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  • The natural antidote to high-fructose corn syrup (this doesn’t mean you can consume this sugar without consequences though)

    September 23, 2014: by ResveratrolNews

    European Journal Nutrition 2014 Sep 11. [Epub ahead of print]

    High-fructose corn syrup-induced hepatic dysfunction in rats: improving effect of resveratrol.



    The increased consumption of high-fructose corn syrup (HFCS) may contribute to the worldwide epidemic of fatty liver. In this study, we have investigated whether HFCS intake (20 % beverages) influences lipid synthesis and accumulation in conjunction with insulin receptor substrate-1/2 (IRS-1; IRS-2), endothelial nitric oxide synthase (eNOS), sirtuin 1 (SIRT1) and inducible NOS (iNOS) gene expressions in liver of rats. Resveratrol was tested for its potential efficacy on changes induced by HFCS.


    Animals were randomly divided into four groups as control, resveratrol, HFCS and resveratrol plus HFCS (resveratrol + HFCS). HFCS was given as 20 % solutions in drinking water. Feeding of all rats was maintained by a standard diet that enriched with or without resveratrol for 12 weeks.


    Dietary HFCS increased triglyceride content and caused mild microvesicular steatosis in association with up-regulation of fatty acid synthase and sterol regulatory element binding protein (SREBP)-1c in liver of rats. Moreover, HFCS feeding impaired hepatic expression levels of IRS-1, eNOS and SIRT1 mRNA/proteins, but did not change iNOS level. Resveratrol promoted IRS, eNOS and SIRT1 genes, whereas suppressed SREBP-1c expression in rats fed with high fructose corn syrup.


    Resveratrol supplementation considerably restored hepatic (liver) changes induced by high fructose corn syrup. The improvement of hepatic insulin signaling and activation of SIRT1 gene by resveratrol may be associated with decreased triglyceride content and expression levels of the lipogenic genes of the liver.

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