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How the world got lost on
the road to an anti-aging pill
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January 1, 2022: by Bill Sardi
Researchers report prolonged exercise in laboratory animals improves learning and brain function via growth hormone that stimulates new brain cells (neurons) in the memory center (hippocampus) region of the brain. This suggests older adults remain physically active to delay or entirely head off dementia, a leading cause of death.
A reduced number of stem cells needed to renew the brain are a characteristic of the aging brain.
The study was conducted in 24-month old laboratory mice.
Prior studies reveal older mice whose circulatory system is paired with younger mice (something call parabiosis) experienced reduced brain aging. Even injections of blood plasma from young mice to old improves memory and learning.
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July 26, 2013: by Bill Sardi
Researchers at the University of Copenhagen say they take my allegations of maligned science very seriously. They weakly defend their preposterous claim that resveratrol produces a significant reversal of the effects of physical exercise. Here is my response to their email:
To: Mr. Gliemann (student, PhD candidate):
Maybe you have learned to fool yourself with your own numbers.
At no time did resveratrol meaningfully (but maybe, just barely, statistically) negate the effects of exercise.
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July 22, 2013: by Bill Sardi
Las Vegas, NV (July 22, 2013) – Well, the above headline is not the one you are reading in today’s news.
What you are reading is:
“Red wine blunts benefits of exercise in men” –The Indian Express
“Too Many Antioxidants? Resveratrol blocks many cardiovascular benefits of exercise” –Science Daily
“Glass of red could undo the effects of exercising” (Express UK)
“La ‘píldora de la eterna juventud’ es cuestionada (the pill of eternal youth is questioned) (La Nacion Costa Rica)
A bevy of prior studies conducted in mice came to contrary conclusions. Mice on treadmills improved their endurance and stamina and many measurable parameters of health improved as well. But moving from mice to men is another thing. So why the disparity between studies with laboratory mice under controlled dietary and environmental conditions and senior (human) males in a placebo-compared trial?
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June 19, 2012: by ResveratrolNews
June 19th, 2012 in Health
A natural compound found in some fruits, nuts and red wine may enhance exercise training and performance, demonstrates newly published medical research from the University of Alberta.
Principal investigator Jason Dyck and his team found out in experiments that high doses of the natural compound resveratrol improved physical performance, heart function and muscle strength in lab models.
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January 5, 2022: by Bill Sardi
Choosing to live super-long doesn’t sound plausible. Many people believe longevity is governed by their forefathers who passed on good genes. But every human has the same set of genes.
For the most part, genes aren’t fixed. Only ~2% of disease is inherited. Genes respond and adapt to the environment, temperature, radiation, food supply, by making proteins, what is called gene expression; or by not making proteins, which is called gene silencing. So how do we influence our genes so we can live indefinitely long? The answer to that question is presented below.
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November 24, 2021: by Bill Sardi
This Christmas the most desired gift may be a resveratrol pill as an antidote to a predicted smallpox pandemic. Resveratrol (rez-vair-ah-troll) being that molecule in red wine that prevents blood-clotting heart attacks and activates the Sirtuin1 survival gene that mimics a lifespan-doubling calorie-restricted diet.
This is because, like the Director of the National Institute of Infectious Diseases 2017 prediction that a looming pandemic would soon materialize unless his institute was adequately funded, we now have a billionaire vaccine backer masquerading as a philanthropist, who just happens to have ownership in a company that recently gained FDA drug approval for smallpox, and just happens to have spent $319 million bankrolling the news media, asking news reporters what are we going to do if and when biological terrorists release smallpox in ten airports?
This has resulted in news chatter blamed on conspiracy theorists that Bill Gates will unleash smallpox on Christmas day.
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April 12, 2021: by Bill Sardi
It’s April 7, 2021 and Newsweek magazine posted up a review article about the state of anti-aging pills. Any avid longevity seeker who has been following this story over time would have thought it was written over a decade ago. The promise of an anti-aging pill is getting old.
An anti-aging pill is always another decade away, another long-term controlled human trial, a conclusive meta-analysis providing compelling data to build a consensus of experts. But then again, that will never be enough.
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December 7, 2019: by Bill Sardi
Modern medicine is at it again, attempting to develop an expensive synthetic molecule that will reap billions of dollars of sales when there is a more economical natural molecule that may even work in a superior fashion to a heralded new drug.
Here’s the new option now that researchers believe a recent breakthrough can avert age-related mental decline: (1) wait ten years for completed trials of a synthetic drug that abolishes memory loss which commonly occurs with advancing age; or (2) take resveratrol pills that work by a similar if not stronger mechanism than the aforementioned drug.
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August 5, 2019: by Bill Sardi
Longevity seekers have heard all this before, but we hear more today:
“Anti-Ageing drugs are coming” – New Scientist April 2019; Medical Xpress Sept. 2018
“Longevity and anti-aging research: prime time for an impact on the globe” – Harvard Gazette March 2019
“Healthy To 100?” — San Diego Union Tribune July 2019
You may be alive when the first anti-aging pill is granted approval by health authorities. Or hve one or two already materialized but just dismissed by those who seek to control the anti-aging marketplace? Or will public health authorities ever let an anti-aging pill gain traction?
Anti-aging investigator Josh Mitteldorf says “it may soon be possible to measure changes in the rate of human aging over periods as short as a year or two” instead of the impractical challenge of a lifetime study in humans to produce conclusive evidence.
Don’t hold your breath for the first human trial of an purported anti-aging pill (anti-diabetic drug metformin/Glucophage) is about to begin, and will take 5-7 years to complete. But metformin only increased lifespan in lab animals by 4-6%.
Is the public being set up for disappointment that will dash or delay the approval of more promising anti-aging agents? And given that metformin may induce vitamin deficiencies and other side effects such as chronic diarrhea, I wouldn’t be surprised if the study were sponsored by the makers of Depend® adult diapers.
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July 18, 2019: by Bill Sardi
Oh, that’s just a headline to gain your attention. However, it is based upon recently published science (Frontiers in Physiology July 18, 2019) showing the red wine molecule RESVERATROL “mitigated” partial (0.38 g) gravity conditions as found on the planet Mars in laboratory animals.
Resveratrol was shown to preserve muscle function and mitigate muscle atrophy (shrinkage) in partial gravity conditions among laboratory mice. Scientifically resveratrol is already known as a physical exercise mimetic.
While there are zero space travelers to Mars at the present time, this research has application to humans living into their eighth and ninth decades who experience bone and muscle loss, a condition called sarcopenia.
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