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Effects of Injection of Resveratrol | |||
| No response – | Partial response – some measurable shrinkage in tumor size | Total regression of tumor – undetectable with naked eye |
Control group – | 5 of 5 | 0 of 5 | 0 of 5 |
Resveratrol-treated mice | 0 of 5 | 2 of 5 | 3 of 5 |
An experiment was conducted by Swedish researchers to explore the effects of resveratrol on tumor growth in hairless mice carrying tumors who were treated daily with 25 milligrams/per kilogram (2.2 lbs) of resveratrol for 3 weeks. This is the human equivalent of 1750 milligrams of trans-resveratrol for a 160-pound human. Weekly measurement of tumor size revealed a significant inhibition of tumor growth in the resveratrol-treated group. After 3 weeks, tumors in the untreated group were approximately five times larger than their size at start of treatment, while resveratrol-treated tumors showed a decrease in size between resveratrol-treated mice and controls at weeks 2 and 3. The median tumor size in the resveratrol-treated group at week 3 was 4 mm3 compared to 182 mm3 in the control group. As shown below, all five tumors in the control group increased in size, while three of the five tumors in the resveratrol-treated group decreased to such an extent that they were no longer detectable. Resveratrol-treated mice showed no weight loss or other signs of systemic toxicity compared to controls.
Reference: Cancer Letters Volume 231, Issue No. 1, 8 January 2006, Pages 113-122.
Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo
Stina Garvin, Karin Öllinger and Charlotta Dabrosin, 
aDivision of Gynecologic Oncology, Faculty of Health Sciences, University Hospital, SE-581 85 Linköping, Sweden
bDivision of Pathology II, Faculty of Health Sciences, University Hospital, SE-581 85 Linköping, Sweden
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