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  • Decoding Biology: Skip The Idea Of Infusing Young Blood From Your Kids Into Grandpa And Advise Him To Take Resveratrol Pills

    May 5, 2014: by Bill Sardi

    Recently reported science suggests the idea of infusing young blood from grandchildren into their grandparents’ circulatory system would invigorate their memory and learning.  Nobody has suggested this be done yet in humans.  The experiments have been confined to laboratory animals.  But a review of the medical literature suggests there may be an easier way to do this using a red wine resveratrol pill.

    The recently reported science isn’t new but it is exciting.  Joining laboratory mice in old/young pairs by stitching their skin together with adjoined blood vessels has been demonstrated to renew the brains of older mice, proving that blood factors can produce younger functioning brains.

    The experiment was performed by researchers at the University of California San Francisco (UCSF) [Nature Medicine May 4, 2014] and is a follow-up study to earlier experiments published in 2011 [Nature August 31, 2011] and initially reported in 1960 by noted aging researcher Clive McCay. [Gerontologia 1960]

    The UCSF news release provides more information. (UCSF News May 4, 2014]  Researchers say the most exciting finding is that brain aging can be reversed.

    Hold up on those blood transfusions

    But before you think about coaxing your aging grandfather to receive blood transfusions from his grandchildren, you might try giving him a resveratrol pill.

    It turns out that youthful blood increases something called CREB (cyclic AMP response element binding protein) that targets the hippocampus, a lobe of the brain responsible for memory formation and that is particularly vulnerable to age-related impairment of communication between brain cells.  Youthful factors in young blood improved brain plasticity of laboratory animals. Plasticity is the ability of the brain to develop new electrical connections.

    Resveratrol increases CREB

    Now there is recent scientific evidence that the red wine molecule resveratrol (pronounced rez-vair-ah-trol) activates CREB in young animal brains and prevents impaired thinking when under stress.  [Progress Neuropsychopharmagology Biological Psychiatry March 2014]

    There is also evidence that resveratrol elevates CREB in laboratory animals and prevents brain injury from experimentally induced blockage of blood circulation.  [Journal Molecular Neuroscience July 2013]  Earlier experiments also confirm that scientific finding. [European Journal Neuroscience Oct 2012]

    Resveratrol also activates CREB and protects against damage in models of experimental heart attack.  [American Journal Physiology Heart Circulatory Physiology Jan 2005]

    Resveratrol activates CREB via a known genetic pathway called PGC-1 alpha [Experimental Gerontology Sept 2008] and via other biological pathways.  [Journal Pharmacology Experimental Therapeutics August 2005]

    It has also been demonstrated that resveratrol via activation of CREB increases brain-derived neurotrophic factor that protects brain tissue from damage.  [Experimental Biology Medicine Aug. 2012]

    Dose must be low

    Biologists have known for some time now that molecules that mildly stress living organisms can protect against cellular and tissue damage and prolong lifespan via activation of CREB.  These biological stressing agents must be given in relatively low doses to be effective. [Trends Neuroscience Nov. 2006]

    Researchers caution consumers over taking too much resveratrol, in doses up to 500 milligrams, may negate its positive effects and can even reduce brain activity via suppression of CREB. [Journal Biological Chemistry Dec. 2012]

    Activation of CREB via the PGC-1 alpha genetic pathway is known to reinvigorate the cell energy compartments known as mitochondria, considered to be important for proper brain function in older aged individuals.  [Experimental Gerontology Sept. 2008]

    The only commercially available low-dose resveratrol pill that has undergone dosage testing and been shown to activate CREB via PGC-1 alpha is Longevinex®.  [Experimental Gerontology Sept. 2008]  Longevinex® has been demonstrated to renew and reinvigorate cellular mitochondria via the Sirtuin3 survival gene three times better than plain resveratrol at a low dose.  [ResveratrolNews Jue 30, 2011]  — © 2014 Bill Sardi,


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