THE MANY BIOLOGICAL ACTIONS OF RESVERATROL

A work in progress

Biological action

Reference

Preserves or stimulates superoxide dismutase (antioxidant)

J Agriculture Food Chemistry 2005 May 18; 53(10):4182-6; Free Radical Biology Medicine 2003 Apr 1; 34(7):810-7

Elevates glutathione (antioxidant)

 

J Agric Food Chem. 2005 May 18; 53 (10):4182-6; Archives Biochemistry Biophysics 2000 Sep 15; 381 (2):253-63

Elevates catalase activity (antioxidant)

Life Science 2003 May 2; 72 (24):2741-50

Prolongs life of cells via Sirtuin 1 gene

 

Trends Pharmacological Sciences 2005; 26:94-103

Anti-histamine action (allergy)

 

Planta Medica 2004 Apr;70(4):305-9,

 

Anti-inflammatory agent

 

J Chemotherapy 2004 Nov;16 SuppI 4:3-6;

J Environ Pathology Toxicology Oncology 2004; 23(3):215-26

COX-2 inhibitor (anti-inflammatory)

 

Inflammation Research 2005 Apr; 54(4):158-62

Potentially helpful for rheumatoid arthritis

International Immunopharmacology 2005 May;5(5):849-56

Inhibits pancreatitis

 

World J Gastroenterology 11: 3171-74,2005

Promotes DNA repair (via Sirtuin 1 gene)

 

Nature 2003 Sep 11; 425 (6954):191-6

Inhibits abnormal new blood vessel formation (angiogenesis)

J Physiology Pharmacology 2005 Mar;56 Supp11:51-69

Inhibits dietary sugar absorption

 

Journal Natural Products 2001; 64:381-84

 

Regulates blood sugar

 

J Agric Food Chemistry 2005 May 4; 53(9):3403-7

Normalizes blood pressure

 

J Hypertension 2000 Dec; 18(12): 1833-40

 

ACE Inhibitor properties

 

European J Pharmacology 2005 May 16; 515(1-3): 1-9

Prevents blood clots

 

Blood Coagulation Fibrinolysis 2004 Sep;15(6):441-6

Reduces LDL cholesterol

 

Life Sciences 2003 Aug 1; 73(11):1393-400

 

Reduces triglycerides

 

Life Sciences 2003 Aug 1; 73(11): 1393-400

 

Raises HDL "good" cholesterol

 

J Agric Food Chemistry 2005 May 4; 53(9):3403-7

 

Biological action

Reference

Inhibits arterial plaque w/o altering

cholesterol

IntJMol Med. 2005 Oct;16(4):533-40.

 

Calms effects of estrogen (estrogen

blocker)

J Steroid Biochemical Mol Biology 2005 Apr;94(5):431-43

Prevents bone loss

 

J Medicinal Food 2005 Spring;8(1):14-9

 

Protects retinal cells (retinal pigment

epithelium)

 

Chemical Biological Interaction 2005 Jan 15; 151(2): 143-9

 

Increases sperm count

J Nutrition 2005 Apr; 135(4) :757-60

Inhibits viral growth (influenza)

 

J Infectious Disease 2005 May 15; 191 (10): 1719-29

Inhibits viral growth (HIV)

J Pharm Science 2004 Oct; 93 (10):2448-57

Inhibits viral growth (herpes)

 

Antiviral Research 2004 Jan;61(1);19-26; 1999  Oct;43(3): 145-55

Antibiotic against bacteria (Chlamydia)

 

Atherosclerosis 2003 Dec;171(2):379-80

 

Antibiotic against bacteria (H. pylori)

 

Am J Gastroenterology 2003 Jun;98(6):1440-1

 

Inhibits growth of fungi (yeast, mold)

 

J Agriculture Food Chemistry 2003 Feb 26:51 (5): 1464-8

Inhibits initiation of tumors

 

Proc NatI Sci Counc Repub China B. 1999 Jul;23(3):99-

106

 

Inhibits growth of tumors 2

 

Drugs Experimental Clinical Research 1999:25(2-3):65-77

Inhibits spread of tumors 3

Proc NatI Sci Council Repub China B. 1999 Jul;23(3):99-106

Targets multiple genes (silencing/activation)

I J Nutritional Biochemistry. 2005Aug;16(8):449-66

Protects brain cells__________

 

Ann N Y Academy Sciences 2003 May;993:276-86

Inhibits hepatitis (liver inflammation)____

 

I Hepatogastroenterology 2002 Jul-Aug;49(46):1102-8

Eradicates plaque in brain (beta amyloid

toxicity)

British J Pharmacology 2004 Mar;141 (6):997-1005

Chelates metals (copper)_________

 

Biochem Pharmacology 1997 May 9; 53(9): 1347-55

Anti-leukemia agent__________

 

iLeukemia Lymphoma 2002 May;43(5):983-7

   

Inhibits prostate cancer

 

Cancer Epidemiology Biomarkers Prevention 2005 Mar;14(3):596-604

Inhibits breast cancer

Molecular Nutrition Food Research 2005 May;49(5):462-71

Inhibits melanoma

I Neoplasia2005Jan;7(1):37-47

Inhibits liver cancer

World J Gastroenterology 2003 Oct;9(10):2341-3

Inhibits brain cancer

[Molecular Cancer Therapy 2005 Apr;4(4):554-61

Inhibits pancreatic cancer

Pancreas 2002 Nov;25(4):e71-6

 

Inhibits kidney cancer

Cancer Biology Therapy 2004 Sep; 3(9):882-8

Inhibits colon cancer

International J Cancer. 2005 Jun 10; 15(2): 194-201

Inhibits ovarian and cervical cancer

Anticancer Res. 2004 Sep-ct;24(5A):2783-840.

Inhibits lymphoma

Cancer Letters 2001 Feb 10,163(1 ):43-9

Exhibits Viagra-like effects (nitric oxide)

 

Free Radical Biology Med. 2004 Mar 15;36(6):774-81

Novel molecule for organ transplants

World J Gastroenterology. 2005 Aug 14;11(30):4745-9

 

Non-toxic

J Nutrition 2002 Feb;132(2):257-60

 

 

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