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June 25, 2013: by Bill Sardi
Good News For Men- Resveratrol Restores Erectile Dysfunction In Diabetic Lab Rats.
The patents on Viagra just recently expired and prices are falling for generic Viagra, but a recent study suggests the red wine molecule resveratrol (rez-vair-ah-trol), taken at a dose of 5 milligrams per kilogram (2.2 lbs) of body weight (equivalent to ~350 mg for a 160-lb adult male), restores erectile function among diabetic animals. Lower doses probably work as well. Mega-dose resveratrol may be problematic.
Erectile dysfunction plagues males with elevated blood sugar levels. Erectile dysfunction is estimated to affect between 35% and 75% of diabetic males, which is three times higher than the incidence in non-diabetic men. ©2013 Bill Sardi, ResveratrolNews.com
Asian Journal Andrology. 2013 Jun 24. doi: 10.1038/aja.2013.60. [Epub ahead of print]
Department of Urology, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210008, China.
The high incidence of erectile dysfunction (ED) in diabetes highlights a need for effective treatment strategies. Resveratrol, an activator of silent information regulator 2-related enzymes 1 (sirtuin1, SIRT1), has received attention for its valuable effects in cancer, neurodegenerative diseases, longevity and cardiovascular disease. To explore the effects of resveratrol in diabetes-induced ED, resveratrol was administered to rats with streptozocin (65 mg kg-1)-induced diabetes. Erectile function, cavernous structure, tissue protein expression of silent information regulator 2-related enzymes 1 (sirtuin1, SIRT1), p53 and forkhead transcription factor O 3a (FOXO3a), superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels in the corpora cavernosa were studied. We found that SIRT1 was expressed in cavernosal tissue, and it was down-regulated in the corpora of diabetic rats. The administration of resveratrol upregulated the expression of SIRT1 and restored erectile function. In contrast, resveratrol down-regulated the expression of p53 and FOXO3a, which regulate apoptosis and oxidative stress. Furthermore, the resveratrol-treated group showed an improvement in smooth muscle content, SOD activity and MDA levels when compared with the diabetic group. Therefore, the ability of resveratrol to improve diabetes-induced ED is likely related to its activation of SIRT1 expression, thus causing the suppression of apoptosis and resistance towards oxidative stress. Asian Journal of Andrology advance online publication, 24 June 2013; doi:10.1038/aja.2013.60. PMID: 23792339