test your knowledge
How the world got lost on
the road to an anti-aging pill
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February 11, 2013: by Bill Sardi
Biotechnologist Dr. Bruce Bryan emails to say his grandmother, who lived to 109 years of age, in good health most of the way, because he gave her 5 milligrams of deprenyl every morning.
Deprenyl (selegiline) is a drug that was developed in the 1960s for its anti-depressant effects (it is a monoamine oxidase MAO enzyme inhibitor) and is now primarily prescribed for Parkinson’s disease sufferers (trade names Eldepryl, Emsam, Zelapar, Azilect). It is surprising to learn that deprenyl (selegiline) is a molecule similar to methamphetamine, an illicit street drug, but is not psycho-active nor does it create addiction.
In the mid-1990s animal experiments revealed deprenyl prolongs life, first demonstrated in rodents and then dogs. It also was discovered that Deprenyl not only inhibited MAO but it worked in the brain by increasing the activity of internal (endogenous) antioxidant enzymes catalase and superoxide dismutase (SOD). However, deprenyl doesn’t activate glutathione like resveratrol does.
January 25, 2013: by Bill Sardi
Well, lab mice are not humans, and they are fed in a controlled manner whereas humans can pony over to the kitchen and engorge themselves in snack foods, but resveratrol-fed animals exhibited far less arterial plaque (-52%) than animals given a statin drug (-40%). Furthermore, resveratrol equaled the reduction of circulating cholesterol as a statin drug (-19%). Since statin drugs do not prevent mortal heart attacks, but resveratrol pills do (at least in the animal lab), one wonders if it’s time to abandon Lipitor. — Bill Sardi, Resveratrolnews.com
January 22, 2013: by Bill Sardi
The National Institutes of Health defines dyslexia as a developmental reading disorder or disability that occurs when the brain does not properly recognize and process certain symbols. Noted artist Elizabeth Berg has struggled with a more severe form of this disability for nearly six decades. As far back as Elizabeth can remember she was dyslexic.
Her earliest recall was when others pointed her disability out to her. Letters actually moved on the printed page. Letters like “b” were seen as a “d.” Her mother provided her with building blocks with raised letters on them to help her imprint the proper configuration of letters into her mind.
This disability didn’t hinder Lisa, as she is fondly called. She became a child prodigy and entered art college at a major university while still a young teenager.
January 21, 2013: by Bill Sardi
Hartford, CT (Jan 20, 2013)- Noted red wine molecule heart researcher Dipak Das PhD has filed a $35 million defamation claim against the University of Connecticut (U CONN) Health Center for wrongful termination, violation of the university’s by-laws, and lack of due process as protected by the 14th Amendment to the United States Constitution.
Dr. Das made worldwide headlines in January of 2012 when U CONN authorities issued a press release and posted a website alleging 145 claims of scientific fraud that were backed by 60,000 pages of evidence. However, that website was quickly taken offline after many of its allegations were publicly rebutted. Soon thereafter, it came to light that the university’s review board had never read the entire report and has instead relied upon a 23-page summary in its decision to dismiss Dr. Das from his position as director of the Cardiovascular Research Center at the UCONN Health Center.
Dr. Das conducted landmark animal studies that demonstrated the red wine molecule resveratrol (rez-vair-ah-troll) can limit damage to the animal heart during a heart attack and turn a mortal heart attack into a non-mortal event.
January 7, 2013: by Bill Sardi
Professor Ole Vang
The release of your (mis)information from the RESVERATROL 2012 conclave is almost laughable. I’m laughing in my tears. Sadly, so many suffer from inability of the “resveratrol community” to come to any conclusions. How many more wasted decades before the professors can come to any agreement?
While your press statements said “there is not yet scientific evidence to recommend a general intake of resveratrol for prevention of lifestyle diseases,” and “trials in humans are necessary … to be absolutely sure of positive effects in humans,” your plea for more studies is falling on deaf ears.
January 3, 2013: by Bill Sardi
Report: RESVERATROL 2012 2nd International Conference of Resveratrol and Health (December 8, Leicester, England)
“Committee: a group of men who individually can do nothing, but as a group decide that nothing can be done.”
A collaborative group of scientific investigators, resveratrol raw-material manufacturers and branders of commercially available resveratrol-based products met in Leicester, England to chart the future direction for this miraculous natural molecule. The group covered a broad range of disorders that resveratrol addresses, which includes aging and cancer as well as important other issues such as optimal dosing and models for testing. Their full report can be read online here.
While the group concluded there is not unequivocal scientific data to support resveratrol for disease prevention in humans (OK for lab mice however) or human life extension (the only way to conclusively show resveratrol extends human life is to conduct a 99-year study), it did say there are encouraging preliminary results.
January 2, 2013: by Bill Sardi
In a free market, with an un-manipulated news media and a medical establishment open to less problematic and more economical cures, the announcement today by Dr. Stuart Richer OD, PhD, Director of Ocular Preventive Medicine at the Eye Clinic, James A Lovell Federal Health Care Center – North Chicago, would have been splashed on the front page of newspapers throughout the world.
The public would have stood in fascination at the prospect of damaged tissues in their brain, heart or eyes simultaneously repaired without invasive techniques. The idea of not having to wait decades to apply this discovery would have caused telephone lines across the world to become overloaded. But that is not the world we live in today.
December 31, 2012: by ResveratrolNews
North Chicago, IL (December 31, 2012) – The first report using molecular medicine to regenerate damaged tissues in the back of the human eye via use of small antioxidant molecules to promote survival of internally-produced stem cells is being reported today. It may be the first successful report of cellular or tissue regeneration via internally-derived stem cells in all of medicine.
In a newly published scientific book (Advancing Medicine With Food & Nutrients, 2nd edition, CRC Press (Ingrid Kohlstadt, editor), Dec 2012), Dr. Stuart Richer, OD, PhD, Director, Ocular Preventive Medicine- Eye Clinic at the James A Lovell Federal (Veterans) Health Care Center in North Chicago, presents striking photographic evidence of stem cell regeneration of damaged tissues at the back of the eye of a patient with dry macular degeneration accompanied by restoration of vision after using a nutriceutical comprised of small natural antioxidant molecules.
December 27, 2012: by Bill Sardi
For the uninitiated: resveratrol (rez-vair-ah-trol) is known as a red wine molecule that is that is believed to be chiefly, but not solely, responsible for the heart-healthy effects of red wine.
The year 2012 started out with maybe half of all resveratrol pill users abandoning their use after hearing allegations that the leading researcher in the field had committed scientific fraud. The researcher, Dipak Das PhD, working at the University of Connecticut (U CONN), was alleged to have fabricated data to gain research grant money and according to radio talk show host Rush Limbaugh, Dr. Das “made it all up” (the science that is).
While over 350 news sources covered the story, they were simply parroting allegations made by a 5-man U CONN review board, a board that concedes it never read the university’s 60,000 page evidence report and could not produce for Dr. Das’ legal counsel the original evidence disc which it said was lost. In fact, U CONN never gave Dr. Das due process and took its website offline when it was challenged to validate various facts that were egregiously inaccurate. But the damage had been done.
December 21, 2012: by ResveratrolNews
By Tan Ee Lyn
HONG KONG | Thu Dec 20, 2012 7:55am EST
(Reuters) – Scientists in Hong Kong appear to have mapped out a formula that can delay the aging process in mice, a discovery they hope to replicate in people.
Their finding, published in the December issue of Cell Metabolism, builds on their work in 2005 which shed light on premature aging, or progeria, a rare genetic disease that affects one in four million babies.
Progeria is obvious in the appearance of a child before it is a year old. Although their mental faculties are normal, they stop growing, lose body fat and suffer from wrinkled skin and hair loss. Like old people, they suffer stiff joints and a buildup of plaque in arteries which can lead to heart disease and stroke. Most die before they are 20 years old.
In that research, the team at the University of Hong Kong found that a mutation in the Lamin A protein, which lines the nucleus in human cells, disrupted the repair process in cells, thus resulting in accelerated aging.