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  • Niacin Cures NAD+ Deficiency

    May 9, 2020: by Bill Sardi

    Resveratrol elevates NAD + (Nicotinamide adenine dinucleotide), a molecule that is considered to have anti-aging properties via its elevation of cell energy.  IT has been said that “all roads to longevity lead to NAD+.” NAD+ that is naturally derived from niacin.  Resveratrol elevated NAD+ by a more powerful mechanism than niacin (vitamin B3).  Niacin precursors nicotinamide riboside (Niagen) and Nicotinamide Mononucleotide (NMN) are widely touted as dietary supplements as precursors of NAD+.  Sixty years of science points to a derivative of niacin, nicotinamide, that stimulates NAD+.  But the question remains: does plain niacin or niacinamide elevate NAD+ in a far more economical way?  We now have a definitive answer to that question.


    Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy


    • Mitochondrial myopathy patients have NAD + deficiency in muscle and blood
    • Niacin is an efficient NAD + booster in humans
    • Niacin improves muscle strength and fatty liver in mitochondrial myopathy
    • Niacin boosts muscle mitochondrial biogenesis and respiratory chain activity in humans


    NAD + is a redox-active metabolite, the depletion of which has been proposed to promote aging and degenerative diseases in rodents. However, whether NAD + depletion occurs in patients with degenerative disorders and whether NAD + repletion improves their symptoms has remained open. Here, we report systemic NAD + deficiency in adult-onset mitochondrial myopathy patients. We administered an increasing dose of NAD +-booster niacin, a vitamin B3 form (to 750–1,000 mg/day; NCT03973203) for patients and their matched controls for 10 or 4 months, respectively.

    Blood NAD + increased in all subjects, up to 8-fold, and muscle NAD + of patients reached the level of their controls. Some patients showed anemia tendency, while muscle strength and mitochondrial biogenesis increased in all subjects. In patients, muscle metabolome shifted toward controls and liver fat decreased even 50%. Our evidence indicates that blood analysis is useful in identifying NAD + deficiency and points niacin to be an efficient NAD + booster for treating mitochondrial myopathy.

    NADplus deficiency

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