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  • Resveratrol As Antibiotic

    July 6, 2012: by Bill Sardi

    Resveratrol might not kill off bacteria straight off, but it does inhibit the ability of germs to adhere to the tissue walls of the gut. This is the same way cranberry inhibits bacterial infection in the bladder. If bacteria can’t congregate and spread they will be killed off by roaming white blood cells. In an era of antibiotic resistance this information becomes more valuable. Certainly, those who consume red wine or resveratrol pills with meals reduce their risk of food poisoning.

    Journal of Agriculture & Food Chemistry

    2012 Jul 4. [Epub ahead of print]

    Resveratrol and some Glucosyl-, Glucosyl-acyl- and Glucuronide Derivatives Reduce E. coli O157:H7, S. Typhimurium and L. monocytogenes Scott A Adhesion to Colonic Epithelial Cell Lines.


    The efficacy of resveratrol and some glucosyl-, glucosyl-acyl and glucuronide derivatives inhibiting adhesion of Salmonella Typhimurium, Escherichia coli O157:H7 and Listeria monocytogenes Scott A to Caco-2 and HT-29 colonic cells was investigated. The three bacteria strains were capable of adhering to both colonic epithelial cell lines, which responded producing the pro-inflammatory interleukin 8 (IL-8). Adhesion inhibition of E. coli O157:H7 and S. Typhimurium to colonic cells was ≥60% and ≥40%, respectively, when resveratrol and most of the resveratrol derivatives were applied. Lower adhesion inhibition was observed for the bacteria with higher adherence potential, L. monocytogenes (≥20%). Resveratrol-3-O-(6′-O-butanoyl)--D-glucopyranoside (BUT) (50 and 100 µM) and resveratrol-3-O-(6′-O-octanoyl)--D-glucopyranoside (OCT) (50 μM) reduced IL-8 secretion by 100%. These results suggest that one mechanism for the beneficial attributes of resveratrol and especially the derivatives BUT and OCT could be the ability to reduce the adhesion and consequent pro-inflammatory cytokine production in intestinal epithelial cells in response to pathogen adhesion. The potential use of these compounds in the prevention of food-borne infections, intestinal homeostasis loss and inflammatory bowel diseases could be another step in finding coadjuvants or alternatives to antibiotic treatments.

    PMID: 22762450

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