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  • Relatively Low-Dose Resveratrol, But Not High Dose, Reverses Chemically-Induced Gastric Ulcers

    March 31, 2009: by ResveratrolNews

    For the first time researchers have demonstrated that relatively low doses of the red wine molecule resveratrol (rsz-vair-ah-trawl) reverse chemically-induced gastric ulcers in animals.  Higher-doses of resveratrol delayed but did not prevent or reverse tissue damage.

    Researchers induced gastric ulcers in laboratory animals by administering high doses of indomethacin, an anti-inflammatory drug known to irritate the gastric mucus lining.  Mice were given resveratrol orally at different doses.  The results were as follows:

    Effects of Resveratrol on Chemically-Induced (Indomethacin) Gastric Ulcers

    (Chemical damage peaked on the 4th day and natural healing began on the 7th day)

    Dosage per kilogram (2.2 lbs) of body weight Human equivalent dose for 70 kilogram (160-lb) human Damage caused by gastric ulcer*

    (low # is best)

    on 4th day

    Inflammatory marker (myeloperoxidase enzyme) at 4 days

    (low # is best)

    Untreated 2.839 3.800
    0.5 mg 35 mg 2.826 3.804
    1.0 mg 70 mg 2.130 2.340
    2.0 mg 140 mg 1.256 1.926
    3.0 mg 210 mg 2.866 3.638
    5.0 mg 3500 mg 2.856 4.005
    10.0 mg 7000 mg 3.760 4.250
    Ulcer-healing drug (misoprostol) 0.564 0.980
    * The damage score (DS) was assessed by grading the gastric injury on a 0_4 scale, based on the severity of hyperemia and hemorrhagic erosions:  0—almost normal mucus layer, 0.5—hyperemia, 1—one or two lesions,
    2—severe lesions, 3—very severe lesions, and 4—mucosa full of lesions

    Source:  Anindya Dey, Prasun Guha, Subrata Chattopadhyay, Sandip K. Bandyopadhyay, Biphasic activity of resveratrol on indomethacin-induced gastric ulcers. Biochemical and Biophysical Research Communications 381 (2009) 90–95.

    Copyright 2009  Not for reproduction or posting on other websites.

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