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How the world got lost on
the road to an anti-aging pill
August 29, 2009: by ResveratrolNews
Journal Comparative Physiology B (2008) 178:439–445
It may be difficult for humans to fathom that there is a African rodent that doesn’t age, is rarely ill, doesn’t get cancer, diabetes, or experience bone loss with advancing age, and whose females continuously produce babies and don’t experience a “change of life.” This tunneling rat outlives other rodents by ten fold. Your average pet lab rat lives ~3 years, this rodent 28-30 years!
Welcome to the world of the naked mole rat. Naked refers to its hairless pink skin.
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August 7, 2009: by ResveratrolNews
The Chicago Tribune report of a terminal cancer patient’s successful prolonged survival, credited to her use of a drug that inhibits the mTOR-gene pathway combined with “fresh-preserved” grapefruit juice, should have striking impact upon longevity seekers.
The reason? — The drug used to inhibit the mTOR gene pathway is rapamycin, recently heralded in the news media because it was found to significantly prolong (by 14%) the life of lab animals even though it was employed at a latter stage of their lifespan. [Nature. 2009 Jul 16;460(7253):392-5]
Rapamycin levels are so enhanced by grapefruit juice that once-weekly dosage produced drug concentrations equal to every-day dosing without juice.
Molecules in grapefruit juice are known to enhance the effects of drugs by inhibiting detoxification enzymes in the liver.
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August 4, 2009: by ResveratrolNews
Frank Weinberg and Navdeep S. Chandel, researchers at Northwestern University Medical School in Chicago, provide a profound new understanding of the role of reactive oxygen species in cases of cancer.
They report that tumor cells in lab dishes impair the production of p38, an inflammatory protein, and p53, an anti-cancer gene protein, to evade apoptosis (cell death) and for tumor generation to proceed.
In the diagram provided below these researchers distinguish reactive oxygen species (free radical generation) in normal cells vs tumor cells. In normal cells, low levels of oxygen free radicals can regulate controlled proliferation and growth via cell signaling whereas with high levels of free radicals induce cell death and senescence. Cancer cells with mutations in tumor suppressor genes (p53) can evade free radical generated cell death. Cancer cells exhibit high levels of free radicals leading to uncontrolled cellular proliferation (growth by rapid multiplication).
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August 2, 2009: by Bill Sardi
Researchers in France have conducted a striking experiment in animals to measure the chronobiological effects of resveratrol (rez-vair-ah-trawl), known as an antioxidant derived from red wine.
Chronobiology is a field of science that examines periodic (cyclic) phenomena in living organisms and their adaptation to solar and lunar related rhythms. http://en.wikipedia.org/wiki/Chronobiology
Male rodents were administered resveratrol at three different dosages, equivalent to 56 mg, 140 mg and 350 mg, during light (day) and dark (night) periods and measurements of oxidation (TBARS- thiobarbituric acid reactive species) were conducted in heart, liver and kidney tissues.
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