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  • Dietary Supplement Users Shortchanged When Resveratrol Not Accompanied By Other Polyphenols

    February 26, 2018: by Bill Sardi

    A recent report published in the journal Biomolecules and Therapeutics reveals the unparalleled ability of two natural molecules to address symptoms caused by diabetes.

    Two natural molecules, quercetin and resveratrol, when used together are being extolled for their synergistic ability to quell the metabolic problems posed by diabetes and the drugs used to treat the disease.  Undesirable side effects that accompany most anti-diabetic drugs (weight gain, low-blood sugar and death of insulin-making cells in the pancreas) as well as complications in other organs (kidneys and liver) prompt researchers to search for less problematic alternatives.

    Indeed, quercetin, a natural molecule commonly found in red apple peel, onions and wine, and resveratrol, concentrated in wine, exhibit ability to promote the regeneration of pancreatic islet cells that produce insulin in experimental animal studies.

    The combination of quercetin and resveratrol reduced hemoglobin A1c scores (a measure of long-term blood sugar control) and increased insulin secretion better than either molecule alone.  Furthermore measures of liver and kidney function were best normalized by the two molecules.  In fact, the fasting blood glucose (sugar) levels of quercetin + resveratrol-treated animals was close to normal.  These two molecules also switched on protective internal antioxidant enzymes (glutathione, superoxide dismutase), something anti-diabetic drugs fail to do.  Researchers conclude quercetin + resveratrol are a “useful strategy for the treatment of diabetes.”

    Another study published in the journal Cardiovascular Diabetology points to the ability of quercetin + resveratrol in exhibiting Viagra-like effects in diabetic animals.

    At concentrations equivalent to that found in red wine, resveratrol and quercetin inhibited cell growth of tumors says a report published in the journal Anticancer Drugs.

    Over 30 years ago resveratrol and quercetin were identified as molecules that inhibit both types of blood clots (thrombin and blood platelet clumping), therefore inhibiting heart attacks caused by blockages in coronary arteries says a report published in the International Journal of Clinical Chemistry.

    Recently the ability of quercetin and resveratrol to favorably alter gut bacteria (intestinal bacteria) and therefore inhibit obesity has been documented in the journal Food & Function.

    The synergistic (more than additive) biological action of molecules like quercetin, resveratrol and catechin (commonly found in green tea) have been well documented in the medical literature.  According to a report in the Journal of Cellular Biochemistry these three natural molecules comprise more than 70% of the protective molecules in red wine.  Yea, these same three molecules as described in a report published in the journal Translational Oncology, even at the very lowest concentration, strongly inhibit tumor cell growth in tumors implanted in laboratory animals.  ©2018 Bill Sardi,


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