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How the world got lost on
the road to an anti-aging pill
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January 21, 2016: by Bill Sardi
In 2009 I wrote about resveratrol theoretically replacing marijuana because this red wine molecule targets the same cell receptor site (endocannabinoid receptor) as marijuana and its chief molecule cannabis or more specifically tetrahydrocannabinol. [ResveratrolNews.com]
When I wrote that report over six years ago there was not all the public interest in cannabis as there is today with legalization in some US States. So this topic is worthy of a scientific update.
As an update, a recent report compares the ability of resveratrol to target the cannabinoid cell surface receptor as amitriptyline (Elavil), a popular antidepressant and nerve pain medication. [Psychopharmacology Jan 20, 2016]
January 19, 2016: by Bill Sardi
Cardiac researchers writing in the International Journal of Vitamin Nutrition Research report the combination of low-doses of the red wine molecule resveratrol plus vitamin D results in profound prevention of heart muscle damage following an experimentally induced heart attack in animals.
The area of scarring (fibrosis) of heart muscle tissue was reduced from 41.3% in untreated animals to 30.1% (28% reduction) in resveratrol-treated animals and an astounding 17.6% in animal treated with low-dose resveratrol + vitamin D (57% reduction!). This report is groundbreaking and unprecedented. It could signal a new era in preventive heart care far above what a daily aspirin tablet offers.
January 11, 2016: by Bill Sardi
The ineffectiveness and side effects of flu vaccines has resulted in lack of public demand for flu shots. Today, less than half of Americans believe flu shots will help them avoid illness and a third don’t believe they will protect them at all. [Harris Poll, WebMD Dec 15, 2015] The ineffectiveness of the flu vaccine has been well documented. [Knowledge of Health]
Outside of vaccines, a limited number of antiviral drugs are available and the problem of drug resistance looms. The widely used drug Tamiflu has been declared ineffective. [BBC News April 10, 2014]
January 7, 2016: by Bill Sardi
With recognition that microorganisms that reside in the human digestive tract act as the body’s “second brain,” that the 100-million nerve cells in the gut carry information from the digestive tract to the brain and not the other way around to influence behavior and mood is a recent scientific revelation. [Scientific American 2010; CNS Neurological Disorders Drug Targets 2014]
This new scientific understanding is referred to as the “gut-brain axis” is now recognized as a regulator of mood, cognition (thinking), pain, mood, sleep and eating behavior. [Advances Applied Microbiology 2015]
Microbes that are out of balance in the digestive tract (a condition called dysbiosis where there are too few beneficial bacteria and an overgrowth of bad bacteria such as yeast/Candida and parasites) are not only involved in metabolic disorders (i.e. obesity) but also in emotional behavior.
December 28, 2015: by Bill Sardi
While it will be said that resveratrol is an unproven (but not disproven) pain reliever, it may be a safer and more effective reliever from the agony of chronic pain than existing pain remedies, both prescription and non-prescription.
Recently research discovered why some people are less sensitive to pain than others. A master pain switch has been discovered. Pain is controlled by a cellular sodium channel which permit pain signals to pass along nerve cell membranes. People born without a functioning sodium channel called Nav1.7 do not feel pain. Without this sodium channel, low levels of internal opioids (natural narcotics) are naturally produced. Sodium channel-blocking drugs are used as local anesthetics but are unfortunately unsuitable for long-term pain relief as they induce complete numbness. [Nature Communications 2015]
December 21, 2015: by Bill Sardi
What a year in anti-aging research and anti-aging pill offerings. An article in The Daily Beast called it “The Year We Decided To Live Forever,” referring to the billionaires (Peter Thiel, Breakout Labs; Larry Ellison, Oracle CEO; Paul Glenn, anti-aging philanthropist; Larry Page, Google co-founder, Calico; Craig Venter, Human Longevity) who have dedicated hundreds of millions of dollars in the pursuit of biological immortality. [Daily Beast Dec 4, 2015]
Researchers say the world may finally get an anti-aging pill, but it will be on their terms. Somebody has to pay back the millions of dollars being invested in developmental drugs for what has been called “the greatest problem of our time” – aging.
December 15, 2015: by Bill Sardi
Given the assumption humanity is not going to deprive itself of food to live an extra 40-50 healthy years (healthspan and lifespan doubles among calorie restricted animals), biological short cuts in the form of molecular mimics of calorie restriction appear more practical. Widespread use of properly dosed small molecules could achieve super-longevity only rivaled by the Biblical patriarchs.
Mild biological stress activates cellular defenses. Small molecules, as presented here, that can pass through cell walls and enter the nucleus and favorably influence genetic machinery are abundant in nature. Cells with a mass of less tan 100 nanometers (billion of a meter) in one direction can absorb molecules and pass through the blood/ brain barrier. [Nanomedicine 2011] Many natural molecules already are smaller than 100 nanometers and don’t require nanosizing to enter cells. [Knowledge of Health]
October 26, 2015: by Bill Sardi
1000 AD: — “Here, eat this herb.”
1700 AD: — “That herb is an old wives’ tale; take this elixir.”
1900 AD: — “That elixir is quackery; take this pill.”
1960 AD: — “That pill doesn’t do any good; take this antibiotic.”
2015 AD: — “That antibiotic isn’t safe; take this herb.”
Modern medicine has reveled for over a decade in the most stupendous advancement in the history of cancer therapy, a drug discovery that added decades to the lives of patients with chronic myelogenous leukemia (CML) via a gene-targeted enzyme inhibitor. CML is the most common form of leukemia with around 5000 new cases diagnosed annually.
October 19, 2015: by Bill Sardi
East Indian-born, University of Connecticut researcher Dipak Das PhD (deceased) has become a poster boy for scientific fraud.Or was the witch-hunt launched against him a fraud in itself?
In 2012 popular radio show host Rush Limbaugh announced that Dr. Das “made it all up,” that is, all the science he published to show that the red wine molecule resveratrol protects the heart from damage before a heart attack occurs, considered the best form of cardio-protection said Dipak Das at the time.
October 14, 2015: by Bill Sardi
Bring on the wheat germ. Come to find it is loaded with a polyamine molecule that prolongs the lifespan of many life forms including mammals when supplemented in the diet. That molecule is abundantly found in wheat germ.
Polyamines are identified as putrescine, spermine and spermidine. They are synthesized internally from the amino acid ornithine. Polyamines are also consumed in the diet and play an important role in regulation of cell growth and immune response. [Nutrition 2007]
Biologists excitedly say polyamines found in many foods may reset the body’s 24-hour circadian clock and prolong the healthspan and lifespan of humans. [Cell Metabolism 2015]