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How the world got lost on
the road to an anti-aging pill
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April 16, 2014: by Bill Sardi
At the first international resveratrol conference in Denmark (Resveratrol 2010) the working group stated that the evidence was “not sufficiently strong to justify recommendation for the chronic administration of resveratrol to human beings, beyond the dose which can be obtained from dietary sources.” [Annals N Y Academy Science 2013 Jul; 1290:1-11]
An often heard issue is the lack of bioavailability of resveratrol. This is caused by the attachment of detoxification molecules (sulfate, glucuronate) to resveratrol as it passes through the liver.
April 10, 2014: by Bill Sardi
Typically diabetics exhibit high circulating insulin levels and lack of sensitivity to insulin. The prospect of successfully employing resveratrol to treat diabetes is an ongoing quest that has been muddied by scientific studies that appear to have been designed to fail.
Recently researchers in Asia sorted out all the published studies involving resveratrol and diabetes and found that resveratrol remarkably controls blood sugar and insulin in diabetic individuals but has no effect among healthy individuals. [American Journal Clinical Nutrition, April 2014] That means resveratrol is an ideal blood sugar control agent as it doesn’t induce hypoglycemia (low blood sugar) when taken by healthy subjects.
April 7, 2014: by Bill Sardi
A Harvard Medical School geneticist is known as the pied piper of anti-aging pills. His latest speech delivered at the University of Nebraska Medical Center is captured in printed text and a 16-minute video by the Nebraska World-Herald, and can be accessed online here.
This boyish-faced Harvard prof first made a connection between a survival gene (Sirtuin1) and life-prolonging limited calorie diets and a red wine molecule (resveratrol) that activates the same gene in a NATURE journal report published in 2003.
March 31, 2014: by Bill Sardi
Longevinex® Achieves Age Reversal Effect Via Alternate Gene Pathway
Late last year when biologists announced in the journal CELL that a niacin-like molecule restores energy to aged cells, reversing markers of aging akin to making a 60-year old human 20-years old again, the mechanism described was attention getting.
Slowing the rate of aging desirable, though such an accomplishment has limited utility among those who have already lived most of their lives. The idea of a pill that can not only slow but also reverse aging has captured the attention of noted inventor and futurist Ray Kurzweil. This discovery means it is never too late in life to address aging with anti-aging strategies.
February 8, 2014: by Bill Sardi
Back in July of 2013 this writer rebutted a published report in The Journal of Physiology that resveratrol reversed the beneficial effects of exercise among healthy aged males. I wasn’t the only party who objected to the false conclusions made by researchers at the University of Copenhagen.
I noted that at no time did any of the measured numbers, cholesterol, blood pressure or blood sugar, fall outside the optimal range in the group that took resveratrol, though they were marginally different from males given a placebo pill. The conclusions drawn from this study, and the widespread news headlines that followed, were are giant misdirection.
January 5, 2014: by Bill Sardi
“Old age is the harbor
of all ills.” -Bion
January 3, 2014: by Bill Sardi
Recently researchers said they were able to reverse biological aging for the first time using a derivative of vitamin B3 niacin.
A report in the journal CELL noted that the use of a derivative of vitamin B3/niacin called nicotinamide stimulates the production of nicotinamide adenine dinucleotide (NAD), a key protein in cellular metabolism (use of sugar for cellular energy) and cellular respiration (use of oxygen for cellular energy) in the mitochondria of cells.
There are a few hundred mitochondria in living cells. Mitochondria are atomic power plants that produce cell energy in the form of adenotriphosphate (ATP). By molecularly promoting more NAD/ATP in the mitochondria researchers were able to demonstrate that aging largely occurs in the mitochondria rather than the nucleus of cells and that production of NAD was able to reverse aging in muscle tissue of a laboratory mouse equivalent to making a 60-year old human 20-years old again!
December 24, 2013: by Bill Sardi
When a Harvard biologist announced biological aging had been reversed in just one week by the use of a compound that invigorates energy-producing compartments called mitochondria inside living cells, the news was spread worldwide. But the bottom line lesson from this landmark study was to wait a few years for Big Pharma to develop an expensive prescription drug to duplicate this unprecedented experiment.
And indeed, the results of the experiment were extraordinary – the muscle tissue in an aged (22-month old) laboratory mouse reverted back to a more youthful state in just one week, equivalent to turning a 60-year old human back to being 20 again! (A technical abstract of the report is published at the journal CELL.) Now if we could only erase those wrinkles!
December 20, 2013: by Bill Sardi
November 8, 2013: by Bill Sardi
In 2003 when a Harvard professor first heralded resveratrol (rezvair-ah-trol) as the key molecule in red wine that was both responsible for the French Paradox (the fact the wine-drinking French experienced a far lower rate of mortality from coronary artery disease than North Americans) and it also molecularly mimics a calorie-restricted diet, one would have bet it would be an up and coming dietary supplement or maybe even an FDA-approved drug. It had been touted as the only molecule found to block the development of all three stages of cancer (initiation, growth and spread) in 1997.
But ten years later, after researchers repeatedly (and falsely) claimed resveratrol is not biologically available, and after it was intentionally overdosed animals and even humans to produce negative studies, and a leading researcher was falsely accused of scientific fraud, sales of this promising natural molecule are in steep decline. Three years ago sales of resveratrol supplements were estimated at $30,000,000 and have now dropped below $18,000,000.