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How the world got lost on
the road to an anti-aging pill
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October 4, 2013: by Bill Sardi
After a decade of scientific doubt that resveratrol is biologically available in the human body following liver metabolism, cancer researchers in Great Britain demonstrate that not only does the red wine molecule resveratrol exert biological action but liver metabolism potentiates it.
Mistakenly believing resveratrol is not biologically available once it attaches to detoxification molecules (sulfate, glucuronate) as it passes through the liver, in 2010 mega-dose (5000 mg) resveratrol was employed in a human study of bone marrow (multiple myeloma) patients which resulted in immediate kidney failure that put a halt to the trial.
Also a human clinical trial has been launched employing mega-dose resveratrol among Alzheimer’s subjects, with dosing being established by the assumption resveratrol is not bioavailable.
The participation of pharmaceutical researchers in spreading this falsehood remains hidden. If you go to the link for a report on the bioavailability of resveratrol you must click on “author affiliations” to find out a researcher affiliated with a major pharmaceutical company was involved in the study.
This writer believes the pharmaceutical industry has used the false notion that resveratrol is not bioavailable to slow down scientific progress as resveratrol represents a threat to Big Pharma as it has been said it could replace over 20 different classes of drugs.
Researchers now report that attachment of resveratrol to sulfate stabilizes the molecule, prolongs its half-life and delivers resveratrol to target tissues. It only took a decade for researchers to prove this, despite prior studies already showing resveratrol-sulfate has comparable or greater potency than resveratrol alone.
Some resveratrol is also metabolized in the digestive tract where it has now been shown to resveratrol was detected in the mucus lining of the digestive tract for as long as 24 hours.
Prior to this experiment researchers believed once resveratrol is attached to a carrier protein such as sulfate that it would be too large a molecule to pass through cell walls. But surprisingly resveratrol-sulfate did cross cell membranes rapidly. ©2013 Bill Sardi, ResveratrolNews.com