test your knowledge
How the world got lost on
the road to an anti-aging pill
Subscribe to our newsletter to receive email notifications when new articles are posted.
December 23, 2014: by Bill Sardi
After learning resveratrol was first discovered in 1939 and that there have been over 7000 research reports and reviews published in scientific journals dating back to 1978 involving this red wine molecule, it is difficult to fathom a major discovery involving a critically important gene target of resveratrol has just now been uncovered. But that is the news headline today. [Medical Xpress Dec 22, 2014]
Resveratrol (rez-vair-ah-trol) has been found to molecularly mimic the amino acid tyrosine and simulate protective biological mechanisms that occur during starvation say researchers at Scripps Institute. Their report is published in the December 22 early online issue of Nature. [Nature Dec 22, 2014]
Read the whole post »
December 16, 2014: by Bill Sardi
Longevity seekers often pay too much attention to lengthening telomeres, those end caps on our chromosomes, or even activation of known longevity genes such as the sirtuin1 survival gene. The question remains: precisely what causes humans to get old and why does the rate of aging differ from individual to individual? What influences genes to accelerate or slow the rate of aging? The same library of ~20,000 genes is housed inside the billions of cells in every human body. What causes one person’s set of genes to age them faster than another individual?
December 9, 2014: by Bill Sardi
A. I think of all the various theories about why humans age, the antioxidant theory, the hormonal theory, the wear-and-tear theory, the mitochondrial theory, the telomere theory, the immune theory, (there are many more), none of them help explain why humans age at three different speeds. Whatever theory of aging that is put to the test should consider this fact.
The 3-speeds of human aging idea springs from studies that measure the rate of deposition of cellular “garbage.” The buildup of “toxic waste” is said to be responsible for the curse of aging. [Science Aging Knowledge & Environment Feb 2, 2005]
November 27, 2014: by Bill Sardi
It was heralded in 1997 as the most promising anti-cancer molecule found in nature. [Science Jan 10, 10997]
It stops cancer in all three stages of development (initiation, growth and spread), unlike any existing anti-cancer drug. [Cancer Prevention Research May 2009]
It inhibits the development of new blood vessels that feeds tumors. [International Journal Oncology Dec 2013]
November 24, 2014: by Bill Sardi
November 17, 2014: by Bill Sardi
November 14, 2014: by Bill Sardi
Reporting in the journal ALCOHOL, researchers at the University of Gothenberg incorrectly conclude that alcohol and red wine offers little benefit to healthy people seeking to keep their hearts healthy. Their study measured reduction of HDL cholesterol and presumed reduction of coronary heart disease. [Alcohol Nov. 2014] A news headline says: “Bad News For People Who Think Alcohol Is Healthy.” [Huffington Post Nov 13, 32014] But the conclusion of their study should have been that HDL cholesterol, not alcohol, has little effect on coronary heart disease.
November 9, 2014: by Bill Sardi
November 4, 2014: by Bill Sardi
October 5, 2014: by Bill Sardi
Researchers now recognize that autism involves modifiable genetic factors in the brain. In the proposed therapy genes are not structurally altered but their ability to make proteins (called gene expression) is modified by use of vitamins and other small molecules. It may be possible to molecularly reverse autism. [Epigenomics June 2011]
Only a small fraction of autistic children exhibit gene mutations (structural problems in the DNA ladder). Early environmental exposure to chemicals is strongly suspected as causal. Children today are surrounded by thousands of synthetic chemicals. Two hundred of them are neurotoxic in adult humans, and 1000 more in laboratory models. [Current Opinion Pediatrics April 2010]
Researchers even postulate that seemingly innocuous chemicals in perfumes need to be investigated to see if there is any association with autism since chemicals in perfumes are expected to reach the developing fetal brain. [Medical Hypotheses June 2013]