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How the world got lost on
the road to an anti-aging pill
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July 7, 2015: by Bill Sardi
A recent study published in the Annals of Internal Medicine notes the accumulation of calcium in arteries predicts mortality. An adult with a calcium arterial score 1000 as determined by a CT scan will face a 626% increased risk of premature death compared to an adult with a calcium arterial score of 0-10. Overall 15-year mortality rates ranged from 3% to 28% for calcium arterial scores from 0 to 1000 or greater. [Annals Internal Medicine July 7, 2015]
July 5, 2015: by Bill Sardi
This writer has already reported that the prospect of an anti-aging pill gaining official approval by the Food & Drug Administration has inched closer to reality with the submission of a proposal for a 5-7-year study involving 3000 subjects 70-80 years of age. The study would cost $50 million but funding has not yet been approved. [Nature June 17, 2015]
If the study is approved by the FDA and funded by the National Institutes of Health somewhere around the year 2020-2022 the world would hear whether Metformin, already an FDA-approved anti-diabetic drug, serves to slow or even reverse aging and the become the world’s first approved anti-aging pill. From existing published literature it can be said with a some degree of certainty the answer will be yes.
June 27, 2015: by Bill Sardi
American consumers are reticent to begin using resveratrol dietary supplements because they are unfamiliar with it. Sales of other herbal products such as garlic and curcumin from turmeric spice used for a variety of ailments, milk thistle for liver disease, Echinacea for the common cold and saw palmetto for prostate enlargement soar over resveratrol, which isn’t even in the top 100 selling herbal products.
Many consumers feel they need permission from their doctor to use resveratrol while they have no hesitation to use the above-mentioned herbs even though resveratrol has not been reported to produce serious side effects since it was widely publicized over a decade ago.
The shame is that modern medicine will not put resveratrol to the test in controlled human studies. The very scientific impetus behind resveratrol was as a red wine molecule that may be responsible for the French paradox as described by French physician Serge Renaud in the early 1990s. The French paradox is the fact the wine-drinking French eat fatty foods and have higher blood cholesterol levels but far lower mortality rates for coronary artery disease. [Novartis Foundation Symposium 1998]
June 22, 2015: by Bill Sardi
Ten years ago the Rand Corporation think-tank penciled in anti-aging pills into future Medicare budgets. That prognostication has been forgotten. Covert opposition to anti-aging pills, in particular resveratrol, has been the order of the day for the past decade. Various spin doctors have misled the public on this miraculous red wine molecule over the past decade. [ResveratrolNews.com Dec 29, 2014; LewRockwell.com Nov 13, 2006]
Promising studies built up hopes of such a pill but those hopes were then dashed by specious studies that over-dosed lab animals thus negating resveratrol’s beneficial effects or misinterpreted data, such as the more recent wine study conducted in Italy. That study didn’t even use resveratrol pills but mistakenly concluded resveratrol didn’t reduce mortality rates among adults living in the Tuscany region of Italy but failed to note heavy tobacco use negated any life-prolonging benefits of wine and overlooked that wine nearly halved the rate of mental decline. [ResveratrolNews.com May 12, 2014]
June 8, 2015: by Bill Sardi
Despite an archive of over 73,000 research papers published in the last two decades on the subject of Alzheimer’s disease, little clinical progress has been made relative to how people can avoid this devastating brain disease. [Biofactors March-April 2012]
Alzheimer’s memory loss is a dreaded mental condition. Surprisingly, only 5% of cases of Alzheimer’s are related to family history and 95% of cases present with sporadic symptoms whose origins are likely dietary and environmental. [Molecular Neurobiology Dec 2013] For example, refined sugar intake is consistently associated with mental impairment. [Current Opinion Clinical Nutrition Metabolic Care July 2013]
May 9, 2015: by Bill Sardi
Question: Should resveratrol users also add niacin-like pills to their dietary supplement regimen?
Answer: A decade ago David Sinclair PhD at Harvard Medical School announced the red wine molecule resveratrol molecularly mimicked a life-and-health prolonging calorie restricted diet. Humans would not need to deprive themselves of food to double their healthspan and lifespan as demonstrated in the animal laboratory.
The opposite biological signal of food deprivation is provided by niacin (vitamin B3) since it is ubiquitous in foods. So should niacin be avoided when taking resveratrol pills? We don’t want to send two biological signals at the same time do we?
The biological answer to that question gets a bit complicated.
May 4, 2015: by Bill Sardi
You didn’t read the above headline in any news reports this week.
Four years ago researchers in Japan reported that the red wine molecule resveratrol maintains and even reverses mutations in a key gene (Werner Syndrome Gene or WRN gene) that is involved in maintenance and repair of DNA and telomeres, the end caps of chromosomes. [Current Aging Science Feb 2011]
Also, another study published nearly 7 years ago found that resveratrol activates the Sirtuin1 survival gene and stabilizes bundles of human genes, the same gene bundles called chromatin that researchers now link with human aging. [Cancer Cell Oct 7, 2008]
April 16, 2015: by Bill Sardi
Researchers announce in the Journal of Neuroscience that the use of a small synthetic molecule drug (difluoromethylornithine or DFMO) improves memory in laboratory mice by virtue of its ability to inhibit arginase, an enzyme that degrades the amino acid arginine. [MedicalXpress]
In 2009 researchers began to explore the role that a shortage of the amino acid arginine plays in the development of Alzheimer’s disease. Arginine plays many roles in the body, enhancing immunity, controlling insulin activity and reducing inflammation, but arginine is largely known as the precursor for nitric oxide gas, a dilator (widener) of blood vessels.
April 12, 2015: by Bill Sardi
I wrote on this topic just a little over a month ago, but the pace of change in the anti-aging field is so fast that it seems like a decade ago. [ResveratrolNews.com Feb 15, 2015]
The focus of my report last month was more about breakthrough developments and commercialized products now available that address what would be considered the greatest challenge that mankind has ever faced – the quest to conquer mortality.
: by Bill Sardi
Recently this author has underscored the importance of sugar restriction in the control of cancer. [KnowledgeofHealth.com] Newly published science provides further insight into the importance of low-carbohydrate (bread, rice, pasta) and low-sugar diets to improve cancer survival. A new finding is how a restricted sugar/carbohydrate diet enables anti-cancer molecules such as resveratrol to exert their anti-cancer properties.
Investigators wondered if a low-carbohydrate diet combined with molecules that genetically mimic a limited calorie diet would improve cancer survival rates.