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July 27, 2010: by ResveratrolNews
Experimental Gerontology, 2010
Niki Chondrogianni, , Suzanne Kapetaa, Ioanna Chinou, Katerina Vassilatou, Issidora Papassideri and Efstathios S. Gonos
a National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vassileos Constantinou Avenue, Athens 11635, Greece
b University of Athens, School of Pharmacy, Division of Pharmacognosy and Chemistry of Natural Products, Zografou Campus, Athens 15771, Greece
c Korres S.A. Natural Products, 57th Athens-Lamia National Road, 32011, Inofyta, Greece
d Department of Cell Biology and Biophysics, University of Athens, Athens, Greece
Received 20 January 2010;
revised 31 May 2010;
accepted 1 July 2010.
Available online 7 July 2010.
Homeostasis is a key feature of the cellular lifespan. Its maintenance influences the rate of ageing and it is determined by several factors, including efficient proteolysis. The proteasome is the major cellular proteolytic machinery responsible for the degradation of both normal and damaged proteins. Alterations of proteasome function have been recorded in various biological phenomena including ageing and replicative senescence. Proteasome activities and function are decreased upon replicative senescence, whereas proteasome activation confers enhanced survival against oxidative stress, lifespan extension and maintenance of the young morphology longer in human primary fibroblasts. Several natural compounds possess anti-ageing/anti-oxidant properties. In this study, we have identified quercetin (QUER) and its derivative, namely quercetin caprylate (QU-CAP) as a proteasome activator with anti-oxidant properties that consequently influence cellular lifespan, survival and viability of HFL-1 primary human fibroblasts. Moreover, when these compounds are supplemented to already senescent fibroblasts, a rejuvenating effect is observed. Finally, we show that these compounds promote physiological alterations when applied to cells (i.e. whitening effect). In summary, these data demonstrate the existence of naturally occurring anti-ageing products that can be effectively used through topical application.
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July 25, 2010: by Bill Sardi
Inquiry: Read an article in today’s NYT about Situin and it’s potential in preventing Alzheimer’s. Resveratrol was mentioned as promoting Sirtuin but the article was not clear if it did so past the brain/blood barrier. I would appreciate if you could shed some light on this.
Comment: First, I am obligated to say that at no time in my answer below am I suggesting any resveratrol-based dietary supplement is proven for the cure for a brain disorder like Alzheimer’s disease. It can only be said it is a very promising molecule in regard to aging in the brain.
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July 7, 2010: by Bill Sardi
Clusterin, a protein that appears to regulate both the toxicity and conversion of beta amyloid brain plaque into insoluble forms, hits the news pages this morning as a possible marker for Alzheimer’s disease. Elevated levels of clusterin in blood serum could predict Alzheimer’s disease years before its occurrence. The report is published in the July issue of Archives of Psychiatry.
According to The Alzheimer’s Society, clusterin levels were linked with the occurrence, progression and severity of the disease (shrinkage of the brain and memory impairment).
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June 17, 2010: by Bill Sardi
It has been a long time coming — since 2003 when Konrad Howitz PhD of Biomol and Dr. David Sinclair of Harvard Medical School first reported in Nature Magazine that yeast cells lived longer when given resveratrol, a red wine molecule — for human studies to ensue.
Publication of the first small studies involving resveratrol pills in humans appear to be encouraging, but obviously lack conclusiveness. It will take a few decades to convincingly prove a pill can reliably extend human life.
One of the markers of aging is inflammation. In fact, aging has been called “inflammaging.” Researchers at the State University of New York found that 40 milligrams of resveratrol taken daily by young adults for six weeks significantly reduces markers of inflammation (tumor necrosis factor-TNF, C-reactive protein – CRP) as well as measures of oxidation. An abstract of the study can be viewed online here.
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June 11, 2010: by Bill Sardi
Researchers in France have completed the first year of a 5-year study of 38-month old grey mouse lemurs, naturally found on the Island of Madagacar. These lemurs live generally 8-10 years and 5 years of study will likely provide sufficient data on longevity effects of a calorie restricted diet or its proposed molecular mimic, resveratrol.
The dose of resveratrol used in this study is beyond practicality in humans – 200 milligrams per kilogram (2.2-lbs) of body weight per day, or the human equivalent of 14,000 milligrams per day for a 70-kilogram (160-lb) human.
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: by Bill Sardi
Say again? Pterostilbene? (pronounced “tero-STILL-bean”) If you take resveratrol pills you probably have never heard of pterostilbene, but it is a naturally-occurring, molecular look-alike of resveratrol.
Pterostilbene is alleged to be superior to resveratrol and the commercial availability of a pure form of pterostilbene (pTeroPure) is creating some manufacturer-driven hype that consumers should opt for it over resveratrol.
The actual development of pterostilbene as a raw material for dietary supplements began with research conducted by US Department of Agriculture scientists. Pterostilbene is derived from blueberries. It’s being imported from India as a nearly pure extract.
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May 31, 2010: by Bill Sardi
The consumer shift to buying dietary supplements online complicates the problem of sorting out fact from fiction when it comes to dietary supplements. The internet has become an unbridled field for electronic fraud when it comes to dietary supplements, and online consumers continue to be suckered in by the thousands on a daily basis. There are many reasons for this.
First, government overseers have chosen to look the other way while outlaw companies on the internet make unsubstantiated claims for their products. The Federal Trade Commission says it will do nothing unless it receives one-hundred consumer complaints and the Food and Drug Administration only sends toothless correction letters in regard to labeling or advertising claims. Online marketers of dietary supplements know there is no cop on supplement boulevard to issue citations.
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: by ResveratrolNews
Dr. William Li heads the Angiogenesis Foundation in Boston, a nonprofit that is re-conceptualizing global disease fighting. Dr. Li presents a new way to think about treating cancer and other diseases using molecules like resveratrol, which prevent the undesirable growth of new blood vessels that feed a tumor. The crucial first (and best) step: Eating cancer-fighting foods that cut off the supply lines and beat cancer at its own game. http://www.ted.com/talks/lang/eng/william_li.html
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May 25, 2010: by Bill Sardi
“Wine is the greatest of medicines. Where wine is lacking, drugs are necessary.” -The Talmud
That is the question posed to physicians in the Journal of the American Medical Association Journal in its May 26 online issue. (May 26, 2010; Vol. 303, No. 2065-73)
The response, written by an accomplished physician, is reflective of the widespread void in applying nutritional medicine in cases such as this one. The doctor is a bit ambiguous in his answer to this question and can never fully explain why the wine-drinking French exhibit far greater longevity and lean body mass compared to North Americans.
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May 17, 2010: by Bill Sardi
A month doesn’t go by these days that some researchers don’t discover another genetic pathway that promotes longevity. This time it’s about the PTEN gene, said to be a tumor suppressor gene. The more active the PTEN gene, and the less active the ARRESTIN gene, the longer roundworms lived. Roundworms without their ARRESTIN gene live about 30% longer. This research is published in the May 14 issue of the Journal of Biological Chemistry.
While investigators claim their research may lead to molecules that inhibit ARRESTIN and activate PTEN, such molecules have already been identified – namely molecules commonly found in red wine and soybeans — resveratrol, quercetin and genistein.
Resveratrol continues to astound. Resveratrol has many gene targets where it has been demonstrated to exert broad biological activity as an anti-inflammatory, anti-clotting, anti-cholesterol, anti-depressant, anti-viral, anti-fungal, anti-bacterial, anti-brain plaque (beta amyloid), anti-obesity agent. These properties must be safely demonstrated in humans with doses that are proven to be safe. – ©2010 Bill Sardi, exclusively for Reserveratrolnews.com
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