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  • Resveratrol Serves To Allay Anxiety & Mental Depression Via A Newly Discovered Pathway

    July 30, 2019: by Bill Sardi

    Researchers now say the red wine molecule resveratrol “opens a new door for depression and anxiety” treatment because it has been found, for the first time, to shut off an enzyme in the brain thought to excite these adverse mental states.  Resveratrol is non-prescription and non-addictive and according to data accumulated by the Poison Control Centers of America over the past decade, very safe.  A just-published laboratory study in the journal Neuropharmacology confirms resveratrol convincingly inhibits anxiety/depression-like behavior in mice.  Animals could handle stress better.

    Wine won’t do

    While news headlines suggest wine as a mood booster, at best a bottle of wine will only deliver a milligram or two of resveratrol.  But in a dose equivalent to a few hundred bottles of wine, achievable with resveratrol dietary supplements, a desirable mood-lifting/ anxiety-relieving effect may be achieved in humans, if this animal data can be applied to humans.

    Concentrated resveratrol produces a desirable mental state without any of the adverse effects of alcohol.  As a person consumes more and more wine with dinner and approaches inebriation they fall into somnolence – a sleep that produces a hangover when awakened the next morning.  The somnolence is induced by alcohol tickling the GABA receptor on brain cells.  GABA (gamma-aminobutyric acid) is a neuro-transmitter (chemical that runs from one brain cell to the next) that inhibits activity of nerve cells.  GABA and its receptor (cellular doorway) represent the addictive aspect of alcohol.

    Biologists used to think that excessive cortisone, a stress hormone produced in the adrenal glands, heightens fears and alertness but also can induce anxiety.  A new discovery is that it is not cortisone but an enzyme released by cortisone called phosphodiesterase 4 or PDE4 (fos-fo-di-ester-ace) that is actually to blame for anxiety and depression.  PDE4 inhibitors like the anti-depressant drug Rolipram are widely used.  Resveratrol is a potent PDE4 inhibitor.

    Resveratrol has been widely extolled as a preventive for Alzheimer’s memory loss and its PDE4 inhibition is key to producing this beneficial effect.

    PDE4 inhibitors also help prevent colon/rectal cancer in the animal lab, adding to potential benefits delivered by resveratrol.

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