Comprehensive Library Of Resveratrol News

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  • A Tale Of Two Sirtuins

    June 30, 2011: by Bill Sardi

    Has The Holy Grail Of Anti-Aging Been (Re-)Discovered?

    KEY POINTS

    • Thepromise of the Sirtuin1 gene as anti-aging target has been disappointing.
    • Long-living humans found to have active Sirtuin3 gene.
    • Sirtuin1 gene located in cell cytoplasm whereas Sirtuin3 controls antioxidant protection (SOD*) inside mitochondria where cell energy and 90% destructive oxygen free radicals are produced.
    • Feverishly-paced research is underway to confirm Sirtuin3 as true anti-aging pill.
    • Resveratrol molecule stimulates Sirtuin3 gene; Longevinex® resveratrol matrix activates Sirtuin3 2.95-fold greater than plain resveratrol.

    * SOD = superoxide dismutase

    Genes they be — a Sirtuin family of seven “silent information regulators” that are guardians of the cell. Sirtuins have been linked with prolonged lifespan in various life forms, starting with yeast cells, fruit flies and roundworms.1

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  • Sirtuin1 Gene Target Called Into Question Again. Resveratrol Has Anti-Cancer Properties Independent Of Sirtuin1 Gene

    June 2, 2011: by Bill Sardi

    Researchers at the Ottawa Research Institute report that resveratrol still exerts anti-cancer action, sometimes in profound ways, but that the Sirtuin1 gene is not always required to produce such an effect. Mice bred without a functioning Sirtuin1 gene did not develop fewer intestinal polyps (see graphic below).

    The assumption is that Sirtuin1 is a survival gene that is switch on in calorie restricted animals who have double the lifespan of animal fed a normal diet. Resveratrol is a molecule that is purported to activate the Sirtuin1 gene. But subsequent studies don’t always validate the idea that the Sirtuin1 gene is a strong anti-cancer gene. In fact, Sirtuin1 gene proteins are produced at a high level in lymph gland tumors (B-cell lymphomas) and are accompanied by a poor prognosis in B-cell lymphomaand breast cancer.

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