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How the world got lost on
the road to an anti-aging pill
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July 28, 2014: by Bill Sardi
An immense federal project that involved 440 scientists from 32 laboratories from around the world, a project known as ENCODE, concluded that 80% of the library of human genes (known as the human genome) is biologically functional. The results of ENCODE were reported in September of 2012 and strong criticism of its “extremely loose definition of ‘biologically functional’ soon followed.” [Proceedings National Academy Sciences April 2, 2013; Time Magazine Sept 6, 2012]
ENCODE stunned the world of human genetics at that time as it was believed that only a small fraction (~3%) of genes actually produce proteins.
Yet in another a scientific reversal, just 22-months later scientists at Oxford University report only 8.2% of our DNA is biologically active. Oxford researchers say the rest of the genome is leftover evolutionary material that has undergone mutational losses or gains in the DNA code. [Science Daily July 24, 2014; PLoS Genetics July 24, 2014]
July 19, 2014: by Bill Sardi
Researchers at Cold Spring Harbor Laboratory, writing in a recent edition of The New England Journal of Medicine, claim a reason why supplemental antioxidants have failed to consistently reduce the risk for cancer is that they don’t target the precise location where 90% of oxidation takes place – in cellular power plants called mitochondria. [New England Journal Medicine July 10, 2014; Medscape July 11, 2014]
These researchers are calling for the development of “synthetic” strategies to target the mitochondria and negate the protective effect dietary antioxidants provide cancer cells, ignoring the fact there are many natural antioxidant molecules that already target mitochondria and promote cancer cell death.
July 14, 2014: by Bill Sardi
The prospect of the world’s first FDA-approved anti-aging drug is now being discussed (again). Researchers, writing in the journal AGING CELL point to a survival gene, Sirtuin1 (sir-two-in), as the molecular target to achieve extended healthspan and lifespan and a synthetic drug, SRT2014 (Sirtris Pharmaceuticals) that docks-up to that gene to produce health benefits similar to those achieved with restricted calorie diets.
The first report of aged lab animals maintaining bone (averting osteoporosis) and muscle mass (averting sarcopenia) throughout their lifetime by taking an oral Sirtuin1 activating pill are now reported with the prospect of doing the same in humans. Researchers claim animal experiments demonstrate “that it is possible to design a small molecule that can slow aging and delay multiple age-related diseases in mammals.” [Aging Cell June 16, 2014]
July 7, 2014: by Bill Sardi
In confirmation of the overmineralization theory of aging Harvard Medical School Researchers report that the Sirtuin-3 survival gene, which has been positively linked with longevity in humans, controls iron metabolism in living cells. [Oncogene June 9, 2014]
The Sirtuin-3 gene is known as a mitochondrial gene. There are a few hundred mitochondria in living cells. They produce cellular energy in the form of adenotriphosphate (ATP).
By virtue of its ability to control iron the Sirtuin-3 gene reduces oxidation, suppresses tumor growth and helps to renew old mitochondria in a process called mitogenesis.
June 26, 2014: by Bill Sardi
Is the road to superlongevity to forever remain a perplexing mystery? From time to time news reports tell about people who achieved superlongevity (defined at living 110+ years) and we remain puzzled when these reports attribute their long life to smoking cigars or drinking alcohol.
The self-proclaimed reasons super-longevinarians give for their long life are often quite disparate. One centenarian advises “mind your own business and don’t eat junk food.” Another says: “don’t smoke, don’t drink, eat right and don’t overdo it.” [ModernHealthMonk.com]
But a 107-year old attributes his cigar smoking habit to his longevity. [Death&TaxesMag.com] What are we to make of this?
June 23, 2014: by Bill Sardi
It may come as a surprise to learn that a key and irreplaceable layer of cells in the human retina called retinal pigment epithelium are “immune cells.” That is, they are phagocytes – cells that protect the light-sensitive retina by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells.
Every morning, upon stimulation by light, the human retina sheds used-up vitamin A in a self-renewal process. If the used-up vitamin A is not disposed of properly, cellular debris will accumulate and eventually destroy photo (light) receptor cells. This process describes a serious eye problem called night blindness (retinitis pigmentosa). The red wine molecule resveratrol activates phagocytosis and proper disposal of cellular debris.
May 28, 2014: by Bill Sardi
Over a decade ago the public chose biodegradable plastic, a driverless car and a fully automated home over an anti-aging pill as the most desired inventions. [MIT survey 1997] Today we have driverless cars, semi-automated homes, smart eyeglasses, and humanity is just a step shy of having Dick Tracy wrist radios. So what technologies does the public now want technology to develop?
Philips UK [Philips.co.uk], largely known as a leader in lighting but promotes itself as an innovation company, conducted a survey of 1000 adults in Britain and reports that two-thirds of Britons hope for a cure-all pill over other possible inventions technology can deliver over the next 100 years. [Daily Mail UK May 27, 2014]
May 25, 2014: by Bill Sardi
What you won’t hear about stem cell technology is that it is a flop. Despite billions of dollars of investment money, it is going nowhere. In fact, what is going on today in research labs doesn’t even involve stem cells. You can read more about it at Dr. William Prather’s article entitled “The Unrealized Potential Of Stem Cell Therapy.” [DDD Magazine Oct 2013]
A problem with the stem cell industry is that it becomes so difficult to scuttle a research program that employs so many people at a time when unemployment is a national embarrassment. There are an estimated 6100 full-time employees working in regenerative medicine and over 100 companies involved in stem cell therapies. There were 537 patents filed for stem cell technology in 2007. The National Institutes of Health is reported to have spent $546 million on embryonic stem cell research. [StemCellAction.org] This perpetually promising industry is only in operation as long as it is government subsidized.
May 16, 2014: by Bill Sardi
You can read them all — all 279 of them at GoogleNews. Modern medicine can release falsehoods against one of the most promising dietary supplement ingredients and the news media will propagate it without question.
It’s obvious the nation’s health reporters mindlessly parroted the press release emanating from Johns Hopkins Medicine that errantly claimed the red wine molecule resveratrol (rez-vair-ah-trol) was of worthless value in reducing overall mortality among senior adults living in a wine-making region of Italy over a period of 9 years. Over 279 news reporters never doubted what researchers said. They just re-wrote the news story and hurried it into publication.
May 15, 2014: by Bill Sardi
A man was overheard while standing in the checkout line at a Trader Joe’s market with a bottle of wine in his hand wondering out loud if wine drinking was worth it any more after hearing a recent news report saying the latest long-term (9-year) study showed wine drinking did not lower overall mortality rates among senior adults living in a wine-growing region in Italy. Ah, would even the Italians back away from their traditional wine drinking?
What they should be backing away from is tobacco. My linked report explains the whole mess and reveals how modern medicine is fabricating false information about dietary supplements to no end. [Has The So-Called French Paradox Vanished, Or Just Obscured By A Tobacco Smoke Screen? ] Examine the science for yourself.