test your knowledge
How the world got lost on
the road to an anti-aging pill
Subscribe to our newsletter to receive email notifications when new articles are posted.
March 31, 2009: by ResveratrolNews
For the first time researchers have demonstrated that relatively low doses of the red wine molecule resveratrol (rsz-vair-ah-trawl) reverse chemically-induced gastric ulcers in animals. Higher-doses of resveratrol delayed but did not prevent or reverse tissue damage.
Researchers induced gastric ulcers in laboratory animals by administering high doses of indomethacin, an anti-inflammatory drug known to irritate the gastric mucus lining. Mice were given resveratrol orally at different doses. The results were as follows:
|Effects of Resveratrol on Chemically-Induced (Indomethacin) Gastric Ulcers
(Chemical damage peaked on the 4th day and natural healing began on the 7th day)
|Dosage per kilogram (2.2 lbs) of body weight||Human equivalent dose for 70 kilogram (160-lb) human||Damage caused by gastric ulcer*
(low # is best)
on 4th day
|Inflammatory marker (myeloperoxidase enzyme) at 4 days
(low # is best)
|0.5 mg||35 mg||2.826||3.804|
|1.0 mg||70 mg||2.130||2.340|
|2.0 mg||140 mg||1.256||1.926|
|3.0 mg||210 mg||2.866||3.638|
|5.0 mg||3500 mg||2.856||4.005|
|10.0 mg||7000 mg||3.760||4.250|
|Ulcer-healing drug (misoprostol)||—||0.564||0.980|
|* The damage score (DS) was assessed by grading the gastric injury on a 0_4 scale, based on the severity of hyperemia and hemorrhagic erosions: 0—almost normal mucus layer, 0.5—hyperemia, 1—one or two lesions,
2—severe lesions, 3—very severe lesions, and 4—mucosa full of lesions
Source: Anindya Dey, Prasun Guha, Subrata Chattopadhyay, Sandip K. Bandyopadhyay, Biphasic activity of resveratrol on indomethacin-induced gastric ulcers. Biochemical and Biophysical Research Communications 381 (2009) 90–95.
Copyright 2009 Not for reproduction or posting on other websites.