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How the world got lost on
the road to an anti-aging pill
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October 7, 2010: by Bill Sardi
Las Vegas, NV (October 7, 2010) – Longevinex® is the first resveratrol-based nutriceutical to demonstrate it abolishes the earliest sign of blood vessel aging and significantly inhibits a marker of inflammation, in humans.
In a 3-month study conducted among patients with metabolic syndrome (obesity, elevated blood sugar) in Japan, researchers report that 1-capsule of Longevinex® taken daily strongly inhibits loss of “flow mediated dilatation,” which is described as impaired ability of arteries to widen (dilate) with increased heart rate induced by physical exertion or stress. If the arteries do not dilate when a human goes from a resting heart rate to a faster heart rate, then the artery remains abnormally narrow, blood pressure rises abnormally, and the threat of a stroke becomes real.
In addition to flow-mediated dilatation, Longevinex® significantly lowered insulin, insulin resistance, adiponectin (a protein secreted by fat cells) and C-reactive protein (a marker of inflammation). Longevinex®, which provides a unique blend of resveratrol, quercetin, ferulic acid, rice bran IP6 from botanical sources as well as vitamin D3, was given to 15 patients and compared to conventional care. There were no statistically significant improvements noted in the patients receiving conventional doctor’s care.
Bill Sardi, spokesperson for Longevinex®, says this very encouraging news since it begins to answer the demand for human studies, as up to this point in time most of the resveratrol research has been done in lab dishes or the animal laboratory. This study also encouragingly points to markers linked with mortality which show resveratrol may one day live up to its billing as an anti-aging pill.
Results of the study will be presented at an upcoming meeting of the Japanese Circulation Society.
A chart providing the full results of the study is presented below. ### © 2010 Resveratrol Partners LLC
|Comparison of 1-Capsule/Day Longevinex® Vs. Conventional Care Among Human Subjects With Metabolic Syndrome Obesity, Elevated Blood Sugar)|
|Longevinex Group (15 subjects)||Conventional Care Group (15 subjects)|
|Measured Parameters – 3 month study||Before||After||P value||Before||After||P value|
|Body mass index (weight + height to indicate %body fat)||28.4||28.2||0.202 null||26.2||25.8||0.255 null|
|Waist circumference (in centimeters; 2.5 centimeters = 1 inch)||100||99||0.524 null||92.4||92.5||0.784 null|
|Body weight (in kilograms; 1 kilogram = 2.2 lbs)||77||76||0.266 null||68||67||0.254 null|
|Systolic blood pressure (thrusting pressure) (mmHg)||131||126||0.398 null||129||131||0.487 null|
|Diastolic blood pressure (resting pressure) (mmHg)||73||76||0.456 null||77||75||0.454 null|
|Triglycerides (mg/dl)||138||133||0.741 null||116||116||0.963 null|
|High-density lipoprotein (HDL “good” cholesterol) (mg/dl)||47||46||0.693 null||51||50||0.485 null|
|Low-deinsity lipoprotein (LDL “bad” cholesterol) (mg/dl)||100||99||0.700 null||112||106||0.207 null|
|Ferririn (iron storage protein; 20-50 is healthy range) (ng/ml)||128||127||0.881 null||128||121||0.372 null|
|Hemoglobin A1c (long-term blood sugar control) (%)||5.4||5.3||0.589 null||5.8||5.8||0.919 null|
|Fasting blood sugar (mg/dl)||106||107||0.882 null||105||112||0.087 null|
|Fasting serum insulin (µg/ml)||14.7||9.3||0.021*||13.7||16.7||0.289 null|
|Homeostasis model for insulin resistance||14.7||9.3||0.026*||13.7||16.4||0.289 null|
|Total adiponectin (protein secreted by fat cells) (µg/ml)||6.43||7.42||0.052*||7.31||6.63||0.186 null|
|High molecular weight adiponectin (µg/ml)||3.12||3.75||0.030*||0.356||0.332||0.453 null|
|Highly-sensitive C-reactive protein (inflammation) (mg/dl)||0.151||0.068||0.024*||0.175||0.105||0.246 null|
|Nitrate + nitrite (marker for nitric oxide) (µmol/L)||47.9||65.1||0.025*||44.7||45.4||0.740 null|
|Flow-mediated dilatation (widening of arteries upon exertion)||6.2%||9.0.%||0.007*||6.0%||6.5%||0.227 null|
P value = statistical significance (lower number is greater significance, example: 0.007 is better than 0.020; 0.050 and lower is better than chance);
Data and chart: ©2010 Resveratrol Partners LLC www.longevinex.com