NEWS

RECENT DISCOVERY:
Resveratrol reduces both the mortality and
the liver damage associated with alcohol abuse.

Effect of resveratrol on alcohol induced mortality and liver lesions in mice. ABSTRACT OBJECTIVE: Resveratrol is a poly- phenol with important anti inflammatory and antioxidant properties. We investigated the effect of resveratrol on alcohol induced mortality and liver lesions in mice. DESIGN: Mice were randomly distributed into four groups (control, resveratrol-treated control, alcohol and resveratrol-treated alcohol). METHODS: Chronic alcohol intoxication was induced by progressively administering alcohol in drinking water up to 40% v/v. The mice administered resveratrol received 10 mg/l in drinking water. The animals had free access to standard diet. Blood levels were determined for transaminases and IL-1. A histological evaluation was made of liver damage, and survival among the animals was recorded. RESULTS: Transaminase concentration (liver enzyme) was significantly higher in the alcohol group than in the rest of groups (p<0.05). IL-1 levels were significantly reduced in the alcohol plus resveratrol group compared with the alcohol group (p<0.05).

Histologically, the liver lesions were more severe in the alcohol group, though no significant differences between groups were observed. Mortality in the alcohol group was 78% in the seventh week, versus 22% in the alcohol plus resveratrol group (p<0.001). All mice in the alcohol group died before the ninth week.  At the 8th week 100% of alcohol-treated mice had died versus 50% of alcohol+ resveratrol-treated animals.

CONCLUSIONS: Resveratrol reduces the mortality and liver damage associated with alcohol abuse. Bujanda L, Garcia-Barcina M, Gutierrez-de Juan V, Vidaurazaga J, Fernandez de Luco M, Gutierrez-Stampa M, Larzabal M,  Hijona E, Sarasqueta C, Echenique-Elizondo M, Arenas JI.

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