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How the world got lost on
the road to an anti-aging pill
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December 29, 2014: by Bill Sardi
2014 was another year of great promise and inexcusable dawdling by the research community as well as intentional disparagement of what may be the most profound health and longevity molecule ever discovered — resveratrol. Strikingly, there are no human clinical trials for resveratrol for heart disease or cancer, two of its most promising applications. For now, lab rats will be the primary beneficiaries of this remarkable molecule.
One thing is for sure, the research community isn’t taking its foot off the pedal – just over one thousand published studies, commentaries and reviews about resveratrol were posted at the National Library of Medicine this year. That is out of a pool of 7000 published reports dating back to 1978. [PubMed.gov Accessed 12/18/2014]
December 26, 2014: by Bill Sardi
Well, we are getting the message loud and clear. Any anti-aging pill is going to be an expensive and controlled prescription drug rather than a widely available and economical nutraceutical whether consumers like it or not. The masses of the world won’t likely be able to afford it and doctors will extract their cut along with Big Pharma or the world will be left to wallow in the curse of aging.
While the red wine molecule resveratrol has been proposed as an anti-aging pill over the past decade, an FDA-approved drug – rapamycin (ask) Sirolimus) — just danced past it by taking its first successful baby-step as an anti-aging drug. There are no human trials that measure a marker of aging and resveratrol.
December 23, 2014: by Bill Sardi
After learning resveratrol was first discovered in 1939 and that there have been over 7000 research reports and reviews published in scientific journals dating back to 1978 involving this red wine molecule, it is difficult to fathom a major discovery involving a critically important gene target of resveratrol has just now been uncovered. But that is the news headline today. [Medical Xpress Dec 22, 2014]
Resveratrol (rez-vair-ah-trol) has been found to molecularly mimic the amino acid tyrosine and simulate protective biological mechanisms that occur during starvation say researchers at Scripps Institute. Their report is published in the December 22 early online issue of Nature. [Nature Dec 22, 2014]
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December 16, 2014: by Bill Sardi
Longevity seekers often pay too much attention to lengthening telomeres, those end caps on our chromosomes, or even activation of known longevity genes such as the sirtuin1 survival gene. The question remains: precisely what causes humans to get old and why does the rate of aging differ from individual to individual? What influences genes to accelerate or slow the rate of aging? The same library of ~20,000 genes is housed inside the billions of cells in every human body. What causes one person’s set of genes to age them faster than another individual?
December 9, 2014: by Bill Sardi
A. I think of all the various theories about why humans age, the antioxidant theory, the hormonal theory, the wear-and-tear theory, the mitochondrial theory, the telomere theory, the immune theory, (there are many more), none of them help explain why humans age at three different speeds. Whatever theory of aging that is put to the test should consider this fact.
The 3-speeds of human aging idea springs from studies that measure the rate of deposition of cellular “garbage.” The buildup of “toxic waste” is said to be responsible for the curse of aging. [Science Aging Knowledge & Environment Feb 2, 2005]
November 27, 2014: by Bill Sardi
It was heralded in 1997 as the most promising anti-cancer molecule found in nature. [Science Jan 10, 10997]
It stops cancer in all three stages of development (initiation, growth and spread), unlike any existing anti-cancer drug. [Cancer Prevention Research May 2009]
It inhibits the development of new blood vessels that feeds tumors. [International Journal Oncology Dec 2013]
November 24, 2014: by Bill Sardi
November 17, 2014: by Bill Sardi
November 14, 2014: by Bill Sardi
Reporting in the journal ALCOHOL, researchers at the University of Gothenberg incorrectly conclude that alcohol and red wine offers little benefit to healthy people seeking to keep their hearts healthy. Their study measured reduction of HDL cholesterol and presumed reduction of coronary heart disease. [Alcohol Nov. 2014] A news headline says: “Bad News For People Who Think Alcohol Is Healthy.” [Huffington Post Nov 13, 32014] But the conclusion of their study should have been that HDL cholesterol, not alcohol, has little effect on coronary heart disease.
November 9, 2014: by Bill Sardi