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  • Resveratrol Does The Impossible

    November 8, 2017: by Bill Sardi

    Nov. 7, 2017:  The hope of a fountain of youth has been dashed forever.  It was just days ago (October 30th) that researchers at the University of Arizona who study human aging said that it is mathematically impossible to halt or reverse the biological clock hands of time.  Gone is the prospect of living young instead of growing old.  The idea of an anti-aging pill is a pipe dream – like trying to catch the wind.  It is biologically unattainable.

    There is logically, theoretically, mathematically no way out,” said a professor of evolutionary biology.  Aging is inevitable.

    • Over time hair cells cease making pigment and hair turns grey.
    • Mitochondria, the tiny power plants within living cells gradually lose their ability to generate energy.  By age 80 only about 4% of these cellular power plants are functional.  Instead of cells largely generating energy from fats they generate energy from sugars that can then cause uncontrolled growths (cancer).
    • As old cells begin to become senescent, that is, they cannot divide and renew themselves as easily as they once did.

    Aging is “an incontrovertible truth” a university-based biologist recently said.  “You might be able to slow down aging, but you can’t stop it” said another professor of evolutionary biology.  An authoritative report published in the Proceedings of the National Academy of Sciences says, once and for all, aging is inescapable.

    Scientific U-turn

    Wait!  Stop the biological clock.  Some 5,267 miles away, researchers at the University of Exeter, England, report the impossible.  The evidence is clearly visible – old cells in lab dishes rejuvenate and become youthful again over a 92-hour period!  Some cells regained youthful activity within just 17.5 hours!  Within a short time these “youthified” cells had remarkably longer telomeres, the ends caps of their chromosomes.  What, pray tell, provoked such a rapid biological U-turn?

    Cells: Untreated vs Resveratrol

    Row A: untreated cells  Row B: resveratrol-treated cells

    Researchers report: “We found that cells treated with resveratrol or resveratrol-like molecules had telomeres that were 1.3–2.4 times longer than untreated cells.”

    One researcher said: “This is a first step in trying to make people live normal lifespans, but with health for their entire life. Our data suggests that using chemicals to switch back on the major class of genes that are switched off as we age might provide a means to restore function to old cells.”

    What researchers discovered is that splicing factors within aged cells that cause cells to divide and regenerate can be turned back on again with instillation of resveratrol and its analogs (look-alike molecules).

    Resveratrol is known as a red wine molecule that activates the Sirtuin1 survival gene, mimics the health effects of a limited calorie diet, renews mitochondria, and more importantly, raises the prospect of living youthfully throughout life.

    The lead researcher who conducted these experiments at was quoted to say:
    “It was like magic.  When I saw some of the cells in the culture dish rejuvenating I couldn’t believe it.”

    By restoration of splicing factors, old cells are able to grow and perform the self-healing observed in youthful cells.  The landmark experiment is documented in a recent edition of BMC Cell Biology in a report entitled Small Molecule Modulation Of Splicing Factor Expression With Rescue From Cellular Senescence.

    In the researchers own words: “Here, we provide evidence that treatment with the… compound resveratrol is associated not only with restoration of splicing factor expression but also with amelioration of multiple cellular senescence phenotypes in senescent human primary fibroblasts.”

    Unlike other lab-dish experiments that show only impractically high and even potentially toxic doses of resveratrol would be needed, this time researchers report “Remarkably… very low doses of the resveratrol and its analogues led to significant increases (up to 0.6 population doublings) in total cell numbers over only 24 h of drug exposure.”

    While these researchers pointed to the synthetically produced resveratrol analogues, it appears resveratrol itself was on par with its synthetic cousins.

    Here is a graphic depiction of resveratrol and five other resveratrol molecules used in the study.  The first molecule show (#1) is resveratrol, the others (2-6) are analogs:

    Molecule: Resveratrol and Analogs

    Here is a graph excerpted from the published study showing how well each molecule activated the Sirtuin1 survival gene:

    Chart: Sirt1 Activation

    Bar #1 is resveratrol.  What this means is that prolonged youthfulness, or even reversal of aging as we know it, can be accomplished at the cellular level with a molecule that is widely sold in health shops today, no synthetic molecules needed.  Biologically, you would never be too old to benefit from taking a resveratrol pill.

    Among 530 commercially available brands of resveratrol pills, only one (Longevinex®) has been tested for dosage, toxicity, ability to activate genes, effectiveness in crossing the blood barriers in the eyes and brain, and ability to renew mitochondria.  – ©2017 Bill Sardi, ResveratrolNews.com

     

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