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How the world got lost on
the road to an anti-aging pill
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May 9, 2016: by Bill Sardi
Researchers now turn toward resveratrol to activate a direct cancer cell-killing effect via activation of natural killer cells in a new era of immune-cell cancer therapy.
Natural killer cells are a class of white blood cells that comprise a small fraction of all the white blood cells in the blood circulation but can have profound anti-tumor effect.
Natural killer cells can target cancer cells without prior “priming” as other white blood cells are required to do. Natural killer cells can recognize and eliminate tumor and virus-infected cells, some parasites and certain types of bacteria by release of toxic substances such as interferon. [International Journal Molecular Sciences 2016]
April 26, 2016: by Bill Sardi
April 24, 2016: by Bill Sardi
It has been recognized for over a decade that red wine molecules known as polyphenols favorably alter the makeup of gut bacteria to reduce risk for colon cancer and inhibit growth of implanted tumor cells. [Mutation Research 2005] But until a recently reported study strikingly demonstrated how resveratrol inhibits accumulation of fatty plaques in the walls of arteries via its ability to alter the composition of bacteria in the intestines, this indirect mechanism has been largely overlooked. [MBio April 5, 2016]
The ability of red wine molecules to foster the growth of healthy bacteria in the intestines, namely Bifidus, is now well established. [Redox Biology 2014; Food & Function 2016; Journal Clinical Gastroenterology 2012]
April 11, 2016: by Bill Sardi
The ability of the red wine molecule resveratrol (res-vair-ah-trol) to favorably alter the family of bacteria in the human digestive tract known as the microbiome is just now beginning to be appreciated. [ResveratrolNews.com January 7, 2016] A new revelation is that resveratrol inhibits a chemical in the gut that is implicated in arterial disease (atherosclerosis). [American Society Microbiology]
Investigators used lab mice that were genetically altered to be prone to atherosclerosis (fatty plaque buildup in arteries) to make it easier to prove their point.
More than 90% of the bacteria in the human gut come from two groups – Bacteroidetes and Firmicutes. Mice fed a choline-rich diet (example: eggs) that markedly increases the bacterial concentrations of Bacteroides and decreases the concentrations of Firmicutes compared to mice given normal animal chow. Choline decreases Bacteroides — Lactobacillus acidophilus and Bifidobactium, considered to be “good bacteria.”
March 29, 2016: by Bill Sardi
According to a compilation of recently published science the red wine molecule resveratrol (res-vair-ah-trol) is poised to open an era of regenerative medicine that could profoundly add many years to the healthspan and lifespan of Americans.
Why? Because, as researchers recently pointed out, any technology that delays the age-related decline in the human immune system could result in a generation of senior Americans who live 120 healthy years or more. [Ebiomedicine 2016]
While American medicine has stumbled around for the past decade or two debating how to do this [Immunology Reviews 2005], resveratrol has now been found to counter virtually all of the genetic pathways that lead to the age-related decline in the human immune system, a fate that affects virtually all senior adults over age 60 and results in otherwise avoidable cases of pneumonia and cancer as well as chronic inflammation and autoimmune disorders.
March 12, 2016: by Bill Sardi
Resveratrol pills are posed as a molecular mimic of a limited calorie diet. Short of a ten-decades long study it may be difficult to produce conclusive evidence that resveratrol pills promote the same lifespan-healthspan doubling effect of a calorie-restricted diet in laboratory animals. Such a study would be impractical as well as exceedingly expensive.
Longevity seekers must rely upon animal studies or markers of human aging to measure whether an intervention like daily resveratrol (rez-vair-ah-trol) consumption would be worthwhile
Will resveratrol pills significantly extend the healthspan and lifespan of humans? There may now be a partial answer to that question, though it takes reading some round-about science.
February 6, 2016: by Bill Sardi
Strikingly, researchers report that life-long administration of a modest dose of the red wine molecule resveratrol (rez-vair-ah-trol) given to laboratory mice keeps their visual system intact and retains their retinal sensitivity to light via activation of the Sirtuin1 survival gene. [Biochemical & Biophysical Research Communications 2015]
With advancing age the retinas of humans and animals lose sensitivity as measured by the electrical response of retinal cells (rods and cones) to light stimulation. But when these animals are given life-long (19 months, equivalent to ~65 years in a human) oral doses of resveratrol, their retinal sensitivity approximates a youthful state.
January 21, 2016: by Bill Sardi
In 2009 I wrote about resveratrol theoretically replacing marijuana because this red wine molecule targets the same cell receptor site (endocannabinoid receptor) as marijuana and its chief molecule cannabis or more specifically tetrahydrocannabinol. [ResveratrolNews.com]
When I wrote that report over six years ago there was not all the public interest in cannabis as there is today with legalization in some US States. So this topic is worthy of a scientific update.
As an update, a recent report compares the ability of resveratrol to target the cannabinoid cell surface receptor as amitriptyline (Elavil), a popular antidepressant and nerve pain medication. [Psychopharmacology Jan 20, 2016]
January 19, 2016: by Bill Sardi
Cardiac researchers writing in the International Journal of Vitamin Nutrition Research report the combination of low-doses of the red wine molecule resveratrol plus vitamin D results in profound prevention of heart muscle damage following an experimentally induced heart attack in animals.
The area of scarring (fibrosis) of heart muscle tissue was reduced from 41.3% in untreated animals to 30.1% (28% reduction) in resveratrol-treated animals and an astounding 17.6% in animal treated with low-dose resveratrol + vitamin D (57% reduction!). This report is groundbreaking and unprecedented. It could signal a new era in preventive heart care far above what a daily aspirin tablet offers.
January 11, 2016: by Bill Sardi
The ineffectiveness and side effects of flu vaccines has resulted in lack of public demand for flu shots. Today, less than half of Americans believe flu shots will help them avoid illness and a third don’t believe they will protect them at all. [Harris Poll, WebMD Dec 15, 2015] The ineffectiveness of the flu vaccine has been well documented. [Knowledge of Health]
Outside of vaccines, a limited number of antiviral drugs are available and the problem of drug resistance looms. The widely used drug Tamiflu has been declared ineffective. [BBC News April 10, 2014]