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  • Molecular Medicine Could Avert Predicted Catastrophic Vision Loss In The Aged

    January 9, 2011: by ResveratrolNews

    Chennai, India (January 9, 2011) –  While age-related vision loss of catastrophic proportions is predicted in coming decades, rising from 17 million patients today to 55 million by the year 2050, it’s possible this catastrophe could be averted and lost  vision even restored using molecular medicine.

    These are the words of Stuart Richer, OD, PhD, speaking at the 10th annual meeting and International Conference on Recent Trends in Therapeutic Advancement of Free Radical Science, in Chennai, India today.

    Dr. Richer says modern medicine is just beginning to evaluate data from the first cases where conventional medical and surgical efforts to restore lost vision had been exhausted and a molecular medicine approach was employed under  compassionate use.  Even other nutritional therapies including antioxidants were ineffective.  Molecular medicine, where small molecules are utilized that can pass through the blood-retinal barrier and which can influence the genetic machinery inside living cells,  appears to be very promising, says Dr. Richer.

    While this therapy is still unproven, early data indicates larger trials are warranted.  The first cases treated under a molecular medicine protocol provide evidence that not only can visual loss in the later years of life be preserved, but lost vision can be restored, particularly among the most severe cases of retinal disease or what is called advanced macular degeneration, says Dr. Richer.

    “While I must qualify what I am saying by noting that the severity of retinal disease may improve on its own, I have now documented three consecutive cases where molecular medicine appears to have restored the normal architecture of the human retina and measurably improved visual function that could not be accomplished with conventional care.   In one of these cases, vision improved when the patient took an oral a mineral-chelating antioxidant (Longevinex) and deteriorated when the patient ceased taking the antioxidant cocktail, which suggests cause and effect,” he says.

    Dr. Richer showed an audience of stunned researchers the first photographic slides of their kind – old, damaged retinas that are pocked with aging spots, hemorrhages and poor circulation, becoming more youthful and functional over a relatively short period of time. “We simply need to move to larger human trials where we can determine the reliability and safety of this approach.  This can be accomplished within a year, we do not need to wait a decade to conclusively validate this approach,” he says.

    “The small molecules in the nutriceutical cocktail we used, such as resveratrol, quercetin, rice bran phytate, as provided in commercially-available product called Longevinex, appear to work synergistically and more powerfully in animal studies of heart disease, which is why it was chosen for compassionate use in these individual cases of age-related eye disease,” says Dr. Richer.

    These cases were deemed unsuitable by a retinal specialist for medical therapy, which consists of injecting an anti-growth factor drug directly into the eye.  “There were no remaining options for these patients,” says Dr. Richer.

    The possibility of using an oral pill rather than injections directly into the eyes is likely to be more welcomed by patients.  Such a pill would cost less than a dollar a day. Injectable drug therapy costs around $1000 per injection and six or more injections are often required.

    Dr. Richer calls attention to the fact that many senior Americans remain active and drive automobiles but don’t fully recognize their vision is fading, and they are developing blind spots, especially if these changes occur in one eye only.  Age-related visual decline represents a major road hazard he emphasizes.

    “We have growing evidence that molecular medicine can turn mortal heart attacks into non-mortal events and accelerate healing of a damaged heart, and now we are beginning to document that lost vision can be restored, sufficient to help senior adults maintain an active lifestyle, which includes driving an automobile,” he says.

    Dr. Richer’s first case showing molecular medicine improved the vision of an 80-year old man was published in the journal Optometry in 2009.

    Dr. Richer cautions patients with existing macular degeneration to be judicious in their use of nutriceuticals, such as resveratrol pills, since very low doses may be ineffective and mega-doses may actually generate free radicals and be toxic.  He says the nutriceutical formula chosen for his study, unlike other resveratrol pills, was recently documented to be non-toxic at any tested dose.

    “The human retina has tremendous regenerative capacity when molecular medicine is applied,” says Dr. Richer.  “We are just beginning to appreciate and document the value of small natural molecules that can pass through the blood-retinal barrier and influence the genetic machinery within living cells,” he says.

    Resveratrol, known as a red wine molecule, exhibits almost magical properties, promoting new blood vessels which speed healing after a heart attack, but doing the exact opposite in the retina, inhibiting the development of new blood vessels which can destroy vision.

    Dr. Richer is director of Ocular Preventive Medicine and Associate Professor, Family & Preventive Medicine, at the James A. Lovell Federal Health Facility in North Chicago, Illinois. Dr. Richer has no commercial affiliation with Longevinex.

    To learn more, visit

2 Responses to “Molecular Medicine Could Avert Predicted Catastrophic Vision Loss In The Aged”

  1. Bruce Supranowicz Says:
    February 22nd, 2011 at 4:09 am

    I’ve been taking Longevinex on and off for a few years, and continuously for the last two years. Although this may be hard to believe, my vision has improved from about the 20/80 to 20/90 range to around 20/40 to 20/50 during these last two years. I can see many distant objects much better than a couple of years ago, and in much more detail. I cannot explain the gradual improvement in vision except for the fact that I have been taking Longevinex during that time. The study by Dr. Richer seems to make sense in this regard.

    I’ll continue to take Longevinex, as my original intent was for a longer, healthier life, which seems to be the case so far (more energy, no deterioation of strength despite the fact that I’m in my late 50’s, etc.). The previously unanticipated benefit of better eyesight is a plus. Time will tell if my improvement in eyesight continues, but up to this time, it’s been gradually improving month by month for the last couple of years. I’m anxious to see how much more it improves. Needless to say, I’m very happy about the results, as taking Longevinex has served me very well.

    yes, there will soon be announcements that confirm what many Longevinex users have experienced, that this pill has a profound effect at strengthening visual capacity. It apparently has ability to produce youthful vision via its ability to youthify the crystalline lens and the retina. Something very striking is that very old individuals seem to experience dramatic visual improvement, so you are never too old to benefit. -Bill Sardi

  2. George Fitzsimmons Says:
    March 13th, 2011 at 7:22 pm

    Bill Sardi:
    I have been taking Longevinex for a few years and recently switched to Longevinex Advantage when it became available six or so months ago. My left eye suffers from what they call renal vein occulsion where the artery pushes on the vein and restricts the retina return blood flow. The retina swells and attemps to grow new blood vessels. About every six weeks the retina specialists injects Avastin (a cancer drug)into the eye which damps down the swelling and restores some of my limited vision in that eye. This has been going on for about three years.

    The span between my last injection and the most recent injection three daya ago jumped from 6 weeks to 14 weeks and 2 days (from a 42 day average to 100 days). After reading the above article, I believe it is due to Longevinex Advantage’s ability to reduce the retinal stress by some means. I am very excited about this turn of events and made sure my retina specialist here in Reno, NV was delivered a copy of the above article. So, maybe it works for old guys like me, I will turn 80 this year. I have one departing question, would it be appropriate to increase my daily doseage of Longevinex Advantage from two/day?

    Reply: yes, many users of Longevinex are now reporting major visual improvement even after years of poor sight. Studies are underway to validate this. Yes, veins are the blue hoses, as opposed to the red arteries that carry oxygenated blood. The veins facilitate passive return of deoxygenated blood to the heart and they often become weak. The most common vein problem is varicose veins in the legs. A plausible reason why Longevinex Advantage is producing this better result is that it addresses the connective tissue which is a component of the venous system. Yes, for you (probably not others), you can try three capsules a day. Report back what happens. We believe by the end of this year there will be major announcements that Longevinex is beneficial for the visual system. We are so pleased to hear of your experience. Your report will serve as an encouragement to others.
    – Bill Sardi, managing partner, LONGEVINEX

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