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  • New High Fructose Corn Syrup Antidote: Add Resveratrol

    April 3, 2012: by Bill Sardi

    The scourge of making a cheap sugar from corn is the prevalent plague of diabesity that has changed American waist lines and forced many into life-long insulin injections. An antidote to high fructose corn syrup (HFCS) would be ideal if Americans can’t back away from their desire for sweets. Sugars do create cravings for more sweet stuff as sugar-craving yeast overgrow in the digestive tract. About 50% of sugar intake in western society is derived from HFCS sugar in soft drinks. Certainly Americans have become hooked on this cheap sugar and are paying the price not only with poor health but rising health care costs. And to think HFCS was developed by none other than the US Department of Agriculture. So researchers in Eastern Europe put resveratrol, known as a red wine molecule, to the test to see if it would counter the adverse effects of HFCS. Whereas HFCS causes triglycerides and very-low density lipoproteins (cholesterol) to rise as well as blood pressure and insulin levels in laboratory rats, resveratrol supplementation “efficiently restored HFCS-induced deteriorations” said researchers. Here is the comparative data:

    Low HFCS High HFCS HFCS + Resveratrol
    Triglycerides 124 223 91
    Insulin 0.93 1.09 0.74
    VLDL cholesterol 24.8 44.8 18.2
    Blood pressure 118.6 163.6 140.5

    This is pretty convincing data though it is produced in the animal lab where mega-dose HFCS is given to provoke an adverse effect and where fairly strong concentrations of resveratrol are employed as a food additive. In limited human studies, such beneficial effects have not been measured as yet. But the day may come when soft drink bottles might say “Coca Cola with added resveratrol.” –Copyright 2012 Bill Sardi,

    Food Chem Toxicol. 2012 Mar 23. [Epub ahead of print]

    High-fructose corn syrup causes vascular dysfunction associated with metabolic disturbance in rats: Protective effect of resveratrol.

    Akar F, Uludağ O, Aydın A, Aytekin YA, Elbeg S, Tuzcu M, Sahin K.


    Department of Pharmacology, Faculty of Pharmacy, Gazi University, Etiler, Ankara, Turkey.


    High-fructose corn syrup (HFCS) is used in many prepared foods and soft drinks. However, limited data is available on the consequences of HFCS consumption on metabolic and cardiovascular functions. This study was, therefore, designed to assess whether HFCS drinking influences the endothelial and vascular function in association with metabolic disturbances in rats. Additionally, resveratrol was tested at challenge with HFCS. We investigated the effects of HFCS (10% and 20%) and resveratrol (50mg/l) beverages on several metabolic parameters as well as endothelial relaxation, vascular contractions, expressions of endothelial nitric oxide synthase (eNOS), sirtuin 1 (SIRT1), gp91(phox) and p22(phox) proteins and superoxide generation in the aortas. Consumption of HFCS (20%) increased serum triglyceride, VLDL and insulin levels as well as blood pressure. Impaired relaxation to acetylcholine and intensified contractions to phenylephrine and angiotensin II were associated with decreased eNOS and SIRT1 whereas increased gp91(phox) and p22(phox) proteins, along with provoked superoxide production in the aortas from HFCS-treated rats.Resveratrol supplementation efficiently restored HFCS-induced deteriorations. Thus, intake of HFCS leads to vascular dysfunction by decreasing vasoprotective factors and provoking oxidative stress in association with metabolic disturbances. Resveratrol has a protective potential against the harmful consequences of HFCS consumption.

    Copyright © 2012. Published by Elsevier Ltd.

    PMID: 22465803

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