Comprehensive Library Of Resveratrol News

Longevity researchers recently reviewed 7 studies that compared resveratrol to a calorie restricted diet in mice.  They concluded resveratrol only moderately mimics some of the aspects of a lifespan-doubling limited calorie diet and produces inconsistent results in humans.

In 2004 the world heard of the promise of super-longevity achieved via a small molecule found in red wine.  Our genes are modifiable, they are not fixed.  Humans can even reverse biological versus calendar aging.

In 2006 resveratrol was shown to improve the health and survival of laboratory mice on a high-calorie diet.

Oddly, the researchers concluded that resveratrol “may not  be suitable for the prevention of age-or-obesity-related diseases and claimed synthetic drugs like the antidiabetic drug metformin that has been tested to be superior to resveratrol.”  However, resveratrol “completely substitutes for insulin,” and works 50-200 times better than metformin.

But hopes of a longevity pill were dashed by a follow-up study in 2009 when resveratrol mimicked the epigenetic aspects of a calorie restricted diet but failed to extend the life of laboratory mice fed a normal calorie diet.

However, there are so many adults who over-eat, it is incredulous to believe such a pill wouldn’t benefit the many overweight and obese Americans.

One of the criticisms of resveratrol pills is that they don’t lower blood sugar levels in healthy animals and humans.  But if they did, they would crash blood sugar levels.  In healthy people, you don’t want to induce hypogylcemia.

The health benefits of red wine, particularly modest doses (1-2 glasses per day) has been positively associated with human health promotion.  Red wine drinkers live longer than teetotalers.

The health benefits of red wine exceed that of drinking grape juice.  It is the alcohol fermentation of the grapes that concentrates the molecules in red wine, like resveratrol.

Unfiltered wine provides 30 times more red wine molecules than filtered wines commonly provided today, about the amount provided in current nutraceuticals.

However, wine is not a concentrate of one molecule that is commonly tested in the animal lab.  Many other molecules in wine produce a synergistic effect, molecules like quercetin and fisetin.

In 2008 a resveratrol-based matrix of nutraceuticals was found to profoundly exceed the genetic activity produced by a calorie-restricted diet.  Calorie-restricted mice activated 298 genes; resveratrol-treated mice 325 genes; resveratrol matrix (Longevinex®)1711 genes (83% of the genes activated by a calorie-restricted diet).

It’s not like Longevinex® hasn’t been shown to be effective in humans.  The very earliest sign of blood vessel disease is inability of blood vessels to widen as the heart pumps faster and blood flow increases, a phenomenon called flow mediated dilatation.

Apparently Longevinex® increases levels of nitric oxide gas in arteries to widen blood vessels and help control blood pressure, particularly when under stress.  Longevinex® worked better than a larger dose of plain resveratrol.

Anti-aging researchers have their “not-invented-here” blinders on.  Given resveratrol abolishes most age-related disorders, it’s obvious research grants would dry up with announced cures.  What the public decides to do with this information is unknown.  Adult have been slow to adopt resveratrol pills into their daily health regimens.

There are roughly 13,000,000 Americans who have registered at the Dr. Pepper website.  There are only ~30,000 people in the world who regularly take a resveratrol pill.   Those who do have never regretted it.