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March 31, 2009: by ResveratrolNews
For the first time researchers have demonstrated that relatively low doses of the red wine molecule resveratrol (rsz-vair-ah-trawl) reverse chemically-induced gastric ulcers in animals. Higher-doses of resveratrol delayed but did not prevent or reverse tissue damage.
Researchers induced gastric ulcers in laboratory animals by administering high doses of indomethacin, an anti-inflammatory drug known to irritate the gastric mucus lining. Mice were given resveratrol orally at different doses. The results were as follows:
| Effects of Resveratrol on Chemically-Induced (Indomethacin) Gastric Ulcers
(Chemical damage peaked on the 4th day and natural healing began on the 7th day) |
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| Dosage per kilogram (2.2 lbs) of body weight | Human equivalent dose for 70 kilogram (160-lb) human | Damage caused by gastric ulcer*
(low # is best) on 4th day |
Inflammatory marker (myeloperoxidase enzyme) at 4 days
(low # is best) |
| Untreated | – | 2.839 | 3.800 |
| 0.5 mg | 35 mg | 2.826 | 3.804 |
| 1.0 mg | 70 mg | 2.130 | 2.340 |
| 2.0 mg | 140 mg | 1.256 | 1.926 |
| 3.0 mg | 210 mg | 2.866 | 3.638 |
| 5.0 mg | 3500 mg | 2.856 | 4.005 |
| 10.0 mg | 7000 mg | 3.760 | 4.250 |
| Ulcer-healing drug (misoprostol) | — | 0.564 | 0.980 |
| * The damage score (DS) was assessed by grading the gastric injury on a 0_4 scale, based on the severity of hyperemia and hemorrhagic erosions: 0—almost normal mucus layer, 0.5—hyperemia, 1—one or two lesions, 2—severe lesions, 3—very severe lesions, and 4—mucosa full of lesions |
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Source: Anindya Dey, Prasun Guha, Subrata Chattopadhyay, Sandip K. Bandyopadhyay, Biphasic activity of resveratrol on indomethacin-induced gastric ulcers. Biochemical and Biophysical Research Communications 381 (2009) 90–95.
Copyright 2009 Not for reproduction or posting on other websites.
Posted in Resveratrol
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