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How the world got lost on
the road to an anti-aging pill
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July 28, 2013: by Bill Sardi
San Dimas, CA (July 28, 2012) – Researchers report calorie-restricted diets and red wine resveratrol (rez-vair-ah-trol) pills beneficially alter the same array of genes in both healthy and unhealthy individuals but may only produce measurable physiologic improvement in inflammation, blood pressure, blood sugar, insulin sensitivity and weight among individuals with metabolic problems (diabetes, obesity).
Healthy adults taking resveratrol pills aren’t wasting their money buying resveratrol pills as researchers surmise this favorable activation of genes will produce future health benefits via “metabolic re-programming effects.” Researchers are calling for long-term studies to validate their theory.
Because long-term calorie restricted diets progressively alter more and more genes (831 in laboratory mice) over a lifetime, it is assumed healthy adults who habitually take resveratrol pills will progressively activate more genes over time and derive unparalleled health benefits similar to those observed among laboratory mice on life-long calorie restricted diets. Calorie restriction doubles the lifespan and improves the health span of most animal species.
July 26, 2013: by Bill Sardi
Researchers at the University of Copenhagen say they take my allegations of maligned science very seriously. They weakly defend their preposterous claim that resveratrol produces a significant reversal of the effects of physical exercise. Here is my response to their email:
To: Mr. Gliemann (student, PhD candidate):
Maybe you have learned to fool yourself with your own numbers.
At no time did resveratrol meaningfully (but maybe, just barely, statistically) negate the effects of exercise.
July 22, 2013: by Bill Sardi
Las Vegas, NV (July 22, 2013) – Well, the above headline is not the one you are reading in today’s news.
What you are reading is:
“Red wine blunts benefits of exercise in men” -The Indian Express
“Too Many Antioxidants? Resveratrol blocks many cardiovascular benefits of exercise” -Science Daily
“Glass of red could undo the effects of exercising” (Express UK)
“La ‘píldora de la eterna juventud’ es cuestionada (the pill of eternal youth is questioned) (La Nacion Costa Rica)
A bevy of prior studies conducted in mice came to contrary conclusions. Mice on treadmills improved their endurance and stamina and many measurable parameters of health improved as well. But moving from mice to men is another thing. So why the disparity between studies with laboratory mice under controlled dietary and environmental conditions and senior (human) males in a placebo-compared trial?
July 21, 2013: by Bill Sardi
“Molecular biologists are taking backward steps in calling for scientific studies that have already taken place. They are asking for scientific ground to be covered that has already been covered.”
Those are the terse words of Bill Sardi, managing partner for LONGEVINEX®, the world’s best tested resveratrol pill, in sharply written responses to recently published scientific reports calling for further study of red wine resveratrol pills.
“Molecular biologists are calling for research to be conducted with resveratrol pills that represent two steps backwards. Specifically they are calling for advanced encapsulation technology and studies comparing resveratrol to a calorie restricted diet, both which have already been achieved by Longevinex®, Sardi emphasizes.
June 25, 2013: by Bill Sardi
Good News For Men- Resveratrol Restores Erectile Dysfunction In Diabetic Lab Rats.
The patents on Viagra just recently expired and prices are falling for generic Viagra, but a recent study suggests the red wine molecule resveratrol (rez-vair-ah-trol), taken at a dose of 5 milligrams per kilogram (2.2 lbs) of body weight (equivalent to ~350 mg for a 160-lb adult male), restores erectile function among diabetic animals. Lower doses probably work as well. Mega-dose resveratrol may be problematic.
Erectile dysfunction plagues males with elevated blood sugar levels. Erectile dysfunction is estimated to affect between 35% and 75% of diabetic males, which is three times higher than the incidence in non-diabetic men. ©2013 Bill Sardi, ResveratrolNews.com
June 24, 2013: by Bill Sardi
It is ironic that two noted biological researchers, one who was arguably the most prominent biologist in the early 1900s, and another extant laboratory investigator almost one-hundred years later, would both get tripped up on some seemingly innocuous ink blots.
It was Paul Kammerer himself, the discredited biologist of yesteryear who allegedly conducted specious breeding experiments with amphibious animals (salamanders, olms, toads), who had a side hobby of collecting data on odd coincidences. (Kammerer wrote an entire text on the subject (Das Gesetz der Serie – The Law Of Seriality- 1919).
In a historical repeat of Kammerer’s concept of seriality, a living biologist has also been falsely accused of scientific deception as was Kammerer, in a modern replay of the case of the incriminating ink blots.
May 27, 2013: by Bill Sardi
Well, that is oft repeated statement by mindless biologists who don’t really delve into this matter. Technically they are correct. Resveratrol is fully metabolized (taken out of action) after it has made a few passes through the liver (a process that can be delayed by taking quercetin with resveratrol). Liver metabolism involves coupling resveratrol with detoxification molecules (sulfate, glucuronate) produced in the liver. Resveratrol is then too large a molecule coupled to a carrier protein to pass through cells walls and influence genetic machinery inside cells. However, an enzyme (glucuronidase) that is abundant at sites of inflammation, infection and malignancy unlocks resveratrol at the right time and place, freeing it to switch genes and act as an important copper-binding antioxidant. The very fact resveratrol produces systemic-wide biological effects in compartmentalized organs such as the brain, heart, kidneys, suggests it is biologically active, even passing the blood-brain barrier.
May 2, 2013: by Bill Sardi
The anticipation builds for anti-cancer drugs that target a broad array of genes that combat various types of cancer in different organs rather than a different drug for each cancer by their anatomical origin. Instead of anti-cancer drugs for each organ, such as lung, prostate, breast and colon, geneticists now say new drugs in development may address many forms of cancer.
The first examples of this new thinking are studies published in the New England Journal of Medicine showing uterine cancer and leukemia have similar genetic fingerprints and could be treated by the same drug. A large effort to this end is being commandeered at the Cancer Genome Atlas website.
However, the thinking is far too narrow now that geneticists know diseases are integrated via gene networks. An online map can be viewed showing genes in many diseases overlap one another (note: it takes time to load).
April 21, 2013: by Bill Sardi
While there has been much talk about Sirtuin-1 as the survival gene that is activated by life-prolonging calorie restriction, researchers report that Sirtuin-3 gene protein activates a protective internal antioxidant known as SOD-2 (superoxide dismutase-2) which in turn rejuvenates blood stem cells. It was previously thought that DNA damage to old blood stem cells is irreversible, but this aging process (DNA damage) was reversed when Sirtuin-3 gene protein is produced. Stem cells are unspecialized cells that can turn into heart, brain, muscle, nerve or other types of cells and are needed for repair of damaged cells and tissues.
The red wine molecule resveratrol is known to activate the Sirtuin-3 gene. Longevinex, a branded resveratrol dietary supplement, has been shown to increase Sirtuin-3 gene protein 295% greater than plain resveratrol. Read the abstract of the report below.
April 12, 2013: by Bill Sardi
In a landmark study, researchers have linked elevated blood-serum iron levels with shorter end caps (telomeres) on chromosomes. Shorter telomere length is associated with increased incidence of age-related disease and mortality. Telomere length has emerged as a marker for biological aging and is associated with shorter lifespan.
The results of this study may also help explain why telomere length is determined by gender as women have lower iron levels throughout most of life due to menstrual losses and are reported to have longer telomeres and a longer lifespan than males.
This study also points to interventions such as blood-letting and dietary avoidance of iron-rich foods to maintain telomeres and prolong human lifespan.