Comprehensive Library Of Resveratrol News

Fisetin, naturally abundant in strawberries, is a newly recognized entry in a field of anti-aging molecules that are widely studied but underutilized in modern medicine.  A recent study shows consumers with the highest dietary consumption of strawberries have a much lower risk for brain aging.  Researchers show that strawberry supplementation reduces risk factors for heart disease, including blood pressure, inflammation, and total cholesterol.

Once single-gene targeted synthetic drugs failed to become the “holy grail” for youth-promising drugs, natural molecules like resveratrol, quercetin, catechin, have been difficult to improve upon.   These small molecules are advantageous because they can pass through cell walls to influence genetic machinery.  They pass through blood/brain and blood/ocular barriers.  And they target many, many genes, more when combined to achieve synergistic effects.

A recent animal study published in the Journal of Gerontology: Biological Sciences (Vol 73, 2017) reveals the response of fisetin among laboratory mice genetically bred to become “senescent.”  This genetic strain of mice exhibits progressive age-related decline in brain function like humans do.  They develop early deterioration of learning and memory as well as systemic inflammation, accumulation of beta amyloid brain plaque, and premature mortality.  These test mice had fisetin added to their diet for 7 months.  The results were striking.

These fisetin-fed mice:

• Were better able to navigate mazes and escape from physical threats.
• Were better able to deal with changing circumstances
• Exhibited behavior more characteristic of younger animals.
• Exhibited better locomotion (controlled movement)
• Were better able to recognize objects
• Retained proteins in brain cells responsible for transfer of signals across synapses (gaps between brain cells), believed to be a primary problem among humans who have Alzheimer’s disease.
• Surprisingly and unexpectedly, fisetin increased levels of docosahexaenoic acid (DHA), an omega-3 molecule critical for brain function.
• Arc protein, a marker of memory, was maintained in old fisetin-fed animals.
• Fisetin resulted in a young “phenotype” (shaped by its environment, not its inherited genetics).

Another animal study noted fisetin’s anti-inflammatory properties that resulted in an antidepressant effect.

Fisetin has been demonstrated to reverse senescence (aging) in old macrophages (mack-row-faj-ez), a type of white blood cell that literally engulfs and digests circulating pathogenic bacteria and tumor cells.

Limiting calorie intake to one meal a day has been shown to double the healthspan and lifespan of laboratory animals.  Researchers have shown that fisetin, the least-studied molecular mimic of a calorie-restricted diet, increases internal antioxidant activity and is a bona-fide anti-aging molecule.

Longevinex® is the first longevity nutraceutical to add fisetin to its formula that includes the red wine molecule resveratrol, and quercetin, another small polyphenolic molecule found naturally in red apple peel and onions.  Longevinex® was also first to stabilize resveratrol; first (and only) resveratrol pill to undergo toxicity testing (required by FDA); first resveratrol pill to undergo micro-RNA testing; first to demonstrate molecular synergism (activated 9-fold more longevity genes that plain resveratrol in global gene array study); first to micronize and microencapsulate resveratrol; first to demonstrate resveratrol crosses the blood/ocular barrier; first to add beta cyclodextrin as a solubilizing agent; first to add nucleotides (DNA spare parts) to its formula to accelerate DNA repair; first (and only agent in biology) to exhibit an L-shaped toxicity curve (no toxicity even at high-dose) compared to plain resveratrol (U-shaped risk- curve) that promotes oxidation in mega-doses; first to demonstrate in humans the ability to reverse prolonged time for the eyes to adapt to darkness, a marker of retinal aging.