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How the world got lost on
the road to an anti-aging pill
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May 25, 2016: by Bill Sardi
Yes, a bona fide anti-aging pill made the front-page of the New York Times recently. And this time it wasn’t resveratrol.
Researcher Matt Kaeberlein at the University of Washington was shown in a photograph throwing a toy to one of his study subjects – his dog. And that article in the NY Times got trumped by the many, many comments from readers that revealed just how well the public warms up to the idea of an anti-aging pill (not very). In fact, a follow-up story entitled “Many Readers Say No To Idea of Life-Extending Drug, But Yes For Their Pets,” was more revealing.
May 21, 2016: by Bill Sardi
Is there a phenomenon in biology that can bring back people from the dead? Well, yes, since a person may stop breathing and their heart may stop pumping, but brain or heart muscle damage may not be experienced until later when oxygen supply is restored and toxic oxygen free radicals generated. In medicine this is called reperfusion injury.
In the interim when a subject may appear to be dead, when tissues are totally or partially deprived of oxygen (anoxia or hypoxia), pre-event activation of powerful internal antioxidants may avert heart and brain damage and the patient is revived.
May 17, 2016: by admin
Most of the people on planet earth live on less than $4 a day. Many are illiterate. In their struggle to survive, they cannot even fathom what is going on in the elitist genetic laboratories around the world where the quest to develop a genetically perfect human is now on the drawing board.
Yes, a synthetic human if you will. Geneticists have already read the human genome but now they want to re-write it. That is, synthetic genetic information, the entire library of genes called the human genome, would be implanted inside a living cell in the first step toward creating a human being without a biological father or mother.
May 9, 2016: by Bill Sardi
Researchers now turn toward resveratrol to activate a direct cancer cell-killing effect via activation of natural killer cells in a new era of immune-cell cancer therapy.
Natural killer cells are a class of white blood cells that comprise a small fraction of all the white blood cells in the blood circulation but can have profound anti-tumor effect.
Natural killer cells can target cancer cells without prior “priming” as other white blood cells are required to do. Natural killer cells can recognize and eliminate tumor and virus-infected cells, some parasites and certain types of bacteria by release of toxic substances such as interferon. [International Journal Molecular Sciences 2016]
April 26, 2016: by Bill Sardi
April 24, 2016: by Bill Sardi
It has been recognized for over a decade that red wine molecules known as polyphenols favorably alter the makeup of gut bacteria to reduce risk for colon cancer and inhibit growth of implanted tumor cells. [Mutation Research 2005] But until a recently reported study strikingly demonstrated how resveratrol inhibits accumulation of fatty plaques in the walls of arteries via its ability to alter the composition of bacteria in the intestines, this indirect mechanism has been largely overlooked. [MBio April 5, 2016]
The ability of red wine molecules to foster the growth of healthy bacteria in the intestines, namely Bifidus, is now well established. [Redox Biology 2014; Food & Function 2016; Journal Clinical Gastroenterology 2012]
April 11, 2016: by Bill Sardi
The ability of the red wine molecule resveratrol (res-vair-ah-trol) to favorably alter the family of bacteria in the human digestive tract known as the microbiome is just now beginning to be appreciated. [ResveratrolNews.com January 7, 2016] A new revelation is that resveratrol inhibits a chemical in the gut that is implicated in arterial disease (atherosclerosis). [American Society Microbiology]
Investigators used lab mice that were genetically altered to be prone to atherosclerosis (fatty plaque buildup in arteries) to make it easier to prove their point.
More than 90% of the bacteria in the human gut come from two groups – Bacteroidetes and Firmicutes. Mice fed a choline-rich diet (example: eggs) that markedly increases the bacterial concentrations of Bacteroides and decreases the concentrations of Firmicutes compared to mice given normal animal chow. Choline decreases Bacteroides — Lactobacillus acidophilus and Bifidobactium, considered to be “good bacteria.”
March 29, 2016: by Bill Sardi
According to a compilation of recently published science the red wine molecule resveratrol (res-vair-ah-trol) is poised to open an era of regenerative medicine that could profoundly add many years to the healthspan and lifespan of Americans.
Why? Because, as researchers recently pointed out, any technology that delays the age-related decline in the human immune system could result in a generation of senior Americans who live 120 healthy years or more. [Ebiomedicine 2016]
While American medicine has stumbled around for the past decade or two debating how to do this [Immunology Reviews 2005], resveratrol has now been found to counter virtually all of the genetic pathways that lead to the age-related decline in the human immune system, a fate that affects virtually all senior adults over age 60 and results in otherwise avoidable cases of pneumonia and cancer as well as chronic inflammation and autoimmune disorders.
March 12, 2016: by Bill Sardi
Resveratrol pills are posed as a molecular mimic of a limited calorie diet. Short of a ten-decades long study it may be difficult to produce conclusive evidence that resveratrol pills promote the same lifespan-healthspan doubling effect of a calorie-restricted diet in laboratory animals. Such a study would be impractical as well as exceedingly expensive.
Longevity seekers must rely upon animal studies or markers of human aging to measure whether an intervention like daily resveratrol (rez-vair-ah-trol) consumption would be worthwhile
Will resveratrol pills significantly extend the healthspan and lifespan of humans? There may now be a partial answer to that question, though it takes reading some round-about science.
February 6, 2016: by Bill Sardi
Strikingly, researchers report that life-long administration of a modest dose of the red wine molecule resveratrol (rez-vair-ah-trol) given to laboratory mice keeps their visual system intact and retains their retinal sensitivity to light via activation of the Sirtuin1 survival gene. [Biochemical & Biophysical Research Communications 2015]
With advancing age the retinas of humans and animals lose sensitivity as measured by the electrical response of retinal cells (rods and cones) to light stimulation. But when these animals are given life-long (19 months, equivalent to ~65 years in a human) oral doses of resveratrol, their retinal sensitivity approximates a youthful state.