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How the world got lost on
the road to an anti-aging pill
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March 29, 2016: by Bill Sardi
According to a compilation of recently published science the red wine molecule resveratrol (res-vair-ah-trol) is poised to open an era of regenerative medicine that could profoundly add many years to the healthspan and lifespan of Americans.
Why? Because, as researchers recently pointed out, any technology that delays the age-related decline in the human immune system could result in a generation of senior Americans who live 120 healthy years or more. [Ebiomedicine 2016]
While American medicine has stumbled around for the past decade or two debating how to do this [Immunology Reviews 2005], resveratrol has now been found to counter virtually all of the genetic pathways that lead to the age-related decline in the human immune system, a fate that affects virtually all senior adults over age 60 and results in otherwise avoidable cases of pneumonia and cancer as well as chronic inflammation and autoimmune disorders.
March 12, 2016: by Bill Sardi
Resveratrol pills are posed as a molecular mimic of a limited calorie diet. Short of a ten-decades long study it may be difficult to produce conclusive evidence that resveratrol pills promote the same lifespan-healthspan doubling effect of a calorie-restricted diet in laboratory animals. Such a study would be impractical as well as exceedingly expensive.
Longevity seekers must rely upon animal studies or markers of human aging to measure whether an intervention like daily resveratrol (rez-vair-ah-trol) consumption would be worthwhile
Will resveratrol pills significantly extend the healthspan and lifespan of humans? There may now be a partial answer to that question, though it takes reading some round-about science.
February 6, 2016: by Bill Sardi
Strikingly, researchers report that life-long administration of a modest dose of the red wine molecule resveratrol (rez-vair-ah-trol) given to laboratory mice keeps their visual system intact and retains their retinal sensitivity to light via activation of the Sirtuin1 survival gene. [Biochemical & Biophysical Research Communications 2015]
With advancing age the retinas of humans and animals lose sensitivity as measured by the electrical response of retinal cells (rods and cones) to light stimulation. But when these animals are given life-long (19 months, equivalent to ~65 years in a human) oral doses of resveratrol, their retinal sensitivity approximates a youthful state.
January 21, 2016: by Bill Sardi
In 2009 I wrote about resveratrol theoretically replacing marijuana because this red wine molecule targets the same cell receptor site (endocannabinoid receptor) as marijuana and its chief molecule cannabis or more specifically tetrahydrocannabinol. [ResveratrolNews.com]
When I wrote that report over six years ago there was not all the public interest in cannabis as there is today with legalization in some US States. So this topic is worthy of a scientific update.
As an update, a recent report compares the ability of resveratrol to target the cannabinoid cell surface receptor as amitriptyline (Elavil), a popular antidepressant and nerve pain medication. [Psychopharmacology Jan 20, 2016]
January 19, 2016: by Bill Sardi
Cardiac researchers writing in the International Journal of Vitamin Nutrition Research report the combination of low-doses of the red wine molecule resveratrol plus vitamin D results in profound prevention of heart muscle damage following an experimentally induced heart attack in animals.
The area of scarring (fibrosis) of heart muscle tissue was reduced from 41.3% in untreated animals to 30.1% (28% reduction) in resveratrol-treated animals and an astounding 17.6% in animal treated with low-dose resveratrol + vitamin D (57% reduction!). This report is groundbreaking and unprecedented. It could signal a new era in preventive heart care far above what a daily aspirin tablet offers.
January 11, 2016: by Bill Sardi
The ineffectiveness and side effects of flu vaccines has resulted in lack of public demand for flu shots. Today, less than half of Americans believe flu shots will help them avoid illness and a third don’t believe they will protect them at all. [Harris Poll, WebMD Dec 15, 2015] The ineffectiveness of the flu vaccine has been well documented. [Knowledge of Health]
Outside of vaccines, a limited number of antiviral drugs are available and the problem of drug resistance looms. The widely used drug Tamiflu has been declared ineffective. [BBC News April 10, 2014]
January 7, 2016: by Bill Sardi
With recognition that microorganisms that reside in the human digestive tract act as the body’s “second brain,” that the 100-million nerve cells in the gut carry information from the digestive tract to the brain and not the other way around to influence behavior and mood is a recent scientific revelation. [Scientific American 2010; CNS Neurological Disorders Drug Targets 2014]
This new scientific understanding is referred to as the “gut-brain axis” is now recognized as a regulator of mood, cognition (thinking), pain, mood, sleep and eating behavior. [Advances Applied Microbiology 2015]
Microbes that are out of balance in the digestive tract (a condition called dysbiosis where there are too few beneficial bacteria and an overgrowth of bad bacteria such as yeast/Candida and parasites) are not only involved in metabolic disorders (i.e. obesity) but also in emotional behavior.
December 28, 2015: by Bill Sardi
While it will be said that resveratrol is an unproven (but not disproven) pain reliever, it may be a safer and more effective reliever from the agony of chronic pain than existing pain remedies, both prescription and non-prescription.
Recently research discovered why some people are less sensitive to pain than others. A master pain switch has been discovered. Pain is controlled by a cellular sodium channel which permit pain signals to pass along nerve cell membranes. People born without a functioning sodium channel called Nav1.7 do not feel pain. Without this sodium channel, low levels of internal opioids (natural narcotics) are naturally produced. Sodium channel-blocking drugs are used as local anesthetics but are unfortunately unsuitable for long-term pain relief as they induce complete numbness. [Nature Communications 2015]
December 21, 2015: by Bill Sardi
What a year in anti-aging research and anti-aging pill offerings. An article in The Daily Beast called it “The Year We Decided To Live Forever,” referring to the billionaires (Peter Thiel, Breakout Labs; Larry Ellison, Oracle CEO; Paul Glenn, anti-aging philanthropist; Larry Page, Google co-founder, Calico; Craig Venter, Human Longevity) who have dedicated hundreds of millions of dollars in the pursuit of biological immortality. [Daily Beast Dec 4, 2015]
Researchers say the world may finally get an anti-aging pill, but it will be on their terms. Somebody has to pay back the millions of dollars being invested in developmental drugs for what has been called “the greatest problem of our time” – aging.
December 15, 2015: by Bill Sardi
Given the assumption humanity is not going to deprive itself of food to live an extra 40-50 healthy years (healthspan and lifespan doubles among calorie restricted animals), biological short cuts in the form of molecular mimics of calorie restriction appear more practical. Widespread use of properly dosed small molecules could achieve super-longevity only rivaled by the Biblical patriarchs.
Mild biological stress activates cellular defenses. Small molecules, as presented here, that can pass through cell walls and enter the nucleus and favorably influence genetic machinery are abundant in nature. Cells with a mass of less tan 100 nanometers (billion of a meter) in one direction can absorb molecules and pass through the blood/ brain barrier. [Nanomedicine 2011] Many natural molecules already are smaller than 100 nanometers and don’t require nanosizing to enter cells. [Knowledge of Health]