchers repeatedly (and falsely) claimed resveratrol is not biologically available, and after it was intentionally overdosed animals and even humans to produce negative studies, and a leading researcher was falsely accused of scientific fraud, sales of this promising natural molecule are in steep decline. Three years ago sales of resveratrol supplements were estimated at $30,000,000 and have now dropped below $18,000,000.
October 24, 2013: by Bill Sardi
Virologists, reporting in Nature Medicine, are searching for a way to make a universal flu vaccine that would address fast-mutating flu viruses that vaccines cannot possibly develop antibodies towards. Surface proteins on flu viruses mutate so rapidly that block flu vaccines from addressing the exact flu strain in circulation.
Researchers have discovered that volunteers who develop flu symptoms and experience only mild symptoms have more of a particular type of white blood cell – identified as CD8-T cells. (T-cells are generated from the thymus gland.) CD8-T cells target the core of the flu virus rather than the surface proteins the conventional vaccines address. A CD8-T cell activating vaccine is in the making, say researchers.
October 11, 2013: by Bill Sardi
It’s being called a “turning point in the history of Alzheimer’s disease” as scientists report they have halted the death of brain cells in laboratory mice.
Investigators say this discovery may “raise the possibility of new drugs to treat brain conditions like Parkinson’s disease as well as Alzheimer’s.”
These researchers describe their work “as the first real evidence it is possible to use a drug to stop diseased brain cells from dying.”
October 4, 2013: by Bill Sardi
After a decade of scientific doubt that resveratrol is biologically available in the human body following liver metabolism, cancer researchers in Great Britain demonstrate that not only does the red wine molecule resveratrol exert biological action but liver metabolism potentiates it.
Mistakenly believing resveratrol is not biologically available once it attaches to detoxification molecules (sulfate, glucuronate) as it passes through the liver, in 2010 mega-dose (5000 mg) resveratrol was employed in a human study of bone marrow (multiple myeloma) patients which resulted in immediate kidney failure that put a halt to the trial.
Also a human clinical trial has been launched employing mega-dose resveratrol among Alzheimer’s subjects, with dosing being established by the assumption resveratrol is not bioavailable.
September 25, 2013: by Bill Sardi
The poverty in India has led to the common practice that Hippocrates embraced: “Let food be thy medicine and medicine thy food.” Many East Indian medical researchers fondly embrace this idea as it is a customary part of the gastronomy of this still impoverished country.
Having visited there twice to attend recent scientific research symposiums, first in Chennai (the old Madras) and then Kolkata (the old Calcutta), it is clearly evident that spices added to many East Indian dishes serve as medicine. Many households there cannot afford western medicines. Aspirin, as cheap as it may seem, is not popular there. The herb holy basil serves as the aspirin of India.
September 20, 2013: by Bill Sardi
Marketing a resveratrol-based dietary supplement has given me a front-row seat to view how modern medicine obfuscates science and throws in other roadblocks to indefinitely delay public acceptance of a truly miraculous natural molecule.
Examination of events and published studies involving the red wine molecule resveratrol (rez-vair-a-trol) over the past decade reveals nine ways modern medicine has attempted to muddy the science and delay public adoption of this natural molecule as an affordable dietary supplement.
September 19, 2013: by Bill Sardi
There is one technology challenge that is still beyond the reach of wealthy elite humans — avoidance of death.
Dare they chase the wind in an attempt to capture immortality?
That is what Google co-founder and CEO Larry Page now sets his sights on – an anti-aging pill. However, there are a lot of obstacles intentionally being thrown in the way.
Google’s objective is not new, nor is it far-fetched.
September 6, 2013: by Bill Sardi
If it is a patentable synthetic molecule that could make research institutions and pharmaceutical companies billions of dollars, it will surely be heralded. But if it is an un-patentable natural molecule that does the same thing at far less cost, it will predictably be dismissed.
That is the current state of affairs when it comes to technology that would limit damage caused by a heart attack.
Researchers at Yale University report their MIF20 small molecule reduced damage to heart muscle by ~40% in an experimental animal model. The Yale researchers report their findings here.
These Yale researchers “Suggest that augmentation of endogenous MIF signal transduction via pharmacological activation” to address “susceptibility to ischemic (heart) tissue damage.”
August 20, 2013: by Bill Sardi
While many Americans mistakenly believe they will not live as long others in their age group, Americans are more likely to live two to three decades beyond the typical date of retirement (age 65) even without the aid of predicted new advances in medical technology intended to slow the rate of aging.
About 46 percent of pre-retirees think they will not live as long as the average person their age and gender, according to the recently published Society of Actuaries’ Retirement Risk Survey that compared respondents’ estimates of personal life expectancy to those of the population as a whole.
But strikingly, according to the above report, approximately half the population will live longer than their average life expectancy.
August 7, 2013: by Bill Sardi
Friday, August 9, 2013: Bill Sardi interviews Emmy-Award Winning Journalist George Knapp On KLAV-Radio
Tune in Friday at 9:00 AM Pacific Time, via the internet (also archived for later listening), or locally in Las Vegas at 1230AM on the radio dial, for a scintillating interview with the reporter who took on Big Pharma and brought public attention to Longevinex®.
Managing a dietary supplement company as I do, I have been in a unique position to launch, for the first-time, an effort to circumnavigate the Food & Drug Administration’s onerous grip over dietary supplements.