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  • The Absurdities Of Marketing Resveratrol

    October 1, 2010: by Bill Sardi

    “Resveratrol this and resveratrol that, it cures most everything in the laboratory rat.”

    Main points:

    • What do you get when shopping for resveratrol pills at Wal-Mart and Costco?
    • Will your resveratrol pill switch your genes in time to achieve superlongevity?
    • Can resveratrol be molecularly altered to improve its performance and bioavailability?
    • Can you overdose on resveratrol?
    • Is Sirtuin1 gene activation the end-all way of evaluating the effectiveness of resveratrol pills?
    • Which is the best-tested brand of resveratrol pills?

    Resveratrol — the red wine molecule heralded for its potential to reverse biological time, to erase the ravages of human aging, to do what only could be previously imagined in science-fiction books.  But the rush to commercialize resveratrol is trivializing its future.  A cobweb of false advertising, pseudoscience (even in published scientific journals), misleading labeling and potential side effects posed by overdosing could provoke regulatory agencies to step in and declare this molecule a drug, robbing the public of direct access to this miracle of our time.

    Resveratrol is now an additive in chewing gum, beer, nutrition bars, various and sundry beverages, and of course, myriads of dietary supplements.

    If you can imagine the absurdity of thinking that you will be adding a few minutes to your lifespan for every stick of resveratrol gum you chew, you will begin to realize how this miracle molecule is being trivialized with pseudo-science and promoted by companies who simply have rushed to commercialize resveratrol before its health benefits are proven.  The next thing you know, resveratrol will be added to table salt and sprinkled on popcorn.

    Generally speaking, resveratrol is for the over-40 crowd.  It is an antidote to aging.  It has anti-growth properties that are not appropriate to growing children, pregnant women and those who are anemic.

    Placing resveratrol in food bars and chewing gum in doses beyond the few micrograms provided by grapes and peanuts in the general diet, that growing kids might pick up at eat, is simply irresponsible.  But one of the largest suppliers of raw materials for nutriceuticals is leading the charge to place resveratrol in foods and beverages.  Resveratrol is fast becoming a pop-science ingredient that is being brandished as a cure-all.  Yes, certainly, it may be, but among which segment of the population and at what dosage?

    It is said that resveratrol, as a small molecule, mimics a calorie restricted diet.  But is it a glutton’s delight? “Can you have your cake and eat it too?!” Can we eat as much as we like and not pay the price by downing a resveratrol pill?  Well, not quite yet.

    A limited calorie diet, which resveratrol is theorized to mimic, does avert age-related weight gain in animals. However, the only experiment which showed resveratrol produces leanness had to force-feed the human equivalent of 14,000 milligrams of resveratrol (that would be fourteen 1-gram pills a day) down the throats of laboratory mice. Any online shopper can quickly find makers of resveratrol who make bogus claims their red wine pills produces weight loss.  As in most cases of false advertising, there is a little bit of distorted truth mixed with real fact.

    So will any old resveratrol pill do?

    Like flour dough in bread, resveratrol is fast becoming a commodity.  Yet there are a lot of bread bakers, but only a few who make truly nutritious whole-grain bread (despite the misleading labels).

    The verifiable health claims for resveratrol cannot be transferred to every product that contains resveratrol because of failure to provide the research-grade resveratrol used in laboratory experiments, and failure to employ the precise human equivalent dose used in animal or human clinical trials.  Furthermore, the labeled dose may not be what is provided in the product.

    When Longevinex® confronted the industry about this problem it was immediately burdened with two lawsuits from resveratrol pill makers who didn’t want this fact disclosed.  Hundreds of thousands of dollars in legal fees later a revelation was made outside of courts of law.

    ConsumerLab® conducted tests and found two major competitors that were engaged in litigation against Longevinex®, had far less resveratrol in their pills than their label indicated.

    This is what the dietary supplement industry does to hush up its embarrassing and even fraudulent mistakes – burden a competitor with legal fees as they hold onto their existing business.

    Mega doses and diminishing returns

    Many brands of resveratrol brag they provide the highest amount of resveratrol for the price, but with diminishing health benefits and increased risk for side effects as the dosage rises.

    Dipak Das PhD, a heart researcher at the University of Connecticut, has found the optimal human dosage range for resveratrol in the heart is less than 175 milligrams for a 160-lb (70 kilogram) adult.  At 350 mg resveratrol begins to lose its protective effect in the heart.  A 1750 mg dose of resveratrol actually worsens damage to heart muscle tissue in the event of a heart attack.  In one experiment as little as 365 mg slightly shortened the lifespan of laboratory animals.  Yet there are 500-mg and 1000-mg resveratrol pills recklessly being sold in retail stores today, accompanied by boastful advertising which mistakenly assumes more is better.  Some resveratrol pill users may be putting their lives on the line by following the bad advice from novices who produce resveratrol pills.

    Molecular combinations

    There is now voluminous data to show that the combination of resveratrol with other small molecules magnifies its biological and genomic effect far beyond an additive effect.  Plain resveratrol pills miss the mark by a mile.

    Red wine produces profound health benefits while delivering small amounts of resveratrol (3-5 milligrams in 3-5 glasses) accompanied by an array of other molecules such as quercetin, catechin, ferulic acid, etc.

    Plain resveratrol pills should mimic red wine in composition, as best as possible, in order to replicate the French Paradox, the fact that French wine drinkers have the similar circulating cholesterol levels as North Americans but exhibit a coronary artery disease mortality rates that is 2.7 times lower (90 per 100,000 versus 240 per 100,000).  Controlled studies confirm resveratrol is far more powerful when combined with other small molecules.

    The accompanying ingredients and the recipe for making resveratrol pills make the difference among the estimated 290 brands now being offered online and at retail outlets.

    The French have found a way to remain lean despite a high-calorie, high-fat diet, and to produce an unprecedented number of centenarians — 20,000 of them living to 100 years or more.  It’s the highest ratio of centenarians per capita among all the countries of the world.

    But the health benefits of French red wine are not produced solely by resveratrol.  It is an array of small molecules delivered in an alcohol base that produces red wine’s magical effects.  The combined biological power of low doses of these wine solids produces a more profound effect than the highest dose of pure resveratrol alone. This fact got lost in all the hype about resveratrol.  The whole is greater than its parts.  The recipe of ingredients in a resveratrol pill yields greater health benefits than plain resveratrol.

    This is not to say there are no health benefits from downing modest doses of a plain resveratrol pill every morning.  The potential health benefits of plain resveratrol produced in the laboratory are more than striking, and include prevention of sudden-death heart attack, blockage of all cancer mechanisms, improved mood, reduced inflammation, better bone and muscle strength, elevated immunity, to name a few.  But even these health benefits are largely achieved with lower rather than higher doses.  In fact, low doses of resveratrol more aptly mimic the effects of a low-calorie diet.  However, the optimal health benefits promised by resveratrol are only achieved when other molecules are combined with it.

    One study showed when 100 milligrams of resveratrol was combined with other small molecules (Longevinex®), such as those found in red wine, the genomic effect was 9-fold greater.  In a short-term study, Longevinex activated 1711 longevity genes in laboratory mice compared to just 225 genes for plain resveratrol.  Furthermore, life-long calorie restriction, which is the unequivocal practice that nearly doubles the lifespan of all living organisms, activates about 832 genes. It would likely require many decades of resveratrol pill consumption to activate that many genes and truly mimic a limited calorie diet.  But Longevinex® more than doubled the number of activated genes in just a short time.

    If this rodent study can be extrapolated to humans (mice have a similar number and sequence of genes as humans), resveratrol pill users may be wasting their time and money and many are likely to die before they experience the full benefits of this molecule.

    Price shopping to a fault

    Certainly, consumers like to shop around for the best price.  However, comparison shopping can work against many consumers because it is so difficult to compare one product against another.

    For example, the cost of ingredients and microencapsulation in one product, Longevinex®, which is the best-tested brand, and was the first to provide 100 mg of stabilized trans resveratrol in a base of other red wine molecules, exceeds the retail price of many brands of resveratrol supplements now on the market.  For example, one low-priced brand selling at COSTCO for $7.99 (with coupon) provides just 1 milligram of resveratrol.  You have to down 100 of their tablets to get 100 mg.

    Or how about resveratrol offered at Wal-Mart, but resveratrol is only advertised on the front label and the Supplement Facts box doesn’t even list resveratrol as an ingredient!

    (Take that, old man who keeps calling this author to say he can purchase the equivalent of Longevinex® at Wal-Mark for $7.00 a bottle!)

    Again, compare Longevinex® to a product sold at COSTCO that says it provides 100 mg of trans resveratrol, but when you read the label carefully, to get that amount you have to consume 5 caplets a day!  The same company that sells these pills previously sold a liquid resveratrol product at COSTCO that was so unstable it was admittedly fermenting into vinegar in the bottle!

    Yet Longevinex® (~$27/month supply) is not the high-price leader ($74.99/month supply) by a wide margin.  While that $74.99 product offers 500 mg of resveratrol, but that is a mega-dose that was found to shorten the lifespan of laboratory mice.

    Or how about a commercially available resveratrol pill that touts it also provides calcium, which actually accelerates human aging and runs counter to the anti-aging properties of a red wine pill!  Unfortunately, many resveratrol pills today are formulated by fast-buck artists.

    Is there a superior type of resveratrol molecule?

    Then there are a bevy of resveratrol products that claim their resveratrol molecule is superior to others.

    Regardless of how resveratrol is presented – stabilized, micronized, sublingual, organic, or methoxylated as pterostilbene, as it is in many dietary supplements, its molecular formula is still C14H12O3. So will any old resveratrol pill do?  Well, again, that depends upon whether you want the optimal health benefits produced by resveratrol, without any drawbacks posed by over-dosage.

    Dr. Dipak Das recently showed in animal studies that high-dose resveratrol is “cytotoxic,” that is, it kills healthy living cells.  At 3500 mg human equivalent dose resveratrol “kills the mouse heart every time,” says Dr. Das.

    Longevinex® is about to unleash a published study showing its proprietary resveratrol pill exhibits no cytotoxicity whatsoever up to 7000-mg human equivalent dose in two species of animals (rodents and rabbits).  This is a world’s first!  An L-shaped risk curve is what biologists call it.  Wine and resveratrol produce a U-shaped or J-shaped risk curve – at modest doses risk for mortality declines but at mega-doses mortal risk rises above that of non-users. The underlying protective mechanism is being kept as a trade secret for now.

    Advertising that purports organic resveratrol as being purer is almost laughable.  Pesticides are not used to grow Giant Knotweed (Polygonum cuspidatum, botanical name), the source of most botanically-extracted resveratrol.

    Ditto for sublingual (under the tongue) resveratrol — stomach acid does not degrade resveratrol.  Being a small molecule, it is immediately absorbed in the gut.

    About 70% of orally-consumed resveratrol is absorbed in humans.  Micronization (reduction in particle size) may enhance absorption by another 15%, but this is no magnanimous advantage either.  About 115-mg of plain resveratrol would deliver about the same amount of this molecule as 100-mg of micronized resveratrol.  (There is one guy who ridiculously claims his brand of micronized resveratrol is 500% better absorbed.  Just how do you increase absorption by 500% when plain resveratrol is 70% absorbed?  The best you can do is increase absorption by another 30%.)

    What makers of resveratrol pills ought to be working on is stabilizing resveratrol to make it as close as possible to research-grade product that is sealed in airtight vials and stored at -20° Fahrenheit, since analysis shows some degradation from trans to cis resveratrol in unprotected products.

    Exposure to UV radiation degrades resveratrol from its biologically active form (trans resveratrol) to its degraded and less biologically-active form (cis resveratrol).  Exposure to heat also degrades resveratrol.  Its inclusion in processed foods may require special stabilization methods.

    Microencapsulated resveratrol (enfolded in plant starches and dextrins) retains the molecular integrity of resveratrol even when it has been exposed to direct rooftop midday sunlight at an Arizona testing laboratory.  (Data on file, Longevinex®. )  Furthermore, Longevinex® dry powder is placed in an opaque capsule to block all incoming light.  Then it is foil packaged.  This is as close to research-grade resveratrol as one can get.

    The claim of superior bioavailability made by purveyors of pterostilbene – a methylated form of resveratrol, is particularly annoying.  Despite some widespread scientific confusion about the bioavailability of resveratrol, plain resveratrol is biologically available.  It produces system-wide health benefits in remote parts of the human body including the brain and kidneys.

    It is true that resveratrol is temporarily made unavailable by virtue of it being attached to detoxification molecules in the liver which make it too large a molecule to pass through cell walls and penetrate the blood-brain barrier.  However, this is advantageous as it prolongs the half-life (degradation rate) of resveratrol from a few minutes to many hours.

    Most of the resveratrol that circulates in the blood is conjugated (attached) to detoxification molecules (glucuronate, sulfate) in the liver, since resveratrol is perceived as a potential toxin by the body.  This is what turns on all the body’s defenses and produces the many health benefits attributed to resveratrol.

    So how does resveratrol get un-tethered from these detox molecules so it can pass through cells walls and the blood brain barrier?

    Nature has its own resveratrol delivery system.  An unzipping enzyme called glucuronidase is abundantly produced at sites of inflammation, infection and malignancy.  This frees resveratrol from its carrier molecule and delivers what is called “free” unbound resveratrol at the right time and place.

    The claim by any entity that they have invented a more bioavailable form of resveratrol is patently false.

    About Sirtuin gene activation

    Yes, early on, Longevinex® was suckered into claiming its product activated the Sirtuin1 longevity gene after tests conducted at a biotech laboratory were conducted.  However, quite embarrassingly, it was found the initial study published in 2003 in Nature Magazine, which claimed resveratrol is the best molecular activator of Sirtuin1 (Sir2 in yeast cells), was flawed.  A fluorescent dye used in the test activated the Sirtuin1 gene, not resveratrol.

    Then later researchers at MIT reported that the Sirtuin1 gene is not activated in all tissues and organs in calorie restricted animals.  So Sirtuin gene activation cannot be used as a reliable measure of calorie restriction, which is the gold-standard against which all resveratrol longevity pills must be measured.  So Longevinex® no longer mentions Sirtuin1 in its advertising.

    Aging involves hundreds of genes, not a single gene.  Makers of resveratrol pills that continue to refer to Sirtuin1 gene activation ignorantly do so without understanding this science has been discredited.  (So much for consumers who call up and ask if Longevinex® activates the Sirtuin1 gene?  They have fallen for mistaken science.) Most makers of resveratrol haven’t a clue that the scientific understanding of resveratrol’s gene targets has changed.

    Proven science

    Currently, the best-tested resveratrol pill is Longevinex®.  It presents a summary of its published science for all to view and evaluate below.

    May other brands make impermissible claims their resveratrol products produce weight loss, eradicate wrinkles, grow hair, restore lost memory and even cure cancer, using bloggers who receive kickbacks as front men, and borrowing from existing medical literature under the false assumption their products work as well as those in the laboratory, even though their products often don’t provide resveratrol in the same dose used in controlled studies.

    Here is the current list of published scientific investigation involving Longevinex®.  For those savvy consumers who demand human data, be aware that some studies, such as those where animals must be sacrificed for analysis of tissue, are simply impossible or impractical to reproduce in humans.

    PUBLISHED STUDIES INVOLVING LONGEVINEX®

    • Superior activation of longevity genes in heart and brain tissue at an earlier point in time than plain resveratrol, as demonstrated by Affymetrix gene array in rodents.*  [Experimental Gerontology 2008]
    • Proven cardio-protection in animals at one capsule (100 mg resveratrol) per day.  Would theoretically work better than aspirin.  [In press, Canadian Journal Physiology & Pharmacology, 2010]
    • Proven ability to eradicate cellular debris (autophagy) from aging cells (rodent study).  [In press, Journal of Cellular and Molecular Medicine, 2010]
    • Absolute lack of cytotoxicity (death of healthy cells) at mega-doses, in rodents.* L-shaped risk curve.  [In press, Experimental & Clinical Cardiology, 2010]
    • Proven cholesterol reduction and improved circulation in animals. [In press, Molecular & Cellular Chemistry, 2010]
    • Profound and unprecedented genomic effect as demonstrated by microRNA testing.  Unprecedented inhibition of angiogenesis (new blood vessel formation), which may have application in the eyes, kidneys and in abnormally-growing cells.* [Manuscript submitted]
    • Rapid activation of sluggish white blood cells and inhibited stickiness of blood platelets, in humans.*  [Data on file, Nutriscreen laboratory, 2009]
    • Reduction of markers of inflammation and oxidation in endurance athletes. [Independent study, Appalachian State University, 2007]
    • Reduced insulin, reduce markers of inflammation, improved dilatation (widening) of blood vessels (first sign of atherosclerosis) among overweight humans with elevated blood sugar.*  [Japanese Circulation Society 2011 Annual Meeting]

    *First time shown in biology

    © 2010 Bill Sardi, Resveratrol Partners LLC, dba LONGEVINEX®

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13 Responses to “The Absurdities Of Marketing Resveratrol”

  1. Dr. Michael Powers Says:
    October 2nd, 2010 at 6:45 am

    Greetings,

    Thank you for the information. As is true with all of your articles, it’s wonderfully comprehensive. I have three questions about Longevinex, which perhaps you could answer.

    (1) Is there any reason to believe that consuming a capsule of
    longevinex with a glass of red wine would enhance its positive
    action?

    (2) Red onions are among the richest sources of quercetin. Would having
    red onions, along with a longevinex capsule, perhaps amplify the
    positive action of the Longevinex?

    (3) Setting aside speculation, has Longevinex actually increased the
    maximum life span of laboratory mice?

    Keep up the good work.
    Best wishes,
    Michael

    ResveratrolNews.com

    (1) There is! There is no way to duplicate what wine delivers in regard to its array of molecules (resveratrol, quercetin, catechin, malvidin, kaempferol, gallic acid, ferulic acid, etc) So a glass of dark red wine would theoretically provide additive and synergistic action to Longevinex. Also, you can’t replace the relaxation and romance that wine offers with a pill. Good red wine also helps digest a meal.

    (2) A red onion provides ~25 mg of quercetin. Would likely be helfpul.

    (3) this is the carrot all so-called anti-aging pills keep chasing. There are reports now, just being published in late 2010 which give a thumbs down on plain resveratrol as a life-prolonging molecule. One of the confounding problems is that resveratrol does profoundly improve health, but appears to slightly shorten lifespan. However, most of these studies have been high-dose studies and my take on this is that high-doses induce anemia, weakens the immune response and results in earlier mortality. This has been seen with anti-inflammatory drugs (VIOXX) and with mega-dose resveratrol. The resveratrol-treated animals succumb to lymphoma. Another recent revelation by cancer biologists is that tumors spread in the lymph system, not in the arterial or venous system. This makes better sense since the lymph is the garbage end of the circulatory system. What comes to mind here is that a person taking high-dose resveratrol pills might be fooled by their improved health, but not achieve the desired longevity. I keep pointing biologists to the real world, not the laboratory, and the French who drink 3-5 glasses of dark polyphenol-rich red wine, and they live far longer and healthier than other human populations. Now that the French are backing away from tobacco, the red wine effect is really taking hold in France. For a relatively small population, France has more than 20,000 confirmed centenarians. The problem with attempting to prove that Longevinex prolongs life in a laboratory animals is that test takes about 3-4 years and would cost a few million dollars. I continue to maintain that blindly conducting experiments without a hypothesis is folly. What theory of aging are the biologists attempting to measure? I maintain there is only one explanation for the three speeds of human aging (youth- no measurable biological aging; full-growth – progressive aging; maturity – slowed rate of aging), which is overmineralization. There are markers for mineralization. These need to be employed in all longevity studies. For example, in Japan, Longevinex was put to the test in a study of patients with metabolic disease (diabetes, obesity). Longevinex failed to produce weight loss, but the iron storage number (ferritin) did not decline. This showed that a larger dose would have likely produced the desired result. We know that animals that exhibit negligible aging, like turtles and the naked mole rat, produce offspring throughout life and therefore donate calcium and iron and copper to their babies, thus limiting accumulation of these minerals. The idea of a pill doing this is what Longevinex is about. Fortunately, short of conducting longevity studies, we have some biological markers of aging that can be used, such as lipofuscin accumulation, labile iron, and red blood cell width, which may give us a quicker measure of the proposed life-prolonging effects of Longevinex. Longevinex has already been shown to remove lipofuscin from the human retina. There will be much more to share about this soon. -Bill Sardi

  2. Hal Bryman Says:
    October 2nd, 2010 at 7:46 am

    I am currently taking Longevinex Advantage. How is it different from the original Longevinex? Why have two different versions of Longevinex? I am almost 82 years old. Which version do you recommend and why?

    ResveratrolNews.com:

    Longevinex Advantage is a pocketbook issue. Astounding reports have been received of its benefits. Longevinex has not conducted a study yet as to how many benefit out of 100 users. Consumers are a bit confused by so-called anti-aging pills because, in their mind, they want to look younger, not just live longer. That is what Longevinex Advantage is designed to do. Some users report “facial rejuvenation,” a younger appearance to the point where others notice. It works by activating fibroblasts, cells that make hyaluronan, a gooey, gel-like, water-holding molecule in the skin, hair, eyes and joints. -Bill Sardi

    Please also see:

    http://www.longevinexadvantage.com/longevinexcomparison.html

  3. Nancy Mason Says:
    October 2nd, 2010 at 11:50 am

    Based on Dr. Stanley Monteith and Dr. Russell Blaylock’s recommendation, I bought Longevenix over a year ago. After a couple weeks, I started getting heart palpitations and dizziness and had to stop taking it. When I stopped, I was back to normal after a couple days. Why did it affect me this way? It did not affect my husband like this. I am a 61 yr. old woman who weighs 110 lbs at 5’5″ and am in good health. I eat a very healthy diet and take several supplements recommended by Dr. Blaylock’s newsletter.

    Thanks for your response.

    ResveratrolNews.com:

    Yes, it is likely that you were becoming a bit anemic. The heart then has to pump faster to deliver the same amount of oxygenated blood, and you experience this as heart palpitations. Also, upon awakening, the heart may beat a bit faster as Longevinex dilates (widens) blood vessels to control blood pressure, and this effect may induce a temporary fast heart beat (nitric oxide effect). I advise consumers who experience this problem to take Longevinex less often. -Bill Sardi

  4. Mike Fowler Says:
    October 2nd, 2010 at 12:47 pm

    Bill,

    Very thought provoking article. Was disappointed that “a summary of its published science for all to view and evaluate below.” contained no links to the cited research or even the abstracts thereof.

    If you want the reader to evaluate the research, why make it difficult to do so?

    Sincerely,
    Mike Fowler
    Chicago

    ResveratrolNews.com:

    thank you for the suggestion. We will do this for you soon. A mountain of new studies is soon to be published and then we will create links to the reports. -Bill Sardi

  5. Marjorie Trafeli Says:
    October 2nd, 2010 at 1:38 pm

    I am wondering why I just paid almost $70 for a one month supply of Longevinex, not the $27.00 you are citing in your article. Yes, it provides 60 pills but suggests two pills to be taken a day. So I am disappointed that you are not stating the truth about your product’s price comparison to other products on the market.

    ResveratrolNews.com:

    Longevinex Advantage is a higher-priced product and has expensive ingredients. If purchased 3 boxes at a time, a free box is included, and the effective price is ~$47 a box. Longevinex Advantage is designed to address aging of connective tissue, which results in visible signs of aging (skin wrinkles, thinning hair, shrinking eyes, creaky joints). This product has been a god-send for many, but we try not to over-promote it. The regular Longevinex should not be over-shadowed by Advantage, which is also more affordable. Understand, most other resveratrol pills cost no more than $3-4 a bottle to make. Longevinex costs many times more to make. For the cost-conscious, Advantage users can try 1-capsule a day and see if it works for them. Longevinex Advantage addresses the consumer who wants to appear younger, not just live longer. -Bill Sardi

  6. Bruce Guyette Says:
    October 2nd, 2010 at 2:16 pm

    Bill……a well written article. I was a Longevinex customer, but, for a short time, switched to another product brand of resveratrol for the cost savings and a higher dosage. I stopped taking resveratrol altogether based on conflicting claims of effectiveness. I plan to start taking Longevinex’s resveratrol again soon. Thanks again for the insightful article.

    Best regards,
    Bruce Guyette

  7. Cheryl and Dan Evenich Says:
    October 2nd, 2010 at 11:07 pm

    My husband has CLL Leukemia and his doctor recommended he take Longivenix for red blood cell regeneration. His last two blood tests have improved and his hair has grown back thick and curley…even partially on his bald spot. This doctor is Asian and is very saddened by using chemotherapy as it can have harsh side effects. He is leaving that up to husband as to whether he wants chemo but at this time, he has improved a bit.

    Is Longevenix appropriate for an individual with an enlarged abdomen, massive capilliary defects on legs, thinning hair and age spots.

    Thanks

    ResveratrolNews.com:

    Without prescribing, yes. Chemotherapy is somewhat helpful in cases of non-solid tumors such as leukemia (cancer of the blood), but cannot penetrate solid tumors. It is very toxic, particularly to the heart, and cancer patients often succumb to heart failure caused by chemo before they expire from their disease. Inexplicably, oncologists often advise patients to avoid antioxidants during chemotherapy because they oppose the toxic treatment. This is nonsense. Antioxidants protect against the side effects of treatment. I can only say that there is a man in his 80′s, retired genetics professor, in Hawaii, who has survived end-stage leukemia for a number of years now. He began taking Longevinex and no longer needed blood transfusions. He resumed driving. His blood count improved, he regained his lost side vision, and stopped having fainting spells. Not one oncologist has been bold enough to launch a small pilot study to see if resveratrol pills will help with leukemia. We are talking compassionate use here, since modern medicine has no effective therapy for leukemia. -Bill Sardi

  8. David Newell Says:
    October 3rd, 2010 at 12:48 am

    The discourse appears to have credibility beyond any other that I have read. I’m not an expert, but have a highly sensitive BS meter that has not been simulated at all. I’ve one bias: I believed it (the research and benefits assertions) 2 years ago, also, and bought a case of Longevinux for a not insignificant sum at the time.

    3rd party testimonies such as this are not all that credible (placebo effect, desiring to demonstrate that it was intelligent to have made the investment..) etc..

    And I’ve no way to check into the universe in which I did not take the Longevinex to see how I’m doing without it..

    But even at that, I will assert my opinion that it is well worth it, and should be seriously considered for acquisition, if you are “age-appropriate”, as I surely am.(66), {and almost 1/10th the devil.. “:<) }

    ResveratrolNews.com:

    It might be interesting for readers here to know that the so-called placebo effect was conjured up to demean dietary supplements. There is no evidence for a placebo effect of any sort. Placebo effect is just another part of the pseudoscience of western medicine. There is something called a conditioned response where a person sees an artificial flower and starts to sneeze. But placebo effect is not backed by science, as well accepted as it is. Researchers in Germany analyzed studies involving placebo and found that taking nothing always matched placebo. You might want to read my critique of the placebo effect here: http://www.chiro.org/nutrition/FULL/Debunking_the_Placebo.shtml As for testiminials, they do not apply to all. But they do point in a direction. They are instructive to design studies to determine how many out of 100 might obtain the same benefit. The problem here is that, for example, in the case of the 80-year old woman who took Longevinex and was no longer bedridden, it is unlikely we will be able to ever put a study together to test that. In her case, she didn’t even know she was taking Longevinex because it was added to her liquid multivitamin without her knowledge. We avoid dotting the Longevinex website with insulting testimonials that cannot be confirmed. – Bill Sardi

  9. Terry Says:
    October 3rd, 2010 at 2:43 am

    The most convincing account of the properties and benefits of resveratrol I have read to date. A very interesting read and one that doesnt wreak of prevaricated spin. Thanks for the info, cheers.

    ResveratrolNews.com

    I made a personal pledge to all those people who took Longevinex on my word, that I would be as candid as possible about any information, positive or negative, about resveratrol. It certainly has been a confusing area of investigation, with so many misconceptions, even by researchers themselves. Dosage and bioavailability are key issues. I hope we get to the bottom of all this soon. I think everyone really wants to know the answer to the question: is this really an anti-aging pill? If so, history will be in the making. -Bill Sardi

  10. morris shamah Says:
    October 3rd, 2010 at 4:34 am

    could u comment on Thorne’s new Resveretrol SR-that combines a form of curcumin(Meriva)

    ResveratrolNews.com:

    curcumin is another polyphenolic small molecule found in turmeric spice. Research reports continue to consistently show that combinations of the small molecules, when provided in low doses, work far better than any single nutrient in high dose. Longevinex chose to add ferulic acid rather than curcumin to its formula, first because two molecules of ferulic acid “holding hands” = curcumin. The smaller ferulic acid molecule is likely to be more effective. Second, ferulic acid is naturally found in red wine. Third, ferulic acid comes from a purer source (rice bran) than curcumin. -Bill Sardi

  11. Franklin Sherman Says:
    October 3rd, 2010 at 6:06 pm

    I am a regular user of Longevinex Advantage. Thanks for this valuable article. Question: you say that glucuronidase is active at sites of malignancy, inflammation, and infection. But presumably, as a rather healthy, aging-well person I will have any of these only rarely. What about the in-between times?

    ResveratrolNews.com:

    yes, good question. First, Longevinex includes quercetin which delays glucuronidation and sulfation in the liver, allowing more passes through the liver before resveratrol is fully metabolized (conjugated with glucuronate or sulfate). This means quercetin allows for more instant bioavailability of resveratrol. Second, low-grade inflammation produces glucuronidase. Believe me, if you are a middle-aged adult, your middle-section is a hotbed for inflammation, which is why humans tend to develop a bulging waistline with advancing age. Biologists call this inflammaging. The same is occurring in the brain. Ditto for the prostate. These are the critical areas where inflammation is rampant and where resveratrol is biologically active. -Bill Sardi

  12. Carol Rae Says:
    October 5th, 2010 at 1:44 pm

    Thanks Bill for your informative article. I need to reoder soon. I have been directing friends to the Longevinex site and hopefully they are ordering too. My budget is strapped to the max now, but hope to have that corrected soon and get back on Longevenix. Carol Rae

  13. Joe Matejka Says:
    September 7th, 2013 at 8:25 am

    Bill Sardi, are you a medical doctor? What are your qualifications?

    ResveratrolNews.com:

    I have written about 12 health books you can find at http://www.naturalhealthlibrarian.com

    (proceeds all go to the webmaster)

    I went to school and took journalism.

    I have no qualifications except the references I cite, which are usually voluminous.

    If my penned words are not worth reading, readers are welcome to dismiss what I say and look elsewhere.

    Obviously they have, ResveratrolNews has only a few devotees who value what is said there.

    We are fighting a losing battle against western medicine. We could realize a world almost without heart attacks and far less cancer and diabetes, but that is not going to happen. It is not the efficacy or lack of efficacy of a red wine pill that will hold up progress, but rather the fact the public listens to doctors, wants someone with a diploma on their wall, like you are obviously searching for. Let me tell you, they aren’t going to put themselves out of business. The world is currently being gamed. Prevention is not in play. They have to have disease to keep their jobs. I hope you catch on and don’t pay the price for buying into everything modern medicine dishes out.

    You can read other articles I have written about health at http://www.knowledgeofhealth.com (non-commercial website; no subscription fees; no commercial use of your email address)

    Bill Sardi

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