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How the world got lost on
the road to an anti-aging pill
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June 17, 2010: by Bill Sardi
It has been a long time coming — since 2003 when Konrad Howitz PhD of Biomol and Dr. David Sinclair of Harvard Medical School first reported in Nature Magazine that yeast cells lived longer when given resveratrol, a red wine molecule — for human studies to ensue.
Publication of the first small studies involving resveratrol pills in humans appear to be encouraging, but obviously lack conclusiveness. It will take a few decades to convincingly prove a pill can reliably extend human life.
One of the markers of aging is inflammation. In fact, aging has been called “inflammaging.” Researchers at the State University of New York found that 40 milligrams of resveratrol taken daily by young adults for six weeks significantly reduces markers of inflammation (tumor necrosis factor-TNF, C-reactive protein – CRP) as well as measures of oxidation. An abstract of the study can be viewed online here.
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June 11, 2010: by Bill Sardi
Researchers in France have completed the first year of a 5-year study of 38-month old grey mouse lemurs, naturally found on the Island of Madagacar. These lemurs live generally 8-10 years and 5 years of study will likely provide sufficient data on longevity effects of a calorie restricted diet or its proposed molecular mimic, resveratrol.
The dose of resveratrol used in this study is beyond practicality in humans – 200 milligrams per kilogram (2.2-lbs) of body weight per day, or the human equivalent of 14,000 milligrams per day for a 70-kilogram (160-lb) human.
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: by Bill Sardi
Say again? Pterostilbene? (pronounced “tero-STILL-bean”) If you take resveratrol pills you probably have never heard of pterostilbene, but it is a naturally-occurring, molecular look-alike of resveratrol.
Pterostilbene is alleged to be superior to resveratrol and the commercial availability of a pure form of pterostilbene (pTeroPure) is creating some manufacturer-driven hype that consumers should opt for it over resveratrol.
The actual development of pterostilbene as a raw material for dietary supplements began with research conducted by US Department of Agriculture scientists. Pterostilbene is derived from blueberries. It’s being imported from India as a nearly pure extract.
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