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How the world got lost on
the road to an anti-aging pill
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October 30, 2018: by Bill Sardi
While the cancer research community is furiously working to develop synthetic micro-RNAs that will selectively kill cancer cells, the red wine molecule resveratrol appears to naturally activate a cancer kill switch that is being heralded today as an alternative to toxic chemotherapy.
Scientists now say they have found a sequence of three nucleotides (steps on the RNA ladder) that kill cancer cells by virtue of their ability to eliminate three survival genes. The proposed treatment is called DISE (Death Induced by Survival Gene Elimination).
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October 22, 2018: by Bill Sardi
Over 7 million results for “resveratrol” on the Google search engine. Sixty years of research; 133 human clinical trials; twenty thousand (20,000) published research papers plus symposia, conferences, patents and attempts to produce analog drugs (synthetic resveratrol-like molecules). Doses ranging from 5-5000-milligrams have been put to the test in humans. This is what a recent landmark retrospective report reveals (Biomolecules & Therapeutics, Oct. 2018). But that portrayal of resveratrol needs to be re-written not only to correct misinformation but to reveal valid science that modern medicine has never dared to put into practice.
The author of that report is a leading researcher whose groundbreaking research opened the door to study resveratrol. His worldwide investigation on behalf of the American Cancer Society concluded that among all of the thousands of natural molecules studied, resveratrol deserved singular attention because it halted cancer at all three stages of development – initiation, growth and metastasis (spread), something no existing cancer drug can say some two decades later. The author, Professor John M. Pezzuto PhD, has written 38 published papers about resveratrol since 1997 and has applied for a number of patents as well.
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August 15, 2018: by Bill Sardi
Longevity seekers, don’t be fooled by news headlines that now talk about reversing aging in living cells with synthetically created molecules.
Anti-aging researchers are lauding themselves for reversing aging in living cells. One researcher said: “When I saw some of the cells in the culture dish rejuvenating I couldn’t believe it. The old cells were looking like young cells. It was like magic.” (Readers can now offer applause.)
Researchers are talking about restoration of something called splicing factors that facilitate the prolongation of telomeres, those end caps on chromosomes and delay or even reverse cells from becoming senescent – the cells stop dividing and replicating. Synthetic compounds were reportedly used to reduce cell senescence by up to 50%.
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July 25, 2018: by Bill Sardi
Well, it took 14 years for the research community to conduct a simple human study to determine if resveratrol raises Sirtuin1 gene protein blood levels as well as a calorie restricted diet. The study was conducted among healthy or slightly overweight subjects. Since blood measures of cholesterol, insulin and blood sugar were already within the healthy range in these subjects, neither a limited calorie diet nor resveratrol had any significant effects upon these measures, nor upon heart rate, weight, waist circumference or blood pressure.
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July 11, 2018: by Bill Sardi
A news report is making resveratrol pill users wonder whether they are using the best form of this molecule for their health. Scientific debate continues over whether a form of resveratrol that is advertised to be more bioavailable (pterostilbene) is superior to plain resveratrol.
As background information, resveratrol is a molecule that human body perceives as a toxin and seeks to detoxify it as it passes through the liver. Resveratrol is an antioxidant when given in modest doses (100-350 mg) but promotes oxidation when given in mega-doses (2800 mg).
For example, a human equivalent dose of 2800 mg was shown to increase the size of a heart attack (area of damaged heart muscle) whereas a modest dose decreases the area of damage. In fact, 2800 mg resveratrol actually “kills” a pumping rodent heart. However, when resveratrol is complexed with quercetin and rice bran IP6 (Longevinex®) there is no cardiac toxicity whatsoever (see chart below), making Longevinex® the safest resveratrol pill available should mega-doses be mistakenly consumed.
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June 29, 2018: by Bill Sardi
As I write on this 4th of July 2018 so many questions flood my mind regarding human longevity. Where is humanity headed? One unquestionable direction is, despite the vast majority of humans on the planet live in poverty and suffer from malnutrition, is that people are reported to be living far longer in developed countries. How much longer? Well, maybe just ten years.
Life expectancy is not an accurate measure of longevity because it is skewed downward by infant mortality. What is instructive is global life expectancy at age 60, which is tabulated at Global Watch Index.
Data tabulated for 2015 shows in a number of advanced countries, people at age 60 are likely to live another 25 years or so (tops is Japan at 26 years; US 23 years) whereas in undeveloped lands, people reaching age 60 are likely to live another 15 years. So the net lifespan gain accomplished by access and delivery of modern medicines, antibiotics, etc. is about 10 years when population groups are compared.
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May 24, 2018: by Bill Sardi
If a newly published report is correct, that resveratrol (rez-vair-a-trol) dietary supplements are based upon on thread-thin if not altogether bogus science, I ought to be confessing I’m a charlatan and snake oil salesman and resign from my self-appointed position as defender of res-pills and editor at ResveratrolNews.com
The latest knife that has been thrown at resveratrol comes from a doctor-run website that claims it is an authoritative non-commercial source of information on topics like resveratrol. The NutritionFacts.org website accepts no advertising and has no hidden sponsors. There is no product line of dietary supplements that are being sold covertly at “SnakeOilWondersupplements.com.” We are all pleased to hear that.
Anyone who has commercial interest in resveratrol pills, like myself, is biased I guess. Yes, after living 73 years without any evident disease or need for medication, without a hint of a cloudy cataract or cholesterol (drusen) deposits at the back of my eyes that are apparent in 91% of adults my age, I guess I am biased.
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May 11, 2018: by Bill Sardi
The use of 100 milligrams of supplemental resveratrol (rez-vair-a-trol) among post-stroke patients (average age 65) improves all measures of health compared to standard medical treatment including body mass index, blood pressure, cholesterol, blood glucose and hemoglobin A1c, a measure of long-term blood sugar control.
In some patients resveratrol was instituted months after the occurrence of a stroke but still produced a positive result. No strokes reoccurred during the study period in any group (control group/standard medical treatment or resveratrol group).
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May 2, 2018: by Bill Sardi
It is true that laboratory mice engineered to lack telomerase, an enzyme that facilitates lengthening of end-caps (telomeres) on chromosomes (bundles of DNA), became prematurely decrepit. But can human aging be slowed by elevation of telomerase activity? Probably not, because the decrepit mice were not normal mice. These animals were “grossly abnormal” and genetically engineered to age prematurely. What has been demonstrated in the laboratory may not apply to humans.
But research that is headed nowhere continues. No telomere anti-aging drugs have been developed. But researchers will do anything to get another research grant. So yet another report that speculates telomerase is the fountain of youth was recently published and made headlines news.
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April 19, 2018: by Bill Sardi
The medical research community now talks of moonshots (big leap-forward cures), regenerative medicine, precision individualized medicine, even one-time complete treatment cures. It is all part of the 21st Century Cures Act, which spreads $4.8 billion of research funding in an attempt to accelerate the development and approval of real cures. But will this Herculean effort bankrupt insurance pools?
The money is being directed toward expensive pharmacological cures that will further burst the Medicare Trust fund. Gobs of federal money are going towards innovations, like CRISPR gene therapy, that intends to completely remedy single-gene mutation diseases like cystic fibrosis, sickle cell, Huntington’s disease, and muscular dystrophy, all cured in a single treatment. But at what cost?
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