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How the world got lost on
the road to an anti-aging pill
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June 8, 2015: by Bill Sardi
Despite an archive of over 73,000 research papers published in the last two decades on the subject of Alzheimer’s disease, little clinical progress has been made relative to how people can avoid this devastating brain disease. [Biofactors March-April 2012]
Alzheimer’s memory loss is a dreaded mental condition. Surprisingly, only 5% of cases of Alzheimer’s are related to family history and 95% of cases present with sporadic symptoms whose origins are likely dietary and environmental. [Molecular Neurobiology Dec 2013] For example, refined sugar intake is consistently associated with mental impairment. [Current Opinion Clinical Nutrition Metabolic Care July 2013]
May 9, 2015: by Bill Sardi
Question: Should resveratrol users also add niacin-like pills to their dietary supplement regimen?
Answer: A decade ago David Sinclair PhD at Harvard Medical School announced the red wine molecule resveratrol molecularly mimicked a life-and-health prolonging calorie restricted diet. Humans would not need to deprive themselves of food to double their healthspan and lifespan as demonstrated in the animal laboratory.
The opposite biological signal of food deprivation is provided by niacin (vitamin B3) since it is ubiquitous in foods. So should niacin be avoided when taking resveratrol pills? We don’t want to send two biological signals at the same time do we?
The biological answer to that question gets a bit complicated.
May 4, 2015: by Bill Sardi
You didn’t read the above headline in any news reports this week.
Four years ago researchers in Japan reported that the red wine molecule resveratrol maintains and even reverses mutations in a key gene (Werner Syndrome Gene or WRN gene) that is involved in maintenance and repair of DNA and telomeres, the end caps of chromosomes. [Current Aging Science Feb 2011]
Also, another study published nearly 7 years ago found that resveratrol activates the Sirtuin1 survival gene and stabilizes bundles of human genes, the same gene bundles called chromatin that researchers now link with human aging. [Cancer Cell Oct 7, 2008]
April 16, 2015: by Bill Sardi
Researchers announce in the Journal of Neuroscience that the use of a small synthetic molecule drug (difluoromethylornithine or DFMO) improves memory in laboratory mice by virtue of its ability to inhibit arginase, an enzyme that degrades the amino acid arginine. [MedicalXpress]
In 2009 researchers began to explore the role that a shortage of the amino acid arginine plays in the development of Alzheimer’s disease. Arginine plays many roles in the body, enhancing immunity, controlling insulin activity and reducing inflammation, but arginine is largely known as the precursor for nitric oxide gas, a dilator (widener) of blood vessels.
April 12, 2015: by Bill Sardi
I wrote on this topic just a little over a month ago, but the pace of change in the anti-aging field is so fast that it seems like a decade ago. [ResveratrolNews.com Feb 15, 2015]
The focus of my report last month was more about breakthrough developments and commercialized products now available that address what would be considered the greatest challenge that mankind has ever faced – the quest to conquer mortality.
: by Bill Sardi
Recently this author has underscored the importance of sugar restriction in the control of cancer. [KnowledgeofHealth.com] Newly published science provides further insight into the importance of low-carbohydrate (bread, rice, pasta) and low-sugar diets to improve cancer survival. A new finding is how a restricted sugar/carbohydrate diet enables anti-cancer molecules such as resveratrol to exert their anti-cancer properties.
Investigators wondered if a low-carbohydrate diet combined with molecules that genetically mimic a limited calorie diet would improve cancer survival rates.
March 28, 2015: by Bill Sardi
The red wine molecule resveratrol (rez-vair-ah-trol) has just recently been added to the growing list of nutrients (fish oil, B vitamins, vitamin C, vitamin D) that improve mental performance and slow and even reverse brain shrinkage with advancing age. [Journal Neuroscience June 4, 2014]
Resveratrol didn’t just improve the ability of laboratory mice to remember how to navigate through mazes but actually improved the memory of healthy seniors (word recall scores) which was correlated with decreases in blood sugar (hemoglobin A1c test) and body fat and improved connectivity between the memory formation part of the brain (the hippocampus) and the emotional control center of the brain (frontal cortex). Resveratrol also increased the size of the hippocampus and frontal cortex, critical areas of the brain that facilitate memory.
February 23, 2015: by Bill Sardi
A decade after the red wine molecule resveratrol (rez-vair-ah-trol) was introduced as an anti-aging pill, molecular biologists, as they are called, have introduced a whole new strategy that promises to produce nearly ageless humans who will live an indefinitely long and healthy lifespan.
These new “high-brow” youth pills come sans all the hype and hyperbole that accompanied resveratrol dietary supplements when they were first introduced and marketed by online hucksters who offered a free bottle of red wine pills to consumers who suddenly found their credit cards being billed each month without their knowledge.
February 19, 2015: by Bill Sardi
After a decade of scientific misdirection the discoveries involving the red wine molecule resveratrol unrelentingly continue to be published in scientific journals. Human studies are beginning to show resveratrol is relatively safe (safer than aspirin) and remarkably effective in human studies involving maladies of the eyes, brain, liver and heart, particularly when taken in modest but higher-than-dietary-level doses. Its versatility to address so many biological factors that affect aging is nothing less than remarkable. Among these reported advances is an astonishing discovery involving the aging human brain.
Small hemorrhages in the brain are now believed to be the cause of age-related mental decline, not the widely reported beta amyloid brain plaque or excessive acetycholinesterase enzyme that literally erases the brain chemical acetycholine, known as a memory molecule. [Nature Reviews Neurology May 2006; MedScape June 17, 2011] Acetycholinesterase inhibitors (Aricept, Exelon, Cognex, Razadyne) have been a flop for Alzheimer’s disease memory loss. [European Journal Clinical Pharmacology July 2005]
February 15, 2015: by Bill Sardi
In the wake of the Attorney General of the State of New York maligning herbal supplements, to claim herbal remedies sold in major store chains are mislabeled and often contain nothing more than powdered rice and houseplants as fillers, an MIT-based nutraceutical (aka dietary supplement) company has been spawned to introduce a scientifically valid anti-aging pill.
Dietary supplements, widely dismissed by physicians for not being “FDA approved” and unfairly maligned by the research community and the news media, may finally be getting some respect. But only in the context that an anti-aging pill is beyond the charter of the FDA which is to approve molecules, both natural and synthetic, that are safe and effective in the prevention, treatment or cure of disease. Aging is not considered a disease per se and conclusive evidence an anti-aging agent works might take decades to validate. So the more economical, more practical route of introducing an anti-aging pill as a dietary supplement has been taken by one of the most esteemed scientific centers in the world – Massachusetts Institute of Technology.