Comprehensive Library Of Resveratrol News

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Jennifer Aniston, arguably judged the most attractive female on the planet at the moment, has risen to this “most admirable” spot at age 43.  Menshealth.com goes a step further, anointing Aniston as the hottest woman of all time.

According to an article in the Sydney Morning Herald, Aniston says she maintains her shape and beauty by daily exercise, pumping small hand weights in hotel rooms, and taking dietary supplements such as fish oil and resveratrol (rez-vair-ah-troll), the red wine molecule.  No wonder she gets admired by a male health mag, her pill regimen beats that of most celebs who have been known to pop stimulants of all kinds.  No, Aniston is not likely to enter rehab anytime soon to go through withdrawal from resveratrol pills.  Is the fairer sex missing some beauty secret here?  Maybe.

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Lifts Cloud Of Uncertainty From This Super Molecule, But Researchers Want To Supplant It With A Drug

Over eight years after a Harvard University researcher mistakenly identified the primary gene target of resveratrol (rez-vair-ah-troll) as a survival gene (Sirtuin1) that is also variably activated by calorie restricted diets, National Institutes of Health (NIH) researchers say they have now identified an enzyme (phosphodiesterase4 or PDE4) as the first gene target of resveratrol. Specifically, this enzyme is inhibited by resveratrol, known as a red wine molecule. All of the antioxidant molecules in red wine are enzyme inhibitors.

The Sirtuin1 gene is not totally out of the picture, it is activated indirectly in the gene pathway along with other important metabolic gene targets such as NAD, PGC1a and AMPK. The study, which was conducted in mice, needs to be replicated in humans.

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Vacillating Consumers Missing Greatest Gift Of Natural Medicine To Mankind; Cardiology Drags Its Feet While Millions Needlessly Succumb To Mortal Heart Attacks

Unless you are a died-in-the-wool resveratrol pill user, you are likely having doubts over whether you should continue taking these so-called red wine pills now that the science published by a leading researcher in the field has been called into question (more about that below). Strangely enough, the science behind resveratrol’s miraculous ability to protect the human heart is very well founded, but when did solid science ever influence consumers anyway?

The record shows consumers of resveratrol pills are more likely to fall for a phony sales pitch rather than phony science. Except for a brief period in 2009 when online spammers falsely claimed their products were endorsed by Oprah Winfrey, pandered resveratrol pills as a cure-all for whatever ails mankind, made free bottle offers that came with fine print and unwanted monthly $85 credit card billings for more resveratrol pills and sold millions of bottles of these pills, consumers of dietary supplements have not widely adopted resveratrol pills into their daily pill regimens and appear to be paying a steep price for it with their lives.

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It’s Not Sirtuin1, it’s cAMP-dependent phosphodiesterases

While researchers have argued over whether Sirtuin1 is the direct or indirectly-activated gene responsible for its molecular mimicry of calorie restriction, researchers now claim resveratrol works directly by inhibiting enzymes called cAMP-dependent phosphodiesterases which then triggers a cascade of events that includes Sirtuin1. You also see the name of a pharmaceutical company in Japan participating here. (see attached paper)

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