test your knowledge
How the world got lost on
the road to an anti-aging pill
Subscribe to our newsletter to receive email notifications when new articles are posted.
December 27, 2016: by Bill Sardi
December 16, 2016: by Bill Sardi
The first images of laboratory mice reprogrammed to reverse aging are presented above. [Cell Dec 15, 2016] Laboratory mice genetically altered to age prematurely show signs of age reversal upon epigenetic reprogramming. The mouse on the right (-Dox) exhibits a curved spine characteristic of a premature aging syndrome called progeria in humans. The reprogrammed mouse on the left (+Dox) exhibits a more youthful thicker coat and absence of the abnormal spine curvature. Internal organs were also more youthful in reprogrammed mice. Animals were genetically altered to produce a premature aging syndrome akin to progeria, which results in shortened lifespan (~13 years in humans) with premature baldness, cataracts and skin wrinkling in youth. While progeria is caused by a mutation in a single gene (LMNA, pronounced lamin-A) researchers were able to reverse aging changes in these animals by alteration of protein-making (i.e. epigenetics) in just four genes (known as Yamanaka factors). Mice and humans house a similar library of genes (~25,000) in the nucleus of their cells. The age-reversal effects were accomplished by returning cells back to their original embryonic state in order to remove certain epigenetic marks that occur in aging without altering the abnormal sequence of DNA (gene mutations) responsible for premature aging itself. This suggests biological fate can be changed.
December 14, 2016: by Bill Sardi
Researchers report the administration of resveratrol to newborn rodents whose brains were experimentally deprived of oxygen after birth reduced tissue damage 7-days after the event and protected the newborn brain. [Oncotarget Nov 2, 2016]
Researchers say: “The immature brain is unable to repair itself from this injury; however, resveratrol may preserve the structure and morphology (physical makeup) of injured tissues and prevent dysfunction in the affected brain cells (neurons)” even 7-days after the event.
December 11, 2016: by Bill Sardi
Modern medicine is getting into the soothsayer business. Various technologies now make it possible to foresee the health future of an individual and predict with some certainty which maladies may befall a person years before symptoms or signs become apparent.
December 5, 2016: by Bill Sardi
Blood plasma exchange from old to young, modified versions of calorie restriction and a third new approach to super-longevity have emerged in the past year. Humans now have instruction how to achieve an indefinitely long lifespan.
Short of having surgeons intertwine your organs and blood vessels with another younger individual in an intervention called parabiosis that was previously shown to improve health and prolong life of laboratory animals, researchers recently infused blood plasma from young adult humans into to old mice which resulted in a similar dramatic rejuvenation of the body and brain. New cells were created in the hippocampus, the thinking lobe of the brain. Researchers describe young blood plasma as having a “massive rejuvenating effect.” [Daily Mail Nov 15, 2016]
November 16, 2016: by Bill Sardi
The study was compelling. Bacteria samples were taken from twins, one lean the other overweight, and implanted into the gut of healthy mice. The results were astounding. Mice that received gut bacteria from the lean twin remained healthy and lean while the mice that received bacteria from the overweight twin piled on a massive amount of weight. [Science Sept 6, 2013]
November 2, 2016: by Bill Sardi
Two-thousand years ago Roman soldiers wrapped their wounds in wine-soaked bandages and chewed garlic going into battle as an antibiotic. From that point forward we can’t say modern pharmacology has advanced much beyond that point.
The broad biological action of the molecules in grapes and garlic cloves activate key genes (mTOR, AMPK, NF Kappa B, Sirtuin1, Sirtuin3, Foxo1 and Nrf2) that perform beyond the limited capacity of any synthetically made molecule. [Resveratrol News Dec 15, 2015]
October 17, 2016: by Bill Sardi
There is an old joke about the miracle of the Thermos bottle, which one salesman called the greatest invention in the world.
A by-stander asked why a Thermos bottle would be considered the greatest invention in the world.
“It keeps hot food and beverages hot and cold food and beverages cold” the salesman said.
The by-stander had the gumption to ask: “But how do it know?” [ButHowDoItKnow.com]
Similarly resveratrol exhibits inexplicable divergent biological activity to the puzzlement of biologists.
October 6, 2016: by Bill Sardi
While more and more adults are living actively into their 8th decade of life and beyond, improvements in survival with advancing age tends to decline after age 100 years. [Nature Oct 5, 2016] Researchers who study aging now say humanity may have reached the outer limits of longevity as the no modern human has lived beyond the age of 122 years, the apparent maximum lifespan. [Daily Mail UK Oct 5, 2016; New York Times Oct 5, 2016]
The Bible says: “Then the LORD said, “My Spirit shall not strive with man forever, because he also is flesh; nevertheless his days shall be one hundred and twenty years.” [Book of Genesis 6:3] So maybe today’s news headlines are not new at all.
Read the whole post »
September 8, 2016: by Bill Sardi
Activation of the Sirtuin1 survival gene has been extolled for its epigenetic mimicry of a lifespan-doubling calorie-restricted diet. In 2003 Harvard-based geneticist David Sinclair reported that the red wine molecule resveratrol profoundly activated the Sirtuin1 gene better than other small molecules. The opposite signal, Sirtuin1 gene inhibition, was said to emanate from niacin (aka nicotinic acid), a ubiquitous nutrient in food. So the food/no-food signal inhibits/activates Sirtuin1.