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How the world got lost on
the road to an anti-aging pill
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May 2, 2018: by Bill Sardi
It is true that laboratory mice engineered to lack telomerase, an enzyme that facilitates lengthening of end-caps (telomeres) on chromosomes (bundles of DNA), became prematurely decrepit. But can human aging be slowed by elevation of telomerase activity? Probably not, because the decrepit mice were not normal mice. These animals were “grossly abnormal” and genetically engineered to age prematurely. What has been demonstrated in the laboratory may not apply to humans.
But research that is headed nowhere continues. No telomere anti-aging drugs have been developed. But researchers will do anything to get another research grant. So yet another report that speculates telomerase is the fountain of youth was recently published and made headlines news.
Read the whole post »
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April 19, 2018: by Bill Sardi
The medical research community now talks of moonshots (big leap-forward cures), regenerative medicine, precision individualized medicine, even one-time complete treatment cures. It is all part of the 21st Century Cures Act, which spreads $4.8 billion of research funding in an attempt to accelerate the development and approval of real cures. But will this Herculean effort bankrupt insurance pools?
The money is being directed toward expensive pharmacological cures that will further burst the Medicare Trust fund. Gobs of federal money are going towards innovations, like CRISPR gene therapy, that intends to completely remedy single-gene mutation diseases like cystic fibrosis, sickle cell, Huntington’s disease, and muscular dystrophy, all cured in a single treatment. But at what cost?
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: by Bill Sardi
Modern medicine likes to pull off hoaxes, like the great cholesterol hoax that is still in play after four decades. It likes to produce expensive cures on deliver them on its own terms. Inexpensive remedies are shunned, go untested, are said to be unproven (but not disproven), and are peddled by hucksters.
Now that you have that straightened out in your mind, you will love/loathe to hear that humans are about to be genetically edited. No, this is not an attempt to build a super-race of humans. But it is, well, a bit of an expensive scientific high-wire act that will be used to “cure” a blood disorder.
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April 16, 2018: by Bill Sardi
The human body and all living creatures for that matter have a biological clock entranced and synchronized by day and night (light and dark) cycles, what is called the 24-hour circadian rhythm. As humans age their inability to maintain synchronous sleep/wake cycles shortens lifespan. It is no surprise then to learn that with advancing age those individuals who retain uninterrupted nighttime sleep cycles tend to live longer.
Likewise, exposure of animals to artificially short or long light/dark cycles shortens their lifespan.
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April 13, 2018: by Bill Sardi
Over a decade ago genetic researchers claimed niacin (vitamin B3), being ubiquitously found in food, serves as a “found-food signal” while resveratrol, a red wine molecule, serves to produce a “food deprivation” signal that mimics a calorie restricted diet. We were told resveratrol activates the Sirtuin1 survival gene whereas niacin shuts it off. However, we are now told the niacin derivative NAD boosts Sirtuin1 gene protein levels.
Fast forward to today. The target of life-prolonging calorie-restricted diets is NAD –nicotinamide adenine dinucleotide. Resveratrol is now considered passé. Niacin derivatives are posed as “beyond resveratrol” pills. This is despite the fact resveratrol is probably a more powerful NAD booster.
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March 27, 2018: by Bill Sardi
Resveratrol continues to astound. Now if modern medicine would only take it out of the research closet and make it applied medicine.
Chemobrain is a symptom reported by many cancer patients with difficulty processing information. Symptoms of chemobrain include fatigue, confusion, mental fogginess, short attention span, short-term memory problems, recall and memory, difficulty concentrating. In an animal model of chemobrain, laboratory mice received injections of three cancer drugs, taxotere (docetaxel), doxorubicin (Adriamycin), cyclophosphamide (Cytoxan), preceded by one week of resveratrol treatment. Resveratrol resulted in far less brain inflammation and other interference of brain activity. According to the Mayo Clinic, no cure for chemobrain is at hand.
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March 20, 2018: by Bill Sardi
As expressed in a recent published report entitled “Past, Present, and Future of Healthy Life Expectancy,” it has become apparent the current “disease model” paradigm in healthcare may have to be abandoned and replaced by a “delayed aging” approach because of the large number of chronic comorbidities inflicting older people.
Caring for millions of senior Americans with chronic brain, eye and heart disease would be so overwhelming as to drain insurance pools as well as incapacitate society. Given that most chronic disease among senior adults is caused by aging, any technology that slows aging would delay the onset of physically or mentally debilitating diseases.
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March 9, 2018: by Bill Sardi
What causes cancer? Or more important, what un-causes cancer?
In widespread circulation on the worldwide web today (March 7) is investigative reporter Jon Rappoport’s coverage of the work of cancer researcher David Rasnick PhD. Rasnick proposes cancer does not emanate from accumulated gene mutations as commonly believed but rather from unbalanced chromosomes. Dr. Rasnick attempts to raise funds to complete his book on this topic (Precarious Balance: What Cancer Really is)
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March 8, 2018: by Bill Sardi
I’m of cataract age (in my early 70s). (cataract = cloudy focusing lens)
I’ve got clear lenses, no glaucoma (elevated fluid pressure); no other eye conditions typical for my age.
My retina scans you can see below.
My central retinal thickness is 255-256 right and left eye micrometers, about normal.
It would be typical for a 70+ year old to have drusen (oxysterol aka cholesterol) deposits at the back of my eyes. The scan below shows zero drusen.
My optic nerve and blood vessels are healthy.
I have habitually worn UV-blue-blocking sun lenses when outdoors during the day since age 40.
I have been supplementing my diet with lutein since 1992 when lutein first became available as a dietary supplement.
I take resveratrol since 2004 when it was popularized as an anti-aging molecule.
I have taken IP6 rice bran, an iron chelator, since the mid 1990s.
My vision is 20/30 in both eyes and I needed a prescription for astigmatism (irregular curvature of the front cornea of the eyes).
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February 26, 2018: by Bill Sardi
A recent report published in the journal Biomolecules and Therapeutics reveals the unparalleled ability of two natural molecules to address symptoms caused by diabetes.
Two natural molecules, quercetin and resveratrol, when used together are being extolled for their synergistic ability to quell the metabolic problems posed by diabetes and the drugs used to treat the disease. Undesirable side effects that accompany most anti-diabetic drugs (weight gain, low-blood sugar and death of insulin-making cells in the pancreas) as well as complications in other organs (kidneys and liver) prompt researchers to search for less problematic alternatives.
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