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  • Is A 150-Year Lifespan Just Around The Corner?

    February 20, 2018: by Bill Sardi

    From the land down under, Australians are becoming acclimated to an idea brought to a present reality by one of their own – geneticist David Sinclair at Harvard Medical School. Dr. Sinclair says to reporters with the Financial Review that: “Living To 150 Will Revolutionize Markets” as if it is a development that is just around the corner. Imagine the profound financial let alone human implications of a 150-year lifespan.

    Dr. Sinclair says within our lifetimes it is likely humans may creep in small increments towards commonly living beyond 100 years.

    Christopher Joye, who writes for The Financial Review, says his projections show the population of Australia doubling as advancements that add years to the end of life continue to unfold and be put into practice. Dr. Sinclair says humanity can even expect 10-20 year jumps in life expectancy. Actual reversal of biological aging has already been demonstrated in the animal lab, adds Sinclair. As evidence, when tested, Sinclair’s biological age is 31 years in his 51-year old body.

    Reporter Christopher Joye says: “While Sinclair says immortality is a long way off,” he also says “there is no biological or physical law that says we cannot live for thousands of years.” “It is feasible but it is like asking the Wright brothers whether we will one day land on the moon. I hope he’s right!”

    So Why Has Resveratrol Struck Out As An Anti-Aging Pill?

    It was David Sinclair who first connected the scientific dots between a red wine molecule (resveratrol), activation of a longevity gene (Sirtuin1) and the French Paradox – the French have the most centenarians of any population on a per capita basis and defy the fact they eat higher calorie/higher fat calorie meals that is apparently negated by their consumption of red wine.

    But when resveratrol was tested in the animal lab it struck out. It did extend the life of animals fed a high-fat diet but not animals fed a standard calorie diet.

    Now we find researchers may have been over-dosing the laboratory animals with resveratrol.

    Researchers at the University of Wisconsin maintain the method of dosing resveratrol was based on body weight. A dose of 22.4 milligrams per kilogram (2.2 lbs.) of body weight was used. Calculated for a 60-kilogram (132-lb.) adult human that would amount to 1344 milligrams per day. One would have to drink 672 bottles of red wine to accomplish that. Researchers made it appear the promise of a long life was beyond reach.

    The University of Wisconsin researchers say resveratrol dose should be calculated by body surface area rather than by weight. Using that equation, a 109-milligram dose would be appropriate, which can be easily accomplished with dietary supplements.

    “The news media reports distort the dose translation between the study of mice and the human equivalent dose. Low-dose resveratrol (100 mg Longevinex®) was proven to achieve a greater biological effect than mega-dose resveratrol, particularly when that brand of resveratrol pills is combined with other synergistic molecules.

    Designer niacin another misdirection?

    Resveratrol works by increasing NAD (Nicotinamide adenine dinucleotide), an electron-transfer agent and anti-aging agent. Over a decade ago the public was told that resveratrol mimics the health benefits posited by a lifespan-doubling calorie-restricted diet and that niacin, which is ubiquitous in food, shuts off the Sirtuin1 gene.

    But now we find that niacin is a precursor for NAD and that better niacin molecules (nicotinamide riboside, nicotinamide mononucleotide) are now being promoted. A recent report extolling supplementation with nicotinamide riboside to head off Alzheimer’s disease did mention that nicotinamide (niacinamide) provided in common multivitamins does the same thing. But that fact got lost in the scientific jargon.

    Right now no one knows if niacinamide, the non-flush niacin provided in multivitamins, is equivalent to these designer NAD boosters. Resveratrol is said to be superior to niacin in activating NAD. ###

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