MORE ARTICLE
PREVIEWS

 NEWS
Date: Saturday June 25

RESVERATROL EXHIBITS PROFOUND
EFFECTS ON PROSTATE CANCER CELLS

Stanford, CA - Stanford University School of Medicine researchers report profound anti-prostate cancer properties for resveratrol, a small antioxidant molecule found in grapes, red wine and other botanical sources.  The Stanford Researchers employed gene expression, cell cycle and prostate specific protein analysis.  As evidenced by the chart below, resveratrol, in concentrations achievable in humans, inhibited prostate cancer cell growth by 16% at 24 hours and 83% by 60 hours after instillation of purified resveratrol into cell dishes. 

 Time course of resveratrol-induced inhibition of prostate cancer cell growth compared to cells treated with DMSO. 

Stanford researchers said “Dramatic gene expression changes accompany this cell cycle arrest and are distributed throughout all phases of the cell cycle.”

PSA (prostate specific antigen), a well-characterized male sex hormone-regulated gene, was also repressed by greater than 2-fold 12 hours after treatment with resveratrol.  (See chart below)

The Stanford researchers go on to say that “animal and human studies have shown that resveratrol is rapidly absorbed in the gut, attaining highest concentration in the blood in 1 hour,” and that desirable changes in gene expression were obtained with concentrations of resveratrol attainable in rodents, “however, the levels of resveratrol used in this study that result in gene expression modulation in vitro may or may not be attainable in man. At the very least, the relatively low concentration of resveratrol in grapes or wine will likely make it necessary for it to be given as a dietary supplement.”

Reference: Cancer Epidemiology Biomarkers & Prevention Vol. 14, 596-604, March 2005

Resveratrol-Induced Gene Expression Profiles in Human Prostate Cancer Cells

Sunita B. Jones¹, Samuel E. DePrimo¹, Michael L. Whitfield² and James D. Brooks¹ Departments of ¹ Urology and ² Genetics, Stanford University School of Medicine, Stanford, California

=end= 

BACK TO ARTICLE PREVIEWS
Articles, papers, arguments & opinions, thoughts, all welcome.
Email to: admin@resveratrolnews.com
Our FORUM operates 24/7  ...  LIVE.

MORE ARTICLE
PREVIEWS