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  • A Diet To Go Along With Resveratrol Pills

    April 12, 2015: by Bill Sardi

    Recently this author has underscored the importance of sugar restriction in the control of cancer. [] Newly published science provides further insight into the importance of low-carbohydrate (bread, rice, pasta) and low-sugar diets to improve cancer survival. A new finding is how a restricted sugar/carbohydrate diet enables anti-cancer molecules such as resveratrol to exert their anti-cancer properties.

    Investigators wondered if a low-carbohydrate diet combined with molecules that genetically mimic a limited calorie diet would improve cancer survival rates.

    The researchers combined four polyphenols, resveratrol (known as a red wine molecule), quercetin (from red apple peel), curcumin (from turmeric spice) and EGCG (green tea extract), and provided them to laboratory animals that were placed on a low-carbohydrate diet. The results were startling.

    Supplementation of these four herbal extracts did not increase survival in rodents who had been injected with cancer (melanoma) cells.

    A low-carbohydrate or modest carbohydrate diet also did not improve survival. However, the low-carbohydrate diet combined with the four herbal extracts improved survival time from 23 to 28 days (~20% greater survival).

    The low-carbohydrate diet + herbal extracts suppressed IGF-1 (insulin growth factor-1) and TOR (target of rapamycin) genes and activated AMPK and Sirtuin-1 survival genes. The widely acclaimed Sirtuin-1 survival gene suppressed tumor growth and prolonged survival only in a low-glucose (low sugar) condition.

    A modestly reduced calorie diet also did not prolong survival, which suggests a tightly regulated diet is required. Another finding is that a combination of herbal extracts produces more powerful effects at lower doses.

    Comparison: survival

    Development of liver tumors and survival in laboratory animals on three different diets

    In another part of the experiment laboratory animals were placed a normal calorie diet (group 1), a lowered-calorie diet (group 2) and a lower calorie diet + herbal extracts (group 3, as shown above). [European Journal Cancer Prevention March 19, 2015]


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