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  • Resveratrol Trumps Curcumin

    September 17, 2020: by Bill Sardi

    But What Has That Got To Do With Coronavirus?

    So, here is an important report for resveratrol users.  Resveratrol, but not curcumin – – a widely-sold remedy for joint pain, reduces inflammation and muscle loss among laboratory animals with experimentally-implanted tumors.  End of story.

    At this current moment in time, who cares?  COVID-19 coronavirus may kill us before we ever get cancer.

    Today Americans live with fear in their hearts, fear of an invisible virus that threatens everyone’s lives.  At least that is what public health officials have stated.

    It would be nice to take an anti-aging pill but right now humanity has to dodge an immediate viral bullet headed its way.  Fortunately, resveratrol doesn’t disappoint.

    Versatile resveratrol

    Resveratrol is a strong antiviral agent as well as a mimic of a calorie-restricted diet that has been shown to double the lifespan and healthspan of lab animals.  But that is a discovery of the past.  The world’s human populations are white-knuckled over that #19 coronavirus.

    What do you mean we are already immune?

    Well, the scaremongering news media forgot to tell you almost everybody has been infected and most people already exhibit immunity to towards this man-made monster virus.  Maybe vaccination will be superfluous.

    Dr. Johan Giesecke, professor emeritus at the Karolinska Institute in Stockholm, says:

    The lockdown only pushes severe cases and deaths into the future, it will not prevent them.

    “Everyone will be exposed to COVID-19 coronavirus and most people will become infected.  COVID-19 is spreading like wildfire in all countries, but we do not see it – it almost always spreads from younger people with no or weak symptoms to other people who will have mild symptoms… there is very little we can do to prevent this spread… I expect the number of deaths from COVID-19 will be similar regardless of measures taken… it is not certain vaccines will be very effective.”

    The vanishing prospect of a vaccine

    Given that no one has been able to develop an effective vaccine against any coronavirus in the past decade, even the FDA lowered its requirement for licensure of a COVID-19 vaccine – – it will only need to prevent or reduce the severity of the disease in 50% of infected individuals.  (, Guidance For Industry, page 14)

    Given the efficacy of the flu vaccine has only exceeded 50% four times in the past 15 years, what likelihood is there for a coronavirus vaccine to achieve licensure?

    The promise of a vaccine may be moot because so many are already immune, combined with the realization a there may never be a safe and effective coronavirus vaccine.

    It is surprising to find more than 90% of human populations are already positive for at least three of the “common cold” coronaviruses and prior infections afford immunity from COVID-19.  Furthermore, 90% of individuals who test positive for COVID-19 may not be carrying enough of it to infect anyone else.

    Have we all developed COVID-19 cell killing T-cells?

    Your own immune system is likely to have already made virus-killing, zinc-dependent T-cells that afford long-term immunity.

    Then another startling fact: “Everyone who gets COVID-19, even people with mild or asymptomatic cases, develop zinc-dependent T cells that can hunt down the coronavirus if they get exposed again years later.”  Gee, why didn’t they tell us?

    Remarkably, resveratrol activates T-cells and along with zinc helps to produce long-term immunity.

    While it is believed herd immunity kicks in when 60-70% of the population has developed immunity, under certain circumstances, herd immunity may be realized once 10—20% of individuals are immune.  Will we even need a vaccine?

    A sigh of relief

    I can hear a sigh of relief from concerned readers here.  So, with the threat of the COVID-19 coronavirus becoming increasingly remote, can we get back to talking about resveratrol?

    Both resveratrol and COVID-19 puts doctors out of business

    Resveratrol is like COVID-19.  If resveratrol were adopted by American medicine it would put as many doctors out of business as the lockdown for COVID-19 did.

    The red wine molecule resveratrol has been pushed aside so many times, for good reason.  It threatens to single-handedly put pharmaceutical companies out of business.  No one should expect doctors and hospitals nor pharma companies to put themselves out of business.  So, the idea of first running to the doctor for every ailment then becomes unwise.  Home remedies should be primary care.

    Searching for safe and effective alternatives should be standard practice.  Remember, there is still no vaccine or approved medicine for COVID-19 coronavirus.  So, Americans have no other option than to search for natural alternatives at this point in time.

    Survival and longevity

    Resveratrol over both immediate and long-term benefits

    Not only does resveratrol act to kill coronavirus-infected cells, but by virtue of its ability to chelate (attach to) copper and mimic a calorie-restricted diet, it promises to allay most all age-related diseases.  It would replace many of the top 50 prescription drugs.

    And resveratrol synergizes vitamin D by sensitizing the vitamin D receptor (vitamin D doorway on the surface of living cells), vitamin D being cited as a nutrient that dramatically lowers severity of COVID-19 infections.

    What if already infected?

    But what if you are already infected with COVID-19 coronavirus?

    Immunity towards COVID-19 from ever infecting humans is one thing, but calming down the cytokine (sigh-toe-keen) storm in the lungs once a person is infected is another.  Yes, resveratrol once again shows it can reduce an over-active immune system (autoimmunity).

    Sigh of relief

    OK, so now resveratrol pill users can stop holding their breath with the realization that healthy individuals are at an over-presumed risk to become ill from COVID-19 and resveratrol is a front-line COVID-19 coronavirus stopper along with zinc and vitamin D.

    Curcumin vs. resveratrol

    So, what was that in the headline above about resveratrol trumping curcumin, the widely-sold anti-inflammatory herb derived from turmeric spice?

    Well, it turns out the body makes a transient gas called nitric oxide that sends a protective survival signal throughout the body when it is biologically stressed and dilates (widens) blood vessels to promote circulation.  But nitric oxide, an oxidant (rusting agent) has a Janus fact – – it can activate potentially destructive oxidation from nitrogen gas via superoxide, which is a potentially destructive molecule derived from oxygen.

    Alcohol activates nitric oxide gas, but it is well established alcohol is very problematic.  So, is nitric oxide gas good or bad for you?

    Resveratrol is known to increase the production of nitric oxide, but does so in a different way than alcohol.  Resveratrol binds to nitric oxide and prevents the activation of the potentially destructive superoxide radical.  By virtue of resveratrol’s ability to negate superoxide, it therefore increases the bioavailability of nitric oxide.

    Why wine but not alcohol spirits are protective

    This may be why wine but not vodka has some protective properties to counter the alcohol, particularly aged wine that has greater concentration of polyphenols like resveratrol, or unfiltered wine which provides 30-times more polyphenols.

    Therefore resveratrol, while being an activator of nitric oxide, is also the antidote against the superoxide radical that alcohol generates and therefore may prevent or minimize damage to the heart, lungs, brain and other organs.

    Superoxide is a potentially destructive oxygen-derived molecule that induces inflammation and joint degradation in arthritis.

    With this understanding, we now read a recent research study where resveratrol “dramatically reduces nitric oxide cell death (apoptosis)” in cells that produce cartilage in joints.


    So, in regard to joint health, how does resveratrol compare to curcumin, another polyphenol extracted from turmeric spice which is widely sold as a joint pain remedy?

    The answer to that question was provided in a study conducted in 2004.  Curcumin, even when given in high doses, was totally ineffective in preventing muscle degradation and accompanying weight loss among animals with an experimentally implanted tumor.  Cancer, in its unceasing quest to grow, utilizes sugars and finally protein from muscle as a growth factor, which leads to the weight loss observed in cancer patients (called cachexia).

    Resveratrol, at a dose 150-300 times lower than curcumin, minimized protein degradation and weight loss.

    Fortunately, there is a large body of evidence in human studies that curcumin protects joints and relieves joint pain, so users aren’t wasting their money.   But very large doses have to be used.

    Resveratrol, by virtue of its simultaneous ability to generate nitric oxide but counter the destructive effects of accompanying superoxide, is a potential antidote against age-related or autoimmune-induced joint degradation and muscle wasting in the case of cancer.

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